Introduction to the discipline. History of medicinal chemistry, nomenclature of drugs.

Physico-chemical descriptors and biological activity. Structure- Activity-Relationships. Structure optimization. An introduction to Quantitative Structure-Activity Relationships (QSAR).

Structure modification

General aspects of drug metabolism.

Prodrugs. Structure features that influence drug activity.

Adrenergic receptor agonists

Strong or opioid analgesics. Endogenous opioids. Opioid receptors antagonists.

Adrenergic receptor antagonists

Research and development, Legislational requirements, GMP

General and local anesthetics. Muscle relaxants.

Antipsychotics. Anxiolytics.

CNS agents: antidepressants, stimulants, cognitive enhancers, psychotomimetics – hallucinogens.

CNS agents: sedatives, hypnotics. Anticonvulsants, antiepileptics. Emetics, antivomitics, antikinetics.