Doc. Ing. Stanislav Kafka, CSc., Ústav chemie, Fakulta technologická, Univerzita Tomáše Bati, Zlín


Quinoline-2,4(1H,3H)-dione as a target for Wittig reactions and further transformations


In the last two decades, the reactivity of quinoline-2,4(1H,3H)-diones has been explored rather
intensively. These studies, among them the investigations intent on Wittig reactions constitute one
of the most marked fields, have led to a number of interesting products. As could be expected,
Wittig reactions enable to transform quinoline-2,4(1H,3H)-dione in structures, which are
interesting from various aspects, e.g. structural patterns occurring in many compounds displaying
appreciable bioactivity. Especially intramolecular Wittig reaction represents an efficient tool for
the creation of new tricyclic systems with heteroatoms. On the other hand, depending on the
substitution of basic scaffold, the Wittig reaction could be more or less accompanied by side
reactions, even other reaction can take place instead of the Wittig reaction. Also the explorations
of side products have earned a number of interesting findings.