SYLLABUS PATHOBIOCHEMISTRY 2024_Lectures

1. Introduction, the importance of studying pathobiochemistry. The scope and requirements for successfully completing the course exam and recommended literature. Metabolism disorders, types and causes. Hereditary metabolic diseases.

2. Treatment. Enzymes, regulation of metabolism. Causes of cellular enzymes increased activity in the plasma. Clinically significant enzymes.

3. Amino acid metabolism and its disorders. Types of diseases and therapy.

4. The nucleic acid metabolism disorders of purine and pyrimidine. Hyperuricemia, orotacidurie, therapy.

5. Pathobiochemistry of carbohydrates, glucose metabolism, and its disorders. Glycemic control disorders. Pathobiochemistry of diabetes mellitus, types of DM. Disorders of glycogen metabolism, glycogenosis.

6. Disorders of lipid metabolism. Cholesterol, lipoproteins. Lipidoses, dyslipoproteinaemia.

7. Principles of metabolism regulations. Receptors. Biochemical communication..

8. Pathobiochemistry of inflammation.

9. Blood, blood plasma proteins. Blood clotting, coagulopathy. Dysproteinaemias. Porphyrins. Biosynthesis, metabolism disorders. Porphyria, hemoglobinopathies.

10. Tumor, tumor markers. Basic characteristics of tumor cells. Strategy laboratory tests. Requirements of ideal tumor marker. Tumor markers in common use..

11. Pathobiochemistry of arteriosclerosis. Ischemic heart failure - cardiac markers.

12. Xenobiotics and their effects on the body. Detoxification mechanism. Biological oxidation. The effects of free radicals on the organism. Lipoperoxidation antioxidants

Summary