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AERO_Desky-3 [USEMAP]
BVT Presentation
 2012
BVT Technologies
RNDr. Jan KREJČÍ, PhD., Chief of executive board

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AERO_Desky-3 [USEMAP]
Introduction
ØBVT Technologies is small inovation company which  concentrates on research, development and
production of electrochemical sensors.
ØBVT Technologies was the first company which applied the microelectronic technologies to
electrochemistry.
ØBVT Technologies concentrates on the knowledge development, protection and use.

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Introduction
http://www.my-prague-sights.com/image-files/map-of-czech-republic-europe.jpg
Location – Czech Republic
BVT Technologies
Company headoffice:
BVT Technologies, a.s.
Hudcova 78c
Brno 612 00
www.bvt.cz
info@bvt.cz
Company branch office:
BVT Technologies, a.s.
Strážek 206
Strážek 592 53
www.bvt.cz
info@bvt.cz

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Introduction
BVT Technologies a.s.
Info@bvt.cz
TFT
Thick Film Technology
MAB
Medical application of biosensors
Scheme Structure
BVT Technologies
TAB
Trace analysis by biosensor
PPM
Projects and Personal management
FMP
Fine mechanical production
AC10 FC4 PME011

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Introduction


2012
BVT Technologies
ØEstablished in 2000
ØSME, up to 10 employees + external       workers
ØEquipped to produce screen printed electrochemical sensors and biosensors and accessories
ØStaff with more than 20 years expertise in R&D of electrochemical sensors and biosensors
ØClose co-operation with R&D centres (universities and research institutions on international
basis)
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Characteristic of the company

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Customers & Partners
Key Facts
http://www.edaq.com/images/menu/logo.gif Logo Go to PalmSens.com
http://www.qrins.com/tt/site/images/upload/qrinsfn.jpg Ezus - Serveur 24
http://www.ksi-meinsberg.de/images/dummy.gif http://www.ksi-meinsberg.de/images/dummy.gif
http://www.ga.com/images/h-header.png Teesside University. Link to home page. Probe Scientific TNO
innovation for life logo Z-Tech http://www.isibrno.cz/img/logooen.jpg Abnova Logo Logo IQ BVT
Technologies Home

MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSORS
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Key Facts
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BVT Technologies
 What are we doing ?

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AERO_Desky-3
  Program
Production of sensor by special technologies is the key know how of BVT. It is being developed and
protected systematically.
The key areas:
Ødesign and manufacturing of miniaturised thick film technology prepared  electrochemical sensors
and biosensors
Ønew technology enabling the integration of new materials as active surface including nanomaterials
Øintegration of electronics and other sensors in the sensor body

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Program
BVT Technologies
Accessories
The customer needs accessories to use the sensors effectively
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR

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Program
BVT Technologies
Ø   Connectors
Ø
Ø   Classical electrodes
Ø
Ø   Catheters
Ø
Ø   Stirrers
Ø
Ø   Pumps
Ø
Ø   Electrochemical cells
Accessories
OE2

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§
Program
BVT Technologies
Mass transport to sensitive surface of sensor
The reliable use of electrochemical sensor depends on transport of analyte from bulk of solution to
active surface. BVT offers its customer expertise in this field which enables to solve complicated
analytical problems.
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR

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§
Program
BVT Technologies
Examples of mass transport improvement
칬Ĭ
Mini Rotating disc electrode (mini RDE) is one exceptional example where the hydrodynamics (Navier
Stokes equations) and convective mass transport can be solved in analytical approximation.

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§
Program
BVT Technologies
Experimental arrangement
The use of thermodiffusion for mass transport enhancement.
Active part of sensor
Heating and thermistor on the back side of sensor

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Development of structured electrodes is made in wide international collaboration
Surface structure of platinum electrodes observed by confocal optical and electron microscopy
Improved mass transport, nanostructures
8111-ac1-1-e
Structures made by University of Southampton
Program

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Microfluidics
The connection of sensor and microfluidics offers another solution of the improvement of mass
transport between sensor and bulk of solution. Microfluidics however also offers the connection of
sensing techniques with separation techniques, filtration, mixing solutions and other sample
treatment. It enables the connection of sensor with HPLC, CE and other analytical methods.
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR
Program

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Microfluidics
Microfluidic devices made by classical technologies
The 3D TFT technology enables to produce the microfluidic structures by printing. The technology is
protected by Czech patent CZ297082.
Filtrrez chemie3
Example of microdialysis unit made by 3D TFT technology
The microfluidic chip is made by printing layer by layer.
FC2 106-0691_IMG
Microfluidic cell for sensors AC1
Capillary isotachophoresis modules made by Low temperature Cofired Ceramics
IMG_7295
Microfluidic cell for sensors AC1 with hydraulic connectors
Program

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Microdialysis
BVT collaborates with Probe Scientific (UK) www.probescientific.com. BVT connects its sensors to
microdialysis catheter. The technology enables continuous measurement of biochemical compound in
the living bodies. The analyte ( glucose for example) penetrate in the perfusate while the proteins
which can interfere with sensor reading do not penetrate. The system is robust in comparison with
other types of sensors.
MicroEye_RaumedicPic_081126_40x40 MicroEye Bloodstream
Program

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Microdialysis catheter with Biosensor
Prototypes of microdialysing catheters with biosensor and electronic are demonstrated. The
preliminary results of patient glucose measurement made in collaboration with Medical University of
Graz and Joanneum Research Graz in EU project EUCLAMP are shown.
01_komplet 100_3502
Program

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IPR Management
BVT is a small innovation company.  The innovation development is connected with Intellectual
Property management, licensing, participation in the public and commercial projects and employee
training.
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employee training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR
Program

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IPR management
US Patent: US  7,811,431B2
Ø The technology enables the preparation of surfaces with defined purity and defined structure.
Ø
Ø Sensors can be used either for measurement or as a basis for creating nanostructures on the
active surface.
Patent applications PV 2008-48
Ø The use of thermodiffuison for mass transport improvement at sensors
Patent applications PV 2009-22
Ø The sensors with integrated reaction vessel
Program

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Research and development
•DLC - TIP programme of Ministry of Industry and Trade of the Czech Republic
•CDV – The second public tender in research, development and innovation ALFA Technology Agency of
the Czech Republic
•InFuLOC - EU 7th Framework Programme – Marie Curie
•EU-CLAMP - EU 7th Framework Programme - Research for SMEs
BVT Technologies

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System evaluation and integration
BVT concentrates on the  technical solutions based on key know how in sensor technology. BVT
introduces  new systems in the market (miniRDE, thermodiffusion sensors, 3D-TFT) or set up the
devices based on the customer demand. The customer developed devices are produced in wide
collaboration with other companies.
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR
Program

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Glass electrochemical reactor developed on the commercial basis for BVT
BVT stirrer with improved mass transport
Standard commercial USB cable
Potentiostat developed by PalmSens instrument Netherlands www.palmsense.com
BVT connector KA1C
Program

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Support
Our customers need support. We concentrate to technological support of industrial and academic
partners and customers.  The examples of project where the customers used BVT support are in in
next slides. BVT also consider as very important training of customers in sensor technology.
MASS TRANSPORT TO SENSITIVE SURFACE
(pumps, ...)
IPR MANAGEMENT
(scientific and commercial projects, employees training, IPR audits, licence agreements)
SUPPORT
(specialized analysis, customer metodology development)
Components for device arrangement
(connectors, ...)
SYSTEM EVALUATION (potentiostats, software, signal processing, ...)
MICROFLUIDICS (flowcells, microchannels, ...)
SENSOR
Program

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Study of organohosphorus pesticides in field
BVT carried out the study of decomposition of organophosporus pesticides in collaboration with
Mendel University in Brno (http://www.mendelu.cz/cz). The service was done at special field where
the different concentrations of pesticide were applied. The project was supported by Czech ministry
of industry as project TIP - ANTOPE. The use of BVT technology enabled to analyze more than 500
different samples at significantly lower price than standard gas chromatography enables.
Date
Applied pesticides
19.4.2004
AFALON 45 SC
27.5.2004
METHANION 48 EM
16.6.2004
METHANION 48 EM
28.6.2004
DITHANE M 45
16.7.2004
METHANION + DITHANE
6.8.2004
METHANION + DITHANE
4527-odběr-maska
Program

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The use of sensors in field
BVT participated in the project, where it was necessary to study the thermal movement of the water
dam. It was necessary to make installations of the temperature sensors on the dam and the movement
sensors inside of the dam. The measurement proved the stability of dam. The final device is fully
automated and all data are accessible via internet.
The thermal movement of dam is on the above figure. It correlates with change of temperature during
day and with long term temperature changes.
IMG_1670
Program

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AERO_Desky-3
Thank you
Email: info@bvt.cz
Tel: +420 563 034 298
Web: www.bvt.cz

BVT Technologies
RNDr. Jan KREJČÍ, PhD.,
Chief of executive board