Not practical
TABLE 8.2    GUIDELINES FOR DETERMINING THE REGIOCHEMICAL AND STEREOCHEMICAL OUTCOME OF SUBSTITUTION AND ELIMINATION REACTIONS
REGIOCHEMICAL OUTCOME
STEREOCHEMICAL OUTCOME
The nucleophile attacks the a posi- The nucleophile replaces the leaving tion, where the leaving group is group with inversion of configuration,
connected.
SN1
The nucleophile attacks the carbo-cation, which is where the leaving group was originally connected, unless a carbocation rearrangement takes place.
The nucleophile replaces the leaving group with racemization.
The Zaitsev product is generally favored over the Hofmann product, unless a sterically hindered base is used, in which case the Hofmann product will be favored.
This process is both stereoselective and stereospecific
When applicable, a trans disubstituted alkene will be favored over a cis disubstituted alkene.
When the (3 position of the substrate has only one proton, the stereoisomers alkene resulting from ant/-periplanar elimination will be obtained (exclusively, in most cases).
E1
The Zaitsev product is always favored over the Hofmann product.
The process is stereoselective. When applicable, a trans disubstituted alkene will be favored over a cis disubstituted alkene.