1. Introduction, the importance of studying pathobiochemistry. The scope and requirements for successfully completing the course exam and recommended literature. Metabolism disorders, types and causes. Hereditary metabolic diseases. (Thu 20/02) 

2. Treatment of inherited metabolic disorders. Enzymes, regulation of metabolism. Causes of cellular enzymes increased activity in the plasma. Clinically significant enzymes. (27/02) 

3. Amino acid metabolism and its disorders. Types of diseases and therapy. (06/03) 

4. The nucleic acid metabolism disorders of purine and pyrimidine. Hyperuricemia, orotacidurie, therapy.(13/03) 

5. Pathobiochemistry of carbohydrates, glucose metabolism, and its disorders. Glycemic control disorders. Pathobiochemistry of diabetes mellitus, types of DM. Disorders of glycogen metabolism, glycogenosis  (20/03) 

6. Disorders of lipid metabolism. Cholesterol, lipoproteins. Lipidoses, dyslipoproteinaemia. (27/03) 

7. Blood, blood plasma proteins. Blood clotting, coagulopathy. Dysproteinaemias. Porphyrins. Biosynthesis, metabolism disorders. Porphyria, hemoglobinopathies.  Dr.Treml (03/04) 

8. Principles of metabolism regulations. Receptors. Biochemical communication.  (10/04) 

9. Tumor, tumor markers. Basic characteristics of tumor cells. Strategy laboratory tests. Requirements of ideal tumor marker. Tumor markers in common use. (17/04)

10. Pathobiochemistry of arteriosclerosis. Ischemic heart failure - cardiac markers. (24/04) Mgr.Nykodýmová 

01/05/25 - National holiday

08/05/25 - National holiday

11. Pathobiochemistry of inflammation. (15/05) Dr.Kos

12.  Xenobiotics and their effects on the body. Detoxification mechanism. Biological oxidation. The effects of free radicals on the organism. Lipoperoxidation antioxidants. (09/05) 

! The last lecture - 13. Urinalysis and analysis of the urinary sediment - will be uploaded as a chapter in the Interactive Syllabus for self-study. (Mgr.Nykodýmová)