C8953
NMR structural analysis - seminar
INADEQUATE +
Stereochemistry
Michal Knor
437395@mail.muni.cz
May 5, 2021
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INADEQUATE
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• Incredible Natural Abundance DoublE QUAntum
Transfer Experiment
• INADEQUATE experiments are mainly used for 13C-13C
correlation spectra of natural abundance 13C molecules
• Low sensitivity
2D INADEQUATE - example
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Determine the structure of C10H18O using INADEQUATE exp.
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Determine the structure of C10H18O using INADEQUATE exp.
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Isomerism and NMR
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Relative stereochemistry on a ring: NOESY
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Relative stereochemistry on a ring: NOESY
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Interpretation of J-coupling
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Interpretation of J-coupling
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Interpretation of J-coupling: MYO isomer
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Determination of the absolute configuration of
stereogenic centers
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Determination of the absolute configuration of
stereogenic centers
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Determination of the absolute configuration of
stereogenic centers
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