PhD Position Available in the Laboratory of Cancer Biology   :YfY
Department of Biology, Faculty of Medicine, Masaryk University Brno, to study:
Mechanisms regulating the function of oncoproteins MDM2
and MDMX in cancer cells
MDM2 and MDMX are important cellular regulators of the tumour suppressor p53 that are
often over-expressed in cancer cells. We have shown recently that MDM2 and MDMX can
directly cooperate in the regulation of p53 stability and we have also identified a novel
functional domain required for their direct physical interaction (Uldrijan etal. 2007, EMBO J
26(1):102-120)
The successful candidate for the PhD studentship will study:
• MDM2-MDMX interactions and their regulation
• The role of the acidic and RING domains of MDM2 and MDMX using site-directed mutagenesis
• The function of newly identified protein binding partners for MDM2
The ideal candidate will be a highly motivated student interested in cancer biology with experience in
cell culture and/or molecular biology techniques.
For more information or to apply please contact:      Mgr. Stjepan Uldrijan, CSc.
Department of Biology Faculty of Medicine, Masaryk University Kamenice 5 / A6, 62500 Brno E-mail: uldrijan@med.muni.cz Tel : 549494040