Information for patients • Take Eliquis® regularly as instructed. If you miss a dose, take it as soon as you remember and continue to follow your dosing schedule. • Do not stop taking Eliquis® without talking to your doctor, as you are at risk of suffering from a stroke or other complications. • Eliquis® helps to thin your blood. However, this may increase your risk of bleeding. • Signs and symptoms of bleeding include bruising or bleeding under the skin, tar-coloured stools, blood in urine, nose-bleed, dizziness, tiredness, paleness or weakness, sudden severe headache, coughing up blood or vomiting blood. • If the bleeding does not stop on its own, seek medical attention immediately. • If you need surgery, inform your doctor that you are taking Eliquis® . DATE OF PREPARATION: April 2016 432UK1600804-01 I am under anticoagulation treatment with Eliquis® (apixaban) to prevent blood clots Information for healthcare professionals • Eliquis® (apixaban) is an oral anticoagulant acting by direct selective inhibition of factor Xa. • Eliquis® may increase the risk of bleeding. In case of major bleeding events, it should be stopped immediately. • Treatment with Eliquis® does not require routine monitoring of exposure. A calibrated quantitative anti-Factor Xa assay may be useful in exceptional situations, e.g., overdose and emergency surgery (prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (aPTT) clotting tests are not recommended) – see SmPC.