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Jiří Damborský
National Center for Biomolecular Research
jiri@chemi.muni.cz, ph. 41129 377, Kotlářská 2, bid. 7, 2nd floor
Bioinformatics - what is it?
The term bioinformatics is used to encompass almost all computer applications in biological
sciences.
Information technology applied to the management and analysis of biological data
originally - analysis of sequence data (1980s)
presently - also analysis of 3D-structures
Bioinformatics - study material
Introduction to bioinformatics, T.K. Attwood and DJ. Parry-Smith, Longman, Essex, 1999
http://www.awl-he.com/biology
http://www.bioinf.man.ac.uk/dbbrowser/ bioactivity/prefacef rm. html
http://www.chemi.muni.cz/~jiri
Bioinformatics - arrangement
2 hours per week (12?? lectures in total)
■  1st hour = lectures - theory
■  2nd hour = training on computers - examples
Bioinformatics - lectures
Introduction Information networks Protein information resources Genome information resources DNA sequence analysis Pairwise sequence alignment Multiple sequence alignment Secondary database searching Analysis packages Protein structure modelling
Bioinformatics - practical training
■  Databases
■  Searching and modelling servers
■  Building a sequence search protocol
■ Case examples (sequences)
■  Protein structure prediction Protein modelling
Follow-up of lectures
Bioinformatics - examination
Written test: 100 questions (1 point / question)
100-90 points = 1 89-80 points = 2 79-60 points = 3
Oral examination: example sequence -> search, analysis, modelling, prediction (in Czech or in English)