Inhibition of Stat3 activation in the endometrium
                          prevents implantation: A nonsteroidal approach
                                         to contraception

Rob D. Catalano*†, Martin H. Johnson‡, Elizabeth A. Campbell‡, D. Stephen Charnock-Jones§, Stephen
                                            K. Smith§,

                                      and Andrew M. Sharkey*



*Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge
                              CB2 1QP, United Kingdom; ‡Department of

Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom; and §Department of Obstetrics
                             and Gynaecology, University of Cambridge,

                                 Cambridge CB2 2SW, United Kingdom



                                        Implantace (nidace)

                                       Implantace – faktory

•             Blastocysta, 4 dpc          interakce trofoblastu a sliznice (luminal epithelium, LE)



•             Přestavba endometria – decidualizace, sekreční fáze     receptivita



•             Pod vlivem estrogenu a progesteronu z ovarií





                                  Signální dráha gp130 – JAK/STAT

                                              Summary









                                           Kmenové buňky

            Effect of intrauterine injection of STAT 3 inhibitor on implantation rates

Stat3 phosphorylation status and response to LIF in LE isolated on day 3 (noon) or day 4 (noon) of
                                             pregnancy

            Effect of Stat3 inhibitor on the expression of LIF-regulated genes in vitro

In vivo administration of Stat3 inhibitor reduces phosphorylation of Stat3 in the LE in response to
                                                LIF

            Effect of Stat3 inhibitor on the expression of LIF-regulated genes in vivo

In vivo administration of Stat3 inhibitor reduces phosphorylation of Stat3 in the LE in response to
                                                LIF