DERMATOLOGY
PharmDr. Marek Lžičař
FAFP1 Pharmaceutical care I
Lecture, 5. 11. 2018
Information about skin
 The biggest part of human body
 Body surface 1,6 – 2 m2
 Weight 3 kg, with fatty tissue more then 20 kg
 Skin contents cca 70 % of water
 Epidermis (cuticle) – stratum corneum
 Dermis – elastic, collagen fibers, mast cells,
vascular and nerve fibers
Skin functions
Protective
Barrier
• acid pH, Langerhans cells as a part of immune system
Thermoregulatory
• vasoconstriction and vasodilatation, sweat formation – cooling
Sensory
• receptors for press, touch, nociceptors, thermoreceptors
Resorption and excretion
• Sebaceous glands
Vitamin D production
• After sunlight
Dermatological drugs
 Medicines for the treatment of skin disease
 Local treatment
 Systemic treatment
 The effect of the therapy depends on the
pharmaceutical form, lipophilic properties,
molecular size and concetration of active
substance
 The medicine absorption is affected by age, sex,
skin hydratation, application site
Dermatology medicines
Emollients and protectives
Antiseptics and disinfectants
Antifungals
Antivirotics
Antipsoriatics
Anti-acne preparations
Antiphlogistics
Antiectoparasitics
Emollients
Soften, smoothen, skin hydratation
 Urea
 Lactic acid
 Ointment base
Bath oils (Balneum hermal, Balmandol oil, Linola-Fett-
Olbad)
Emulsions, creams (Excipial U, Linola, Lipobase)
How to use it?
Antimycotics
 Infections caused by pathogenic funghi and
yeast
 The most frequent pathogens
 Candida
 Pityrosporum
 Microsporum
 Trichophyton
 Affected areas: nails, (onychomycosis), hair, feet,
vaginal mucosis
 Frequent complication of diabetes mellitus
Antivirotics
Herpes simplex skin infections
HPV infections
Warts
Antipsoriatics
 Psoriasis vulgaris
quite common disease (2 – 3 % populace
- Autoimmune disease
 It causes cells to build up rapidly on the surface
of the skin.
 The extra skin cells form scales and red patches
that are itchy and sometimes
 Type I
 Type II
Acne
 Skin condition that occurs when hair follicles
become plugged with oil and dead skin cells
 Usually appears on face, neck, chest, back and
shoulders
 Most common among teenagers
Eczema - Atopic dermatitis
 Inflammatory skin disease
 long lasting (chronic) and tends to flare
periodically.
 It may be accompanied by asthma or hay
fever
Scabies
 an itchy skin condition caused by a tiny burrowing
mite called Sarcoptes scabiei
 The presence of the mite leads to intense itching in
the area of its burrows
 The urge to scratch may be especially strong at
night.
Head lice
 Tiny insects that feed on blood from the human
scalp
 most often affects children
 direct transfer of lice from the hair of one person
to the hair of another
Conclusions
Treatment of skin diseases must be
complex
Individual therapy is needed
Causal therapy is often unknown