Medicinal Chemistry: Definition and history. Drug nomenclature. Seminar: Organisation of seminars. Syntheses and metabolism of selected strong and weak analgesics and non- steroidal anti-inflammatory drugs (NSAIDs).

Physico-chemical descriptors and biological activity. Structure-Activity Relationships. Structure optimization. An introduction into Quantitative Structure-Activity Relationships (QSAR). Seminar: Syntheses and metabolism of analgesics (continued). Sytheses and metabolism of selected local and general anesthetics.

Drugs research and development. Drug patents. Approvals of drug preparations. Good laboratory, manufacturing and clinical practices (GLP, GMP, GCP). Seminar: Syntheses of platinum anticancer drugs. (Mgr. Kroutil)

Structural features influencing drug action. Seminar: Syntheses and metabolism of selected antipsychotics.

Adrenergic receptor agonists directly and indirectly acting. Appetite suppressants and other antiobesics. Seminar: Synthesis and metabolism of selected adrenergics

Adrenergic receptor antagonists. Seminar: Synthesis and metabolism of selected adrenergic receptor antagonists

Drug biotransformation. Seminar: Metabolism and syntheses of antipychotics continued.

(April 27th) Prodrugs. Weak analgesics - part 1. Seminar: Synthesis and metabolism of selected antidepressants, anticonvulsants and antiepileptics.

(May 4th) Weak analgesics - part 2. Strong analgesics. Seminar: Metabolism and syntheses of antibacterial chemotherapeutics - part 1.

(May 11th) General and local anethetics, muscle relaxants. Seminar: Metabolism of antibacterial compounds 2

(May 18th) Antidepressants. CNS stimulants, cognitive enhancers, halucinogens. Seminar: Metabolism of selected antimycotics.

(May 25th) CNS drugs II.: Antipsychotics, anxiolytics, hypnotics, sedatives. Seminar: final credit test.