Adrenalin:
OH
OH
1. ClCH2COCl
AlCl3
2. MeNH2
OH
OH
H2, kat.
O
NHMe
OH
OH
HO
NHMe
kyselina
(+)-vinná
OH
OH
(R)-(-)-adrenalin
NHMe
OH
OH
(S)-(+)-adrenalin
NHMe
rac-adrenalin
HO
HO
oxidace
Noradrenalin:
Fenylefrin:
Dobutamin:
Ibopamin:
Salbutamol:
COOMe
O
COOMe
O
N
HO
NCl
OH
Ph
t-Bu
OH
t-Bu
Ph
OH
OHLiAlH4
t-Bu
HN
Ph
HO
H
N
t-Bu
OH
OH
H2, Pd/C
OH
COOMe
Cl
O
Cl
AlCl3
Aryloxyaminopropanoly:
O
ClArOH +
NaOH O
ArO
i-Pr-NH2
ArO NH-i-Pr
OH
Benzokain a prokain:
Bupivakain:
bupivakain
N COOH
ClCOOEt,
báze
N
O
O
O
OEt
Me
H2N
Me
N
H
N
Bu X
1. H2, Pt
2. OH-
rac-bupivakain
kyselina
dibenzoyl-D-vinná
(S)-bupivakain
O
Me
Me
N
H
N
O
Me
Me
N
H
N
O
Me
Me
Bu
+
X-
Bu
N
H
N
O
Me
Me
Bu
N
H
N
O
Me
Me
Bu
Acetylcystein:
Mesna:
Bromhexin: