Membrane lipid domains

•           Domains are regions with distinctive physical features and compositions

–     Coated pits (clatrin coat – internalization)

–     Caveolae (flask shaped invaginations, caveolins, cholesterol)

–     Lipid rafts (cholesterol, sphingolipids, GPI anchored proteins)

•           Domains have wide range in composition, size and dynamics

                                     Definition of lipid rafts