Masaryk University
PRINCIPLES OF FIRE PROTECTION
AND SAFE HANDLING OF CHEMICALS
Editors: Mgr. Jaromír Literák, Ph.D.
Ing. Barbora Loučková
prof. RNDr. Jiří Příhoda, CSc.
Brno 2017
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FIRE PREVENTION AND PROTECTION
Obligations and responsibilities focusing on fire prevention:
▪ to act in such a way that does not cause the fire occurrence and does not endanger lives and
health of persons, animals and properties; especially when using heating, electrical, gas and
other appliances and equipment or when storing, handling or using flammable or fire
hazardous substances over when handling open fires,
▪ observe conditions or instructions related to fire safety of products or activities,
▪ ensure continued access to fire extinguishers, hydrants, power distribution systems and gas,
water and heating system valves,
▪ follow orders and observe bans ensuring fire safety at designated or fire-hazardous
locations,
▪ not to damage, and maintain usable fire prevention items (portable fire extinguishers) and
fire safety devices (e.g. hydrants), know their locations and methods of applications,
▪ when you see fire try to extinguish it with all available means. If not possible, immediately
take measures to prevent the spread of fire and report the fire to the fire brigade (phone 150)
or to the fire protection centre (extension 2929) and to a supervisor. Sound the fire alarm
(by calling "FIRE"), by using the EPS emergency button or automatically, by using the
electronic fire alarm sensor,
▪ after the fire breaks out follow instructions of the employee who handles the fire
extinguishing process (or evacuation) and upon the arrival of the fire brigade follow
instructions of the fire brigade commander,
▪ when fighting fire, natural disasters and other emergencies provide adequate personal and
material assistance (unless such activity would pose a serious danger to you or to your loved
ones, or if an important circumstance prevent such assistance);
▪ report shortcomings or deficiencies which could jeopardise fire safety to your supervisor
and participate to the best of your knowledge and efforts in the removal of such deficiencies,
▪ report to your supervisor all fires, even those you managed to put out by yourself,
▪ when using electrical heaters, stoves, or machines follow instructions in the manufacturer’s
manual and valid fire prevention regulations with which you have been acquainted,
▪ before leaving the workplace, take precautions to avoid fire, emergency situations, or
property damage.
Prohibited activities:
deliberate and unreasonable calls to the fire brigade, abuse of the emergency phone line,
▪ performing work activities that may result in fires or lead to emergency situations providing
that the given person does not possess the required professional skills, in particular, repairs
or inappropriate interventions into electrical and heat producing appliances and equipment,
▪ installation and use of electrical and thermal equipment and appliances not approved by the
employer,
▪ restricting or completely disabling the use of marked boarding areas used by fire-fighting
equipment,
▪ damaging, misusing or otherwise preventing the use of fire extinguishers, hydrants and fire
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safety devices and main shutters, valves and switches (electric power, water, gas), e.g. by
storing material in front of these devices, or by installing furniture in front of them.
▪ burning out vegetation or grass-covered areas.
Burning process
Burning is a physicochemical oxidation reaction in which the flammable substance reacts with
an oxidising agent. This reaction is accompanied by the release of heat, light and by combustion
emissions.
Burning process starts and takes place under certain conditions. In order to achieve the
burning process, three conditions (the so-called burning or fire triangle) needs to be
present:
▪ flammable substance (fuel),
▪ oxidising agent (air, oxygen),
▪ ignition source (heat).
Figure 1 Fire triangle
Instructions for the use of portable fire extinguishers
Instructions how to use a particular fire extinguisher are always shown on the fire extinguisher
body. All fire extinguishers are used in close proximity to the fire.
1. Remove the fire extinguisher from the holder and bring it near to the fire.
2. Remove
the safety
fuse
3. Focus on the fire base 4. Press the lever 5. Spray from side to
side
approximately 1.5 m
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▪ Always spray in the direction of the wind (draft)!
▪ Starts praying from the bottom and aim into the burning centre. Never spray the flames!
▪ Use short controlled bursts. Never use all the extinguishing agent at once!
▪ If in an enclosed area make sure to have the door behind you (make sure to have a free
escape route)!
Fire class A:
Burning organic solids accompanied by heat radiation, such as wood, paper, straw,
coal, rubber, textiles, plastics etc.
Fire class B:
Burning liquids or substances which turn into liquid such as petrol, oil, paint,
alcohol, wax, etc.
Fire class C:
Burning gases for example methane, propane, acetylene, hydrogen.
Fire class D:
Burning combustible metals such as aluminium, magnesium, potassium, sodium.
Fire class F:
Burning edible oils and fats - vegetable or animal fats in fryers and in other kitchen
appliances and equipment.
Fire
extinguisher
type
Use for Never use for
Water
solid organic items/substances (paper,
wood, textiles) alcohols
devices under electric power, acids,
vegetable fats and oils
Powder
flammable solids, liquids, oils, petrol,
devices under electric power
(universal extinguishing agent)
light and flammable alkaline metals
Foam
solid organic substances, petrol,
diesel, mineral oils and fats
devices under electric power, light
and flammable alkaline metals
Carbon
dioxide
devices under electric power
flammable dust, loose powdery
materials
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Inner wall hydrant
A fire water hydrant is an independent source of water intended for fire extinguishing but it
must never be used to put out fire of electrical equipment under voltage. Water hydrant is a part
of the mandatory fire protection system and represents the most important component of the
fire prevention and protection system. It is mostly used for the first and initial fire fighting
activities before the arrival of professional fire-fighters. May also be used by the public, if
necessary - it is not intended for professionals only. The length of fire hoses in the hydrant
varies. It is usually around 20 m and the spraying distance is 10 m.
open the hydrant cabinet / box
open the valve
unwind the hose
turn the water on by turning the
nozzle of the hose to the left
How to put out fire correctly
How to put out fire Correctly Incorrectly
Extinguish the fire
by applying the
extinguishing agent
in the same
direction as the
wind
Start at the edge of
the fire
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Extinguish dripping
or pouring
substances from top
to bottom
Extinguish burning
walls from bottom
to top
When using several
extinguishers use
them at the same
time and not
separately
Make sure the fire
will not start again
After each use make
sure the extinguisher
is refilled. Do not
return empty
extinguisher back on
the holder
How to proceed when a fire occurs
▪ In the event of fire it is necessary to follow the fire emergency guidelines which are
publicly available at each workplace and which define activities of employees and other
persons in the event of fire.
▪ Anyone who sees a fire is obliged to use all available means to extinguish the fire. If the
given person is not able to put out the fire using all available means, the person is obliged
to call a fire alarm and notify persons near the vicinity of the fire to assist during the fire
extinguishing process or to leave the endangered area.
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Method and location of fire reporting
Everyone is required to report a fire or to make sure that the given fire is reported to a fire
station of the individual City Hall or to the fire centre in Brno.
The report must specify who is calling, where the fire has occurred, and what is burning.
How to announce fire alarm
A fire alarm is announced or called
▪ automatically, by the FIRE SIGNAL electric
sensor
▪ by using the ELECTRICAL FIRE SIGNAL
pushbutton
▪ by calling "F I R E”
Evacuation and fire-fighting assistance
Evacuated people shall gather in the designated open space and wait for further instructions. By
the time the firefighters arrive, each person is obliged to provide adequate personal assistance
(unless he or she expose himself to a serious danger) and to take the necessary measures to
prevent the spread of fire.
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Handling chemical substances and mixtures at the Masaryk
University
1. Introduction
Handling chemical substances in the Czech Republic and the EU is regulated by a number of
laws. Their purpose is to protect people's health and the environment. The following
instructions are based on Regulation (EC) No. 1272/2008 of the European Parliament and of
the Council focusing on classification, labelling and packaging of substances and mixtures
(CLP) and its amendments (European Parliament and Council Regulation No. 487/2013), Act
No. 350/2011 Coll., on chemical substances and mixtures and Act No. 205/2020 Coll., which
amends Act No. 258/2000 Coll. on the protection of public health.
2. Chemicals and chemical mixtures labelling
From the point of view of the Regulation of the European Parliament No. 1272/2008 on the
classification, labelling and packaging of chemical substances the actual physical hazards of
chemical substances or mixtures with regards to health and the environment may be
characterised in more general terms by using the so-called hazard classes. There are 28 hazard
classes in the EU which may be further divided according to physical hazards, hazards to human
health or risks to the environment. Each hazard class is divided into one or more hazard
categories that further define the nature and severity of the hazard. Based on CLP regulations
each hazard category is assigned with the following elements:
• one or more standard statements on the severity of the hazard (H phrase) which
describes the nature of the hazard of the given substance or mixture, including the
hazard/risk degree. H-phrases replace the former R-statements.
• one or more hazard warning symbols, which provide graphic information about the
type of the hazard by means of a symbols and other elements. Hazard warning symbols
represent certain hazard classes and categories whereas one symbol may refer to
multiple hazard categories.
• Signal word indicates the seriousness of the level of the warning against potential
danger; there are two levels: the word "danger" refers to more serious hazards; and the
word "warning" refers to a less serious hazard category.
• Safe handling instructions (P-phrases, precautionary statements) which have a defined
form and communicate information on hazard prevention, about responses to injury or
accident, and about safe storage and disposal of the given substance or mixture. These
are similar to the earlier S-sentences.
The characteristics of all hazard classes, the list of hazard categories and associated danger
symbols and signal words are given in annex No. 1. Annex No. 2 provides the list of H-phrases.
Annex No. 3 provides the list of P-phrases.
Information on the classification of a specific chemical or mixture by using hazard categories
together with a complete list of H- and P- phrases, warning symbols and signal words may be
found in the safety data sheet of the given substance or mixture.
9
The obligation to classify, label and package chemicals under the CLP Regulation applies to
manufacturers and importers, suppliers and the so-called downstream users who use the
substance or mixture in their industrial or professional activities. Certain chemicals and
mixtures which are carcinogenic, mutagenic, harmful to reproduction or sensitise the
respiratory tract must be uniformly classified across the entire EU. The list of these substances
and their classification may be found in the annex attached to the CLP Regulation.
The CLP Regulation does not apply to the following types of substances and mixtures:
radioactive substances and mixtures, substances and mixtures subject to Customs supervision
and which are temporarily stored for the purpose of export or which are in transit, non-isolated
intermediate products, substances and mixtures intended for scientific research and
development which are not sold on markets, waste, exemptions defined by Member States for
the purpose of defence, human and veterinary medicines, medical devices, beauty products,
food items, animal feeds and food supplements.
These chemicals and mixtures are generally commercially available in suitable and properly
marked packages. These packages are designed to meet the requirements on safe transport and
storage. The packaging of the chemical or mixture is equipped with a label which contains the
following information:
• Name, address and telephone number of the supplier,
• amount of substance or mixture in the package,
• product identifiers,
• any required hazard warning symbols,
• any required signal word,
• any standard hazard phrases,
• any precautionary phrases,
• any additional information necessary
Generally, a chemical packaging containing less than 3 litres should carry a label at least 52
74 mm in size. The warning symbol must cover at least 1/15 of the label area, but at least 1
cm2. If the packaging does not exceed 125 ml, the H- and P-phrases (the list of these categories
is available in CLP Regulation) may be omitted for selected classes of dangerous substances
and mixtures.
If a new packing is created by MU workers or students (if the old packaging breaks or the
chemical spills over when changing the packaging into a smaller unit, or when preparing
solution, mixtures, etc.), it is necessary to create own label. The elements on the label must
match the substance or mixture classification in line with the CLP Regulation. More
information on the classification and concentration limits required for the classification of
mixtures may be found in the CLP Regulation. MU uses relevant software to create new labels,
which is available in all involved workplaces, or it may be requested from the persons
authorised to supervise the handling of chemical substances at the given faculty / workplace
(see item10 of these guidelines)
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3. Instructions on safe handling of chemicals and mixtures
Based on the Act No. 205/2020 Coll., which amends Act No. 258/2000 Coll. on the protection
of public health:
• Legal and physical persons are required to protect human health and the environment
while handling chemical substances and to observe danger symbols and H and P
phrases.
• Nobody may sell, give or otherwise provide to other natural persons substances or
mixtures classified as acutely toxic under category 1 or 2.
• Nobody may offer, donate, sell or otherwise deliver, dispose of or somehow provide a
natural person under the age of 18 or a person whose legal capacity is limited by the
court, with chemicals and mixtures classified as acutely toxic under category 3 or target
organ systemic toxicants after single or repeated exposure category 1, corrosive labelled
with standard phrase H314.
• Legal entities and business individuals may handle highly toxic chemicals or mixtures
(acute toxicants under category 1 or 2) if overseen by professionally qualified natural
person. Individual activities may also be performed by an employee who has been
trained by the professionally qualified person. This training shall be conducted at least
once a year for 2 years. A written record of the training must be archived for 3 years.
• Chemical substances and mixtures classified of acute toxicity, category 1 or 2 must be
stored in lockable rooms secured against theft and entry of unauthorised persons. Mutual
harmful effects or misplacement of stored substances must be eliminated as well as
leakage into the environment including danger to individuals.
• The consumption of substances and mixtures classified as hazardous under acute
category 1 or 2 must be recorded. These records must be kept separately for each
substance and must include data on the quantity received and released, inventory status
including the name of the person to whom the chemical or mixture was given. Records
shall be kept for at least 5 years after the stock has been completely exhausted.
Natural persons professionally qualified to deal with highly toxic substances and mixtures
pursuant to Act No. 267/2015 Coll., are:
1. University graduates who:
• have completed a university degree through an accredited master study programme in
general medicine, dentistry / stomatology, pharmacy or through accredited master
degree programmes in the field of veterinary medicine and hygiene or public health
protection, or
• have obtained a university degree in the field of chemistry,
• have obtained a university degree focusing on teaching and specialising in chemistry,
• have obtained a university degree and have a certificate of completion for a lifelong
education in the field of toxicology,
• have obtained a university degree through an accredited master programme in biology,
11
ecology and environmental science focusing on phytopatology or on plant protection or
possibly focusing on lifelong learning in this field.
2. natural persons who have successfully passed a professional proficiency test and possess a
certificate of professional competence authorising them to handle chemical substances and
chemical mixtures classified as highly toxic.
The rules focusing on hazardous chemicals and mixtures handling and which have been
discussed with the JMK Regional Hygiene Administration may be found at the following
website: http://www.rect.muni.cz/nso/. These rules shall be available in printed form at all
workplaces. Each MU workplace may also have its own specific rules that supplement and
adapt these general university rules to the conditions of the particular workplace.
A specific feature of many of MU workplaces is that not only commercially available chemical
substances and mixtures are handled here, but that they are also prepared in small quantities
and new substances whose properties are not know yet are studied and investigated here. When
handling these substances and mixtures the necessary precautionary and general principles must
be observed. The basic requirement is to minimise the exposure of natural persons to these
substances, to prevent substance release into the environment and to anticipate their hazardous
physiochemical properties.
General work rules observed in a chemical laboratory:
• While working it is necessary to follow principles of good laboratory practice.
• Only qualified people have access to the laboratory. Guest only when accompanied by
a qualified person. Others are forbidden to enter the laboratory.
• Pregnant women are not allowed in the laboratory. Further, women who gave birth may
only enter the laboratory 9 months after delivery. Each woman is immediately required
to report pregnancy to the head of the workplace.
• Only work related to the character and purpose of the laboratory may be performed in
the laboratory.
• It is forbidden to eat, drink and store food in the laboratory. It is also forbidden to use
laboratory tools and ware for food storage. The laboratory provides a designated room
for food handling. Each worker must thoroughly wash their hands before eating,
drinking and smoking - work breaks and after work.
• Every lab worker must use appropriate work equipment, which he or she is obliged to
wear throughout his / her work and based on the nature of the given work (protective
goggles, shield, gloves, etc.). Protective equipment must always be worn when handling
substances that can cause burns or frostbites and also when using corrosive substances
and substances under high pressure or when handling appliances that use vacuum.
• Laboratories where steel gas bottles are stored must be equipped with a sign specifying
the type of the used gas.
• Only properly trained persons may connect appliances to power supply. It is prohibited
to modify or change any electric appliances. Only properly qualified personnel may
repair electrical devices or systems. Defects in distribution networks (water, gas, electric
12
power), must be reported to the laboratory manager or to the workplace manager
immediately. In UKB to PCO.
• It is forbidden to handle chemicals with unprotected hands (laboratory spoons are used
to collect solids); corrosive, toxic and infectious agents shall be picked by a measuring
cylinder or by safety pipettes.
• After the chemical is picked up, it is necessary to properly seal the bottle immediately
to avoid leakage of airborne pollutants and to avoid misplacement or confusion of
chemicals.
• Any handling of substances producing fumes, irritants, smells and toxic gases may only
be carried out under activated fume hood.
• Substance incineration or annealing may only be carried out under fume hood. The same
applies to production of hydrogen sulphide which is highly poisonous.
• Corrosives may not be stored at a height greater than the height of the worker's shoulders
who is handling the corrosives (no more than 165 cm).
• When handling substances in open containers (e.g. test tubes) it is necessary to keep the
neck of the tube/container away from your face while making sure that the container
does not point towards other workers.
• When a harmful substance is spilled it must be disposed of immediately.
• Spilled nitric acid may not be removed using sawdust, rags and other organic materials.
Before the removal nitric acid must be neutralised and if this is not possible it must be
diluted as much as possible. Dishes contaminated with organic matter cannot be cleaned
with nitric acid (danger of violent reactions, production of nitrogen oxides and danger
of self-ignition).
• Spilled acids, especially concentrated acids, must be first carefully diluted with water,
slightly neutralised with carbonate (e.g. sodium bicarbonate, chalk, etc.), or by spraying
with diluted alkali solutions, followed by careful flushing with water or by allowing the
liquid to be absorbed by sawdust, rags, etc. When cleaning make sure not to contaminate
too large area.
• Spilled perchloric acid must be strongly diluted with water and non-flammable material
must be used to wipe it out. Never use cotton or cellulose material. The material which
was used to wipe out the perchloric acid must be thoroughly washed under running
water.
• Perchloric acid shall be stored in a bottle with sanded neck and separately from other
chemicals, especially organic chemicals. Perchloric acid bottles should not be placed on
wooden racks, but on glass, porcelain, ceramic or other fireproof and non-absorbent
pads allowing easy removal of possible spills.
• When a flammable liquid is spilled immediately turn off open sources of heat,
disconnect electrical appliances from the power grid, and dispose of the spill in a
qualified manner. The liquid should be absorbed by a porous material and the material
shall be transported to a safe place. Non-polar solvents spilled on PVC flooring cannot
be cleaned by wiping the spill out (danger of static electricity). When large amount of
solvent is spilled workers who do not participate in the cleaning must leave the
laboratory.
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• Chemical dishes that have been used to handle toxic or corrosive substances must be
rinsed thoroughly before further use. All bottles which contained toxic substances must
be cleaned of any remaining contents before their disposal.
• When distilling flammables, it is necessary to move any bottles with flammable
substances and other chemicals to a safe distance and shut down all sources of open
flame. Flammables cannot be heated using an open fire /burner. Water / oil baths, heating
mentles or heat sinks are used to heat flammables. The temperature must be kept below
the flash point. If water enters the oil bath turn off the heating process immediately and
replace the bath.
• When diluting acids always pour the acid into water and never the other way around!
Pour the acid slowly and carefully while constantly stirring the liquid, especially
sulphuric acid. When dissolving solid hydroxide, the hydroxide must be poured in small
portions into water while stirring. Never pour water onto the hydroxide.
• When handling glass (removing plugs, attaching hoses, etc.), it is necessary to protect
yourself from injury. Hose cannot be fitted on tubes or thermometers when dry and by
applying direct pressure. Instead turn the hose right to left while sliding it on a wetted
glass surface.
• Before using vacuum or pressure make sure that only undamaged dishes and parts are
installed in the in the given apparatus.
• Be aware of the danger of the formation of explosive peroxides in substances that are
easily oxidised by air under light (ethers, unsaturated hydrocarbons). Especially before
distillation of substances from older packages it is recommended to perform a test
confirming the presence of peroxides. Peroxides may be detected with a solution of
potassium iodide or starch paper impregnated with potassium iodide.Apositive reaction
is manifested by the formation of elemental iodine (solution turns pink) or the paper
turns blue. Peroxides may be removed by shaking the liquid in a water solution with
ferrous salt. Empty bottles of ethers from which their contents have evaporated over a
long storage period may pose danger as well.
• Packaging which do not clearly specify what type of chemical they contain must be
disposed of in a qualified manner and immediately.
4. Fire handling procedure:
• Escape routes from the laboratory and handling areas must be permanently free any
obstacles - make sure to maintain work desks, fume hoods, the floor and the entire
laboratory clean and in order.
• If a fire occurs stay calm and try to extinguish minor accidents by extinguishing the flame,
using a fire mask or dust cover or use suitable fire extinguisher More detailed information
how to extinguish a certain type of fire based on the used chemicals and type of work may
be found in safety data sheets.
• If a fire occurs, first remove pressurised steel bottles containing gas.
5. Safety data sheet
Material safety data sheet (MSDS) for chemical substances and mixtures is a basic information
14
document providing summarised data about the manufacturer or importer and about hazardous
properties of the chemical or the mixture, as well as data necessary for the protection of human
health and the environment. Indicates possible risks and specifies personal protective
equipment required for safe use.
The content of safety data sheets and requirements for their preparation are specified in detail
in REACH (Regulation of the Commission No. 1907/2006) and in the amendment to this
Regulation (Regulation of the Commission No. 453/2010).
The safety data sheet allows users of chemicals and mixtures to take the necessary measures
needed to protect human health and the environment and to ensure safety at work.
It is recommended that you demand it when ordering the substance for the first time or
download it from the manufacturer's / seller website. It is advisable to store data safety sheets
at the workplace so that all workers have access to them, and to implement a suitable system
allowing everyone to quickly find the given data sheet.
6. List of highly hazardous substances
Each workplace shall prepare a list of substances and mixtures that are classified as corrosive
or Target organ systemic toxicants after single or repeated exposure belonging to category 1,
carcinogenic category 1 or 2, mutagenic category1 or 2, reproductive toxicants category 1 or 2,
germ cell mutagens category 1A or 1B, reproductive toxicants category 1A or 1B and acutely
toxic category 1 or 2 which are stored or use at the given workplace. The list shall be stored in
an electronic database and must be continuously updated. The update period cannot be longer
than one year. A person responsible for supervising the handling of chemicals at the given
faculty / workplace shall be responsible for the accuracy and timeliness of the records (see the
list at the end of these rules).
7. General rules on waste management and processing
Waste may only be stored in containers that are properly labelled - as required by the given
legislature. Labelling must match the nature of the waste stored in the container. Only watermiscible
chemicals may be poured into the sink and only in quantities which do not pose any
risk to rivers or to the water sewage system such as water-soluble solvents up to 0.5l (diluted at
least 10 times), acids and hydroxides (diluted 30 times, pH should remain within 6.5 - 8.5).
Corrosives, acids and hydroxides may only be poured into sink while the water faucet runs.
Water-immiscible solvents which are toxic, flammable and explosive, concentrated acids and
hydroxides and compounds releasing toxic or irritant fumes on contact with water, and heavy
metal solutions cannot be poured into the sink. Do not place fire-hazardous substances in waste
containers.
Each workplace shall dispose of chemical waste at regular intervals or through a supplier. Each
workplace shall arrange for waste disposal through a company that the deals with the disposal
of chemical waste. Reimbursement for the disposal of waste shall be paid by the given
workplace.
8. Training for faculty students and staff focusing on hazardous chemicals and mixtures
handling
Physical persons who are not professionally qualified to handle highly toxic substances and
15
mixtures pursuant to Act No. 258/2000 Coll., but who in the course of their employment, or
while being trained for the employment at MU, handle hazardous chemical substances or
mixtures which are allocated to the hazard categories:
• Acute toxicity category 1 or 2
• Target organ systemic toxicity after single or repeated exposure category 1
• Carcinogenicity category 1 or 2,
• Germ cell mutagenicity category 1 or 2,
• Reproductive toxicity category 1 or 2,
• Germ cell mutagenicity category 1A or 1B
• Reproductive toxicity category 1A or 1B,
• corrosive,
must be demonstrably and properly introduced to and aware of the hazardous properties of the
given chemical substances or mixtures including requirements on health and environmental
protection against harmful effects of such chemicals and must be aware of first-aid application
principles.
The training for faculty students and staff focusing on hazardous chemicals and mixtures
handling may be divided into several stages:
• general training focusing on the handling of chemical substances and mixtures used by
students and employees,
• special training for students working in a specific practical exercise,
• training for students and employees dealing with highly hazardous chemicals or
mixtures.
General training for students of the relevant fields is organised by each faculty individually and
applies to all bachelor, master and postgraduate students who may come into contact with
dangerous chemical substances or mixtures during their studies or while working for a research
programme. The faculties have included in their curriculum a compulsory study programme
without providing any credits which uses and handles chemicals or chemical mixtures called
Chemicals and chemical substance handling. The credit from this study programme will serve
as proof of its completion. For first year students the general training is provided as a minimum
two-hour lecture. This lecture may be included as an introductory lecture of another lesson, or
it can be done separately. The attendance is recorded. However, senior students do not have to
attend this lecture and may obtain the necessary information at http://rect.muni.cz/nso.
All students must prove their general knowledge of the instructions defining handling of
hazardous chemicals and mixtures every year by passing a test that may be completed through
the MU information system. The result of the test is periodically recorded, and the students will
receive their credit if they attend the lecture focusing on handling of chemicals at least once
during their study.
Special training under individual practical exercises should always be conducted if the nature
of the exercise requires it. The head of the workplace in cooperation with the training supervisor
shall decide on the content of the training,
Foreign students shall be trained how to handle chemical substances at the given workplace by
16
their supervisor. The training is recorded – see http://rect.muni.cz/nso/.
Workplaces (institutes, separate workplaces) shall organise for employees a general type of
training once every two years. The given workplace is responsible for ensuring, recording and
for inviting the given lecturer. Training records and follow-up training reports must be kept for
3 years.
Should employees of the Masaryk University handle the above-mentioned substances and
mixtures they must be professionally qualified in line with Act No. 267/2015 Coll., or they must
be trained by a competent person. The workplace manager or supervisor shall maintain record
for any worker who handles any of the above dangerous substances or mixtures mentioned
above in order to be able to provide a personal record demonstrating that the given employee
has been trained to handle these substances. The personal training records must be kept for at
least 3 years after the last training. Repeated training shall be conducted at least once during 2year
period. Details how to fill out such personal record are available at http://rect.muni.cz/nso.
Occasional visitors, if they are briefly staying or working in the premises where dangerous
chemical substances, solutions or products are used, shall be informed by their escort.
9. First-aid assistance
General information on first-aid is available in Annex No. 4. Should the work involving
hazardous chemicals require such information but no relevant information on the first-aid is
found in the above documents, the given worker is obliged to obtain this information and
included it in the Rules for handling highly dangerous substances (see item 4 of these Rules).
10. MU persons authorised to handle chemical substances
These persons serve as an advisory body focusing on the handling of chemical substances at
MU and at individual faculties. Their responsibilities include supervision of the compliance
with legal standards relating to the handling of chemical substances, general training and testing
of students and staff involved in the specified subject, inspection activities, administration
management and contact with superior inspection bodies (e.g. KHS).
Managers of individual workplaces are responsible for making sure that the valid legislation,
internal regulations and instructions of MU are observed.
MU authorised person
Mgr. Jaromír Literák, Ph.D.
Department of Chemistry
Faculty of Science
Kotlářská 2
611 37 Brno
phone: 549 495 580
e-mail: literak@chemi.muni.cz
University campus Bohunice, Kamenice 5, pavilion A10, room 108
Representatives for individual Faculties:
Faculty of Science
17
Mgr. Jaromír Literák, Ph.D.
Department of Chemistry
Faculty of Science
Kotlářská 2
611 37 Brno
phone: 549 495 580
e-mail: literak@chemi.muni.cz
University campus Bohunice, Kamenice 5, pavilion A10, room 108
MU Faculty of Medicine
Doc. RNDr. Jiří Dostál, CSc.
Department of Biochemistry
Kamenice 5
625 00 Brno, Czech Republic
phone: 549 493 564
e-mail: jrdostal@med.muni.cz
location: University campus Bohunice, Kamenice 5, pavilion A16, room 114
MU Faculty of Education and Pedagogy
Mgr. Jiří Šibor, Ph.D.
Department of Physics, Chemistry and Vocational Education
Poříčí 7
603 00 Brno
phone: 549 497 725
e-mail: sibor@ped.muni.cz
location: building Y, room 03011
MU Faculty of Informatics
doc. RNDr. Irena Krontorád Koutná, Ph.D.
Centre for Biomedical Image Analysis
Botanická 68a
602 00 Brno
phone: 549 49 3969
e-mail: qkoutna@fi.muni.cz
location: University campus Bohunice, Kamenice 5 - building A3, room 111
CEITEC MU
Ing. Barbora Loučková
Central European Institute of Technology
Kamenice 753/5
625 00 Brno
phone: 549 49 8037
e-mail: 234665@mail.muni.cz
location: University campus Bohunice, Kamenice 5 - building A35, room 128
18
11. Important contact information
Authorised person for the Faculty of Science and MU
Jaromír Literák
e-mail: literak@chemi.muni.cz
phone: 549495580
Central Protection Panel at the Brno-Bohunice University Campus
extension 2929 (phone: 549492929) for emergency situations
extension 4450 (phone: 549494450) for non-emergency situations
RMU Protection and Safety Centre
www.rect.muni.cz/nso
Toxicological Information Center
phone: 224919293 or 224915402
Annex No. 1: Overview of hazard classes, hazard categories and
warning symbols
Classes associated with physical hazards:
Explosives include:
1. explosive substances and mixtures;
2. explosive products excluding devices containing explosive substances and mixtures in
such quantities or of such nature that their accidental ignition will not cause any
19
external damages by particle, fire, heat, smoke or noise outside of the given apparatus;
3. substances, mixtures and articles other than those specified under item 1 and 2 which
are manufactured to obtain a practical, explosive or pyrotechnic effect.
In addition, explosives are further divided into one of the ix subcategories, depending on the
type of hazard they represent.
Hazard class Hazard class and
category
code
Graphic symbol
code
Signal word
Explosive
Unst. Expl. GHS01 Danger
Expl. 1.1 GHS01 Danger
Expl. 1.2 GHS01 Danger
Expl. 1.3 GHS01 Danger
Expl. 1.4 GHS01 Warning
Expl. 1.5 Danger
Expl. 1.6
Flammable gases (including chemically unstable gases), gases or gaseous mixtures which have
flammable range with air at 20°C and under a standard pressure of 101,325 kPa. This hazard
class is divided into two categories where substances are placed based on test or calculation
results. Flammable gas, which is also chemically unstable, is also placed in one of the two
categories defined for chemically unstable gases.
Flammable gas
Flam. Gas 1 GHS02 Danger
Flam. Gas 2 – Warning
Aerosols, i.e. aerosol dispensers are containers which cannot be refilled, are made of metal,
glass or plastic and contain compressed, liquefied or dissolved gas under pressure, or they may
contain liquid, paste or powder and are fitted with a release mechanism which allows the
contents of the container to be dispensed as solid or liquid particles or as a gas suspension, in
the form of a foam, paste or powder, or in a liquid or gaseous state. For the purpose of
classification aerosols are considered flammable if they contain a component that is classified
as flammable:
• liquids with a flash point ≤ 93 °C, including flammable liquids,
• flammable gases
• flammable solids.
Aerosols are placed into one of the two categories of this class based on its components, based
on chemical combustion heat and, where appropriate, based on foam flammability test
(applicable to foam aerosols) and based on ignition distance test - in an enclosed space
(atomisers).
20
Flammable aerosol
Flam. Aerosol 1 GHS02 Danger
Flam. Aerosol 2 GHS02 Warning
Oxidising gases are any gases or gaseous mixtures which in general may cause or promote
combustion of other substances by providing oxygen more efficiently than air. This class
contains only one category.
Oxidising gas Ox. Gas 1 GHS03 Danger
Gases under pressure are gases stored in a vessel under a pressure of at least 200 kPa (pressure
gauge) or liquefied gases or liquefied refrigerated gases. The class is divided into four groups:
compressed gases, liquefied gases, dissolved gases and refrigerated liquefied gases.
Gases under
pressure
Press. Gas
(compressed
gas)
GHS04 Warning
Press. Gas (liquefied
gas)
GHS04 Warning
Press. Gas
(refrigerated
liquefied gas)
GHS04 Warning
Press. Gas (dissolved
gas)
GHS04 Warning
Flammable liquids are liquids with a flash point of no more than 60 °C. This class is divided
into three categories.
Flammable liquid
Flam. Liq. 1 GHS02 Danger
Flam. Liq. 2 GHS02 Danger
Flam. Liq. 3 GHS02 Warning
Flammable solids are solids that are readily combustible or may cause fire or may contribute
to the through friction. Easily ignitable solids are substances or mixtures in the form of powder,
granules or paste and are considered dangerous if they can easily ignite during a short contact
with the source of ignition, such as a burning match, and if they allow rapid flame to spread.
This class is divided into two categories.
Flammable solid
Flam. Sol. 1 GHS02 Danger
Flam. Sol. 2 GHS02 Warning
Self-reactive substances and mixtures are thermally unstable liquids, solids or mixtures
susceptible to strong exothermic decomposition even without the presence of oxygen (air). This
21
definition excludes substances and mixtures classified under this document as explosives,
organic peroxides or oxidising substances and mixtures. Substances falling into this hazard
class are further divided into seven categories (A to G).
Self-reactive
substance or mixture
Self-react. A GHS01 Danger
Self-react. B GHS01
GHS02
Danger
Self-react. CD GHS02 Danger
Self-react. EF GHS02 Warning
Self-react. G − −
Pyrophoric liquids are liquid substances or mixtures which self-ignite even in small amounts
upon contact with the air within five minutes. This class contains only one category.
Self-ignitable liquid Pyr. Liq. 1 GHS02 Danger
Pyrophoric solids are solid substances or mixtures which self-ignite even in small amounts
upon contact with the air within five minutes. This class contains only one category.
Self-ignitable solid Pyr. Sol. 1 GHS02 Danger
Self-heating substances or mixtures are liquids, solids or mixtures other than pyrophoric
liquid or solids that are capable of self-heating thanks to reacting with air and without any
energy supply; these substances or mixtures differ from pyrophoric liquids or solids because
they only catch on fire if in large quantities (kilograms) and after a long period of time (hours
or days). Self-heating of substances or mixtures leading to spontaneous ignition is caused by
the reaction of the substance or mixture with oxygen (air) and thanks to the generated heat
which not being discharged into the surrounding environment quickly enough. Self-ignition
occurs when the rate of the heat creation is higher than the heat loss and the self-ignition
temperature is reached. This class is divided into two categories.
Self-heating
substance or mixture
Self-heat. 1 GHS02 Danger
Self-heat. 2 GHS02 Warning
Substances or mixtures emiting flammable gases when in contact with water are solids or
liquid substances or mixtures that tend to become self-ignitable or tend to release flammable
gases in dangerous quantities when in contact with water. Based on tests, substances in this
class are divided into three categories
A substance or
mixture that emits
flammable gases
Water-react. 1 GHS02 Danger
Water-react. 2 GHS02 Danger
Water-react. 3 GHS02 Warning
22
when in contact with
water
Oxidising liquids are substances or mixtures which are not necessarily combustible in general
but by providing oxygen may cause or promote combustion of other substances. This class is
divided into three categories.
Oxidising liquid
Ox. Liq. 1 GHS03 Danger
Ox. Liq. 2 GHS03 Danger
Ox. Liq. 3 GHS03 Warning
Oxidising solids are substances or mixtures which are not necessarily combustible in general
but by providing oxygen may cause or promote combustion of other substances. This class
includes three categories.
Oxidising solid
Ox. Sol. 1 GHS03 Danger
Ox. Sol. 2 GHS03 Danger
Ox. Sol. 3 GHS03 Warning
Organic peroxides are liquid or solid organic substances which contain a bivalent group -O−Oand
which can be considered hydrogen peroxide derivatives where one or both hydrogen atoms
are replaced by organic radicals. The term organic peroxides includes mixtures of organic
peroxides (products) which contain at least one organic peroxide. Organic peroxides are
thermally unstable substances or mixtures which may be exothermically decomposed through
self-acceleration. In addition, they may have one or more of the following properties:
i) they may decompose through an explosion;
ii) they burn quickly;
iii) they are sensitive to an impact or friction;
iv) they react dangerously with other substances.
This class is divided into seven categories (A to G)
Organic peroxide
Org. Perox. A GHS01 Danger
Org. Perox. B GHS01
GHS02
Danger
Org. Perox. CD GHS02 Danger
Org. Perox. EF GHS02 Warning
Org. Perox. G − −
Substances or mixtures corrosive to metals are substances or mixtures that may
damage or even destroy metals through chemical reaction. The criterion is the rate of the
corrosion either on a steel or aluminium surface exceeding 6.25 mm per year and under a test
23
temperature of 55 °C when tested on both materials. This class contains only one category.
Substance or
mixture corrosive to
metals
Met. Corr. 1 GHS05 Warning
Classes associated with health hazards
Acute toxicity of a substance refers to adverse effects that occur after oral or dermal
administration of a single dose of the given substance or mixture, or after multiple doses
administered within 24 hours or after inhalation exposure of 4 hours.Acute toxicity hazard class
is divided into acute oral toxicity, acute dermal toxicity and acute inhalation toxicity. This class
is divided into four categories.
Acute toxicity
Acute Tox. 1 GHS06 Danger
Acute Tox. 2 GHS06 Danger
Acute Tox. 3 GHS06 Danger
Acute Tox. 4 GHS07 Warning
Skin corrosive are substances that cause irreversible damage to the skin, namely a visible skin
necrosis through the epidermis and to the dermis following the application of the test substance
for up to 4 hours. Corrosive reactions are typified by ulcers, bleeding, bloody scabs, and, by the
end of observation at 14 days, by discolouration due to blanching of the skin, complete areas of
alopecia, and scars. Histopathology shall be considered to evaluate questionable lesions.
Skin Irritation means the production of reversible damage to the skin following the pplication
of a test substance for up to 4 hours
This class is divided into two categories: corrosive substances (category 1) and irritants
(category 2). Categories of corrosive substances are further divided into three subcategories (A
to C).
Skin Irritation means the production of reversible damage to the skin following the
application of a test
Skin corrosive /
Skin irritation
Skin Corr. 1A GHS05 Danger
Skin Corr. 1B GHS05 Danger
Skin Corr. 1C GHS05 Danger
Skin Irrit. 2 GHS07 Warning
Serious eye damage / eye irritation. Serious eye damage refers to a damage to the eye tissue
or to a visual decay after application of the test substance to the anterior surface of the eye,
which is not fully reversible within 21 of the application. Eye irritation means the production
of changes in the eye following the application of test substance to the anterior surface of the
24
eye, which are fully reversible within 21 days of application The class is divided into two
categories: substances causing serious eye damage (category 1) and substances causing serious
eye irritation (category 2).
Serious eye damage /
eye irritation
Eye Dam 1 GHS05 Danger
Eye Irrit. 2 GHS07 Warning
Respiratory or skin sensitisation. Respiratory sensitising substances are substances which
give rise to airway hypersensitivity after inhalation. A skin sensitiser is a substance which, upon
contact with the skin, causes an allergic response. Substances which sensitise the airways are
placed into one category (category 1), which is further divided into two subcategories (1A and
1B). Substances which sensitise the skin are placed into one category (category 2), which is
further divided into two subcategories (A and B).
Respiratory / skin
sensitisation
Resp. Senns. 1 GHS08 Danger
Skin Sens. 1 GHS07 Warning
Germ cell mutagenicity. A mutation refers to a permanent change in the amount or structure
of genetic material in the cell. The term mutation refers both to hereditary genetic changes that
may be phenotypic, and to DNA changes, if known (including specific base pair changes and
chromosomal translocation). The terms mutagenic and mutagen are used for substances that
cause an increased occurrence of mutations in the population of cells or organisms. The class is
divided into two categories, category 1 is further divided into two subcategories (1A and 1B).
Germ cell
mutagenicity
Muta. 1A GHS08 Danger
Muta. 1B GHS08 Danger
Muta. 2 GHS08 Warning
Carcinogenicity. Carcinogen refers to a substance or a mixture of substances that cause cancer
or increase the incidence of cancer. Substances which have induced benign and malignant
tumours in well performed experimental studies on animals are considered also to be presumed
or suspected human carcinogens unless there is strong evidence that the mechanism of tumour
formation is not relevant for humans. Substances and mixtures of this class are placed into one
of the two categories. Category 1 is further divided into two subcategories (1A and 1B).
Carcinogenicity
Carc. 1A GHS08 Danger
Carc. 1B GHS08 Danger
Carc. 2 GHS08 Warning
Reproductive toxicity includes adverse effects on sexual function and fertility in adult males
and females as well as developmental toxicity in offspring. However, the class mutagenicity in
germ cells is used to classify substances and mixtures with proven genetic inheritance impacts
to offspring.
25
Under this classification system the reproductive toxicity is divided into two main groups:
adverse effects on sexual function and fertility, and adverse effects on the development of
offspring.
Certain toxic impacts on the reproduction cannot be unambiguously assigned either to sexual
function and fertility or to the offspring developmental toxicity. Nevertheless, substances or
mixtures with these effects or substances containing such chemicals are classified as toxic for
reproduction. This class is divided into three categories. Category1 is then divided into
subcategory 1A (known toxicity) and 1B (a substance which is suspected to produce these types
of effects). Category 2 includes substances with predicted negative reproductive and
developmental effects. The third category is a supplementary category and includes substances
with effects on or via lactation.
Toxicity for
reproduction
Repr. 1A GHS08 Danger
Repr. 1B GHS08 Danger
Repr. 2 GHS08 Warning
Lact. − −
Specific target organ toxicity − single exposure. Specific target organ toxicity (after single
exposure) refers to a specific, non-lethal target organ toxicity resulting from a single exposure
to the substance or mixture. All serious health effects that may impair the function, both
reversible and irreversible, immediate or delayed, are included. The classification process
identifies the substance or mixture which may be toxic for specific target organs, which as such
may create potential adverse health effects for persons exposed to that substance or mixture.
This class is divided into three categories.
Specific target organ
toxicity −
single exposure
STOT SE 1 GHS08 Danger
STOT SE 2 GHS08 Warning
STOT SE 3 GHS07 Warning
Specific target organ toxicity − repeated exposure. Specific target organ toxicity (repeated
exposure) refers to a specific toxicity to target organs resulting from repeated exposure to the
substance or mixture. All serious health effects that may impair the function, both reversible
and irreversible, immediate or delayed, are included. This class is divided into two categories.
Specific target organ
toxicity −
repeated exposure
STOT RE 1 GHS08 Danger
STOT RE 2 GHS08 Warning
Aspiration hazard. A class of substances or mixtures which may be toxic to humans upon
aspiration.Aspiration refers to the entry of a liquid or solid substance or mixture into the trachea
and into the lower respiratory tract either directly through the oral or nasal cavity or indirectly
from vomiting. Aspiration toxicity includes serious acute effects, such as chemical pneumonia,
26
various degrees of lung damage, or death after aspiration. This class contains only one category.
Inhalation hazard Asp. Tox. 1 GHS08 Danger
Hazard classes associated with environmental hazards
Hazardous to the aquatic environment. Acute aquatic toxicity means the intrinsic property
of a substance to be injurious to an organism in a short-term exposure to that substance. Chronic
aquatic toxicity is the ability of the substance to cause adverse effects on aquatic organisms
during exposure that are determined in relation to the life-cycle of the organism. The
classification of substances within this class consists of one category for acute toxicity and four
categories of chronic toxicity.
Hazardous to the
aquatic environment
Aquatic Acute 1 GHS09 Warning
Aquatic Chronic 1 GHS09 Warning
Aquatic Chronic 2 GHS09 −
Aquatic Chronic 3 − −
Aquatic Chronic 4 − −
Additional EU hazard classes
Hazardous to the ozone layer. A substance hazardous to the ozone layer refers to a substance
which, on the basis of the available knowledge about the substance and based on the predicted
or observed life and behaviour of the substance in the environment, may pose a threat to the
structure and functioning of the stratospheric ozone layer.
Hazardous to the
ozone layer
Ozone − Danger
Endocrine disruption for human health. Substances and mixtures fulfilling the criteria of
endocrine disruptors for human health based on evidence shall be considered to be known,
presumed or suspected endocrine disruptors for human health unless there is evidence
conclusively demonstrating that the adverse effects are not relevant to humans. Endocrine
disruptor means a substance or a mixture that alters one or more functions of the endocrine
system and consequently causes adverse effects in an intact organism, its progeny, populations
or subpopulations.
27
Endocrine disruption
for human health
CATEGORY 1 None Danger
CATEGORY 2 None Warning
Endocrine disruption for the environment. Substances and mixtures fulfilling the criteria of
endocrine disruptors for the environment based on evidence shall be considered to be known,
presumed or suspected endocrine disruptors for the environment unless there is evidence
conclusively demonstrating that the adverse effects identified are not relevant at the population
or subpopulation level.
Endocrine disruption
for the environment
CATEGORY 1 None Danger
CATEGORY 2 None Warning
Persistent, Bioaccumulative and Toxic or Very Persistent, Very Bioaccumulative
properties. A substance shall be considered a PBT substance when it fulfils the persistence
(substance features long degradation half-life in the environment), bioaccumulation
(bioconcentration factor in aquatic species is higher than 2 000) and toxicity (the long-term noobserved
effect concentration for marine or freshwater organisms is less than 0,01 mg/l, the
substance meets the criteria for classification as carcinogenic (category 1A or 1B), germ cell
mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B, or 2), other
evidence of chronic toxicity, as identified by the substance meeting the criteria for
classification: specific target organ toxicity after repeated exposure (STOT RE category 1 or
2), substance meets the criteria for classification as endocrine disruptor (category 1) for humans
or the environment) criteria. A substance shall be considered a vPvB substance when it fulfils
the persistence (substance features long degradation half-life in the environment) and
bioaccumulation (bioconcentration factor in aquatic species is higher than 5 000) criteria.
Persistent, Bioaccumulative and Toxic or
Very Persistent, Very Bioaccumulative
properties
PBT None Danger
vPvB None Danger
Persistent, Mobile and Toxic or Very Persistent, Very Mobile properties. PMT means a
persistent (substance features long degradation half-life in the environment), mobile (the
28
decadic logarithm of the organic carbon-water partition coefficient Koc is less than 3) and toxic
(the long-term no-observed effect concentration for marine or freshwater organisms is less than
0,01 mg/l, the substance meets the criteria for classification as carcinogenic (category 1A or
1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B, or
2), other evidence of chronic toxicity, as identified by the substance meeting the criteria for
classification: specific target organ toxicity after repeated exposure (STOT RE category 1 or 2)
substance or mixture. A substance shall be considered a vPvM substance when it fulfils the
persistence (substance features long degradation half-life in the environment) and mobility (the
decadic logarithm of the organic carbon-water partition coefficient Koc is less than 2) criteria.
Persistent, Mobile and Toxic or Very
Persistent, Very Mobile properties
PMT None Danger
vPvM None Danger
29
Annex No. 2: Hazard statements (H-statements)
H200 – Unstable explosives.
H201 – Explosive; mass explosion hazard.
H202 – Explosive, severe projection hazard.
H203 – Explosive; fire, blast or projection hazard.
H204 – Fire or projection hazard.
H205 – May mass explode in fire.
H220 – Extremely flammable gas.
H221 – Flammable gas.
H222 – Extremely flammable aerosol.
H223 – Flammable aerosol.
H224 – Extremely flammable liquid and vapour.
H225 – Highly flammable liquid and vapour.
H226 – Flammable liquid and vapour.
H228 – Flammable solid.
H240 – Heating may cause an explosion.
H241 – Heating may cause a fire or explosion.
H242 – Heating may cause a fire.
H250 – Catches fire spontaneously if exposed to air.
H251 – Self-heating: may catch fire.
H252 – Self-heating in large quantities; may catch fire.
H260 – In contact with water releases flammable gases which may ignite spontaneously.
H261 – In contact with water releases flammable gases.
H270 – May cause or intensify fire; oxidiser.
H271 – May cause fire or explosion; strong oxidiser.
H272 – May intensify fire; oxidiser.
H280 – Contains gas under pressure; may explode if heated.
H281 – Contains refrigerated gas; may cause cryogenic burns or injury.
H290 – May be corrosive to metals.
H300 – Fatal if swallowed.
H301 – Toxic if swallowed.
H302 – Harmful if swallowed.
H304 – May be fatal if swallowed and enters airways.
H310 – Fatal in contact with skin.
H311 – Toxic in contact with skin.
H312 – Harmful in contact with skin.
H314 – Causes severe skin burns and eye damage.
H315 – Causes skin irritation.
H317 – May cause an allergic skin reaction.
H318 – Causes serious eye damage.
H319 – Causes serious eye irritation.
H330 – Fatal if inhaled.
H331 – Toxic if inhaled.
30
H332 – Harmful if inhaled.
H334 – May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 – May cause respiratory irritation.
H336 – May cause drowsiness or dizziness.
H340 – May cause genetic defects
exposure cause the hazard>.
H341 – Suspected of causing genetic defects.
H350 – May cause cancer.
H351 – Suspected of causing cancer.
H360 – May damage fertility or the unborn child.
H361 – Suspected of damaging fertility or the unborn child.
H362 – May cause harm to breast-fed children.
H370 – Causes damage to organs.
H371 – May cause damage to organs.
H372 – Causes damage to organs through prolonged or repeated exposure exposure cause the
hazard>.
H373 – May cause damage to organs through prolonged or repeated exposure exposure cause
the hazard>.
H400 – Very toxic to aquatic life.
H410 – Very toxic to aquatic life with long lasting effects.
H411 – Toxic to aquatic life with long lasting effects.
H412 – Harmful to aquatic life with long lasting effects.
H413 – May cause long lasting harmful effects to aquatic life.
EUH 001 – Explosive when dry.
EUH 006 – Explosive with or without contact with air.
EUH 014 – Reacts violently with water.
EUH 018 – In use, may form flammable/explosive vapour-air mixture.
EUH 019 – May form explosive peroxides.
EUH 044 – Risk of explosion if heated under confinement.
EUH 029 – Contact with water liberates toxic gas.
EUH 031 – Contact with acids liberates toxic gas.
EUH 032 – Contact with acids liberates very toxic gas.
EUH 066 – Repeated exposure may cause skin dryness or cracking.
EUH 070 – Toxic by eye contact.
EUH 071 – Corrosive to the respiratory tract.
EUH 059 – Hazardous to the ozone layer.
EUH 201 – Contains lead. Should not be used on surfaces liable to be chewed or sucked by
children.
EUH 201A – Warning! Contains lead.
EUH 202 – Cyanoacrylate. Danger. Bonds skin and eyes in seconds. Keep out of the reach of
children.
EUH 203 – Contains chromium (VI). May produce an allergic reaction.
EUH 204 – Contains isocyanates. May produce an allergic reaction.
31
EUH 205 – Contains epoxy constituents. May produce an allergic reaction.
EUH 206 – Warning! Do not use together with other products. May release dangerous gases
(chlorine)
EUH 207 – Warning! Contains cadmium. Dangerous fumes are formed during use. See
information supplied by
the manufacturer. Comply with the safety instructions.
EUH 208 – Contains (name of sensitising substance). May produce an allergic reaction.
EUH 209 – Can become highly flammable in use.
EUH 209A – Can become flammable in use.
EUH 210 – Safety data sheet available on request.
EUH 380 – May cause endocrine disruption in humans.
EUH 381 – Suspected of causing endocrine disruption in humans.
EUH 401 – To avoid risks to human health and the environment, comply with the instructions
for use.
EUH 430 – May cause endocrine disruption in the environment.
EUH 431 – Suspected of causing endocrine disruption in the environment.
EUH 440 – Accumulates in the environment and living organisms including in humans.
EUH 441 – Strongly accumulates in the environment and living organisms including in
humans.
EUH 450 – Can cause long-lasting and diffuse contamination of water resources.
EUH4 51 – Can cause very long-lasting and diffuse contamination of water resources.
32
Annex No. 3: Precautionary statements (P-statements)
P101 – If medical advice is needed, have product container or label at hand.
P102 – Keep out of reach of children.
P103 – Read label before use.
P201 – Obtain special instructions before use.
P202 – Do not handle until all safety precautions have been read and understood.
P210 – Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P211 – Do not spray on an open flame or other ignition source.
P220 – Keep/Store away from clothing/…/combustible materials.
P221 – Take any precaution to avoid mixing with combustibles…
P222 – Do not allow contact with air.
P223 – Keep away from any possible contact with water, because of violent reaction and
possible flash fire.
P230 – Keep wetted with…
P231 – Handle under inert gas.
P232 – Protect from moisture.
P233 – Keep container tightly closed.
P234 – Keep only in original container.
P235 – Keep cool.
P240 – Ground/bond container and receiving equipment.
P241 – Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 – Use only non-sparking tools.
P243 – Take precautionary measures against static discharge.
P244 – Keep reduction valves free from grease and oil.
P250 – Do not subject to grinding/shock/…/friction.
P251 – Pressurized container: Do not pierce or burn, even after use.
P260 – Do not breathe dust/fume/gas/mist/vapours/spray.
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 – Do not get in eyes, on skin, or on clothing.
P263 – Avoid contact during pregnancy/while nursing.
P264 – Wash … thoroughly after handling.
P270 – Do no eat, drink or smoke when using this product.
P271 – Use only outdoors or in a well-ventilated area.
P272 – Contaminated work clothing should not be allowed out of the workplace.
P273 – Avoid release to the environment.
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P281 – Use personal protective equipment as required.
P282 – Wear cold insulating gloves/face shield/eye protection.
P283 – Wear fire/flame resistant/retardant clothing.
P284 – Wear respiratory protection.
P285 – In case of inadequate ventilation wear respiratory protection.
P231 + P232 – Handle under inert gas. Protect from moisture.
P235 + P410 – Keep cool. Protect from sunlight.
33
P301 – IF SWALLOWED:
P302 – IF ON SKIN:
P303 – IF ON SKIN (or hair):
P304 – IF INHALED:
P305 – IF IN EYES:
P306 – IF ON CLOTHING:
P307 – IF exposed:
P308 – IF exposed or concerned:
P309 – IF exposed or if you feel unwell:
P310 – Immediately call a POISON CENTER or doctor/physician.
P311 – Call a POISON CENTER or doctor/physician.
P312 – Call a POISON CENTER or doctor/physician if you feel unwell.
P313 – Get medical advice/attention.
P314 – Get medical advice/attention if you feel unwell.
P315 – Get immediate medical advice/attention.
P320 – Specific treatment is urgent (see … on this label).
P321 – Specific treatment (see … on this label).
P322 – Specific measures (see … on this label).
P330 – Rinse mouth.
P331 – Do NOT induce vomiting.
P332 – If skin irritation occurs:
P333 – If skin irritation or rash occurs:
P334 – Immerse in cool water/wrap in wet bandages.
P335 – Brush off loose particles from skin.
P336 – Thaw frosted parts with lukewarm water. Do no rub affected area.
P337 – If eye irritation persists:
P338 – Remove contact lenses, if present and easy to do. Continue rinsing.
P340 – Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341 – If breathing is difficult, remove victim to fresh air and keep at rest in a position
comfortable
for breathing.
P342 – If experiencing respiratory symptoms:
P350 – Gently wash with plenty of soap and water.
P351 – Rinse cautiously with water for several minutes.
P352 – Wash with plenty of soap and water.
P353 – Rinse skin with water/shower.
P360 – Rinse immediately contaminated clothing and skin with plenty of water before
removing clothes.
P361 – Remove/Take off immediately all contaminated clothing.
P362 – Take off contaminated clothing and wash before reuse.
P363 – Wash contaminated clothing before reuse.
P370 – In case of fire:
P371 – In case of major fire and large quantities:
P372 – Explosion risk in case of fire.
34
P373 – DO NOT fight fire when fire reaches explosives.
P374 – Fight fire with normal precautions from a reasonable distance.
P375 – Fight fire remotely due to the risk of explosion.
P376 – Stop leak if safe to do so.
P377 – Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378 – Use … for extinction.
P380 – Evacuate area.
P381 – Eliminate all ignition sources if safe to do so.
P390 – Absorb spillage to prevent material damage.
P391 – Collect spillage.
P301 + P310 – IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312 – IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel
unwell.
P301 +P330 + P331 – IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P302 + P334 – IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350 – IF ON SKIN: Gently wash with plenty of soap and water.
P302 + P352 – IF ON SKIN: Wash with plenty of soap and water.
P303 + P361 + P353 – IF ON SKIN (or hair): Remove/Take off immediately all contaminated
clothing. Rinse skin
with water/shower.
P304 + P340 – IF INHALED: Remove victim to fresh air and keep at rest in a position
comfortable for breathing.
P304 + P341 – IF INHALED: If breathing is difficult, remove victim to fresh air and keep at
rest in a position comfortable for breathing.
P305 + P351 + P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P306 + P360 – IF ON CLOTHING: rinse immediately contaminated clothing and skin with
plenty of water before removing clothes.
P307 + P311 – IF exposed: Call a POISON CENTER or doctor/physician.
P308 + P313 – IF exposed or concerned: Get medical advice/attention.
P309 + P311 – IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P332 + P313 – If skin irritation occurs: Get medical advice/attention.
P333 + P313 – If skin irritation or rash occurs: Get medical advice/attention.
P335 + P334 – Brush off loose particles from skin. Immerse in cool water/wrap in wet
bandages.
P337 + P313 – If eye irritation persists: Get medical advice/attention.
P342 + P311 – If experiencing respiratory symptoms: Call a POISON CENTER or
doctor/physician.
P370 + P376 – In case of fire: Stop leak if safe to do so.
P370 + P378 – In case of fire: Use … for extinction.
P370 + P380 – In case of fire: Evacuate area.
P370 + P380 + P375 – In case of fire: Evacuate area. Fight fire remotely due to the risk of
explosion.
35
P371 + P380 + P375 – In case of major fire and large quantities: Evacuate area. Fight fire
remotely due to the risk of explosion.
P401 – Store …
P402 – Store in a dry place.
P403 – Store in a well-ventilated place.
P404 – Store in a closed container.
P405 – Store locked up.
P406 – Store in corrosive resistant/… container with a resistant inner liner.
P407 – Maintain air gap between stacks/pallets.
P410 – Protect from sunlight.
P411 – Store at temperatures not exceeding … oC/…oF.
P412 – Do not expose to temperatures exceeding 50 oC/122oF.
P413 – Store bulk masses greater than … kg/… lbs at temperatures not exceeding … oC/…oF.
P420 – Store away from other materials.
P422 – Store contents under …
P402 + P404 – Store in a dry place. Store in a closed container.
P403 + P233 – Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 – Store in a well-ventilated place. Keep cool.
P410 + P403 – Protect from sunlight. Store in a well-ventilated place.
P410 + P412 – Protect from sunlight. Do no expose to temperatures exceeding 50 oC/122oF.
P411 + P235 – Store at temperatures not exceeding … oC/…oF. Keep cool.
P501 – Dispose of contents/container to …
36
Annex No. 3: General instructions for giving first aid
Principles for providing first aid to those exposed to chemical substances
doc. MUDr. Daniela Pelclová, CSc., MUDr. Alexandr Fuchs, CSc., MUDr. Miroslava
Hornychová, CSc., MUDr. Zdeňka Trávníčková, CSc., Jiřina Fridrichovská, prom. chem.
1. General principles of first aid
In providing first aid the first thing that must be protected is the safety of both the receiver
and provider! By all means avoid chaotic behaviour. The injured should be kept mentally
and physically calm. In providing first aid, the affected person should be kept warm.
1.1. Quick orientation:
The situation must always be evaluated with a view to your own safety and that of the
injured. Enter a contaminated area only if you have the proper protection ([self-contained
breathing unit], mask with proper filter, backup from other personnel, etc.)
ATTENTION! In the case of poorly-ventilated areas it must always be expected that the
area could be contaminated!
• In handling contaminated clothing or other objects, responsible persons must
always wear the proper protective clothing including gloves.
• First aid should not be given in the place where the accident happened because of
the danger of contamination of the provider
1.2. In situations where life is threatened, first undertake the resuscitation of the
injured and obtain medical assistance.
In these situations where life is in danger, first carry out resuscitation, then seek
medical assistance:
stopped breathing - immediately provide artificial respiration
stopped heart - immediately provide indirect heart massage
unconsciousness - lay victim down in stabilized position on side
1.3. Equipment:
For effective first aid, the necessary equipment and materials must be available at the site:
• adequate water (if there is no source of water, an emergency supply of about 10
litres per person),
• blankets or other textile material to protect the victim against chill and to modify
the position of the victim; keep extra reserve clothing including shoes on hand
• first aid kit (contents according to the type of dangerous substances found at the
workplace). The kit’s contents must be replaced before the expiration date of the
medicines and other materials it contains
37
1.4 In case of uncertainty on how to proceed, use the telephone contact for the Toxicology
Information Centre, Na Bojišti 1, 120 00 Praha 2: tel. 224 919 293, 224 915 402; give
information on the substances or the composition of the preparation from the original
packaging or from the safety data sheet of the substance or preparation.
1.5. If medical examination is necessary, bring along the original packaging with label, or
the safety data sheet of the given substance or preparation!
2. First aid in the event of contact with corrosives and other substances causing edema
of the lungs
In these situations where life is in danger, first carry out resuscitation, then seek
medical assistance:
stopped breathing - immediately provide artificial respiration
stopped heart - immediately provide indirect heart massage
unconsciousness - lay victim down in stabilized position on side
2.1. Inhalation (applies to substances that cause edema of the lungs)
• move the victim into the fresh air, quickly and with a view to your own safety; do
not let the victim walk!
• according to the situation, rinse out mouth or nose with water
• change the person’s clothes if they have come into contact with the substance
• keep the victim warm
• if the situation warrants, call an ambulance
• or obtain medical care; the patient must be monitored for at least another 24 hours.
2.2. Contact with eyes (applies to corrosives)
• immediately rinse eyes with flowing water, open eyelid (even by force); if the
victim has contact lenses, take them out immediately. Do not neutralize under any
circumstances!
• rinse for 10-30 minutes from the inner corner of the eye outward, so as not to
contaminate the other eye.
• If the situation warrants, call emergency services.
• or seek medical attention as soon as possible, preferably from a specialist.
• anyone affected must seek medical care, even if the case is minor
2.3. Contact with skin (applies to corrosives)
• immediately remove the affected clothing; before or during washing remove all
rings, watches, and bracelets, if present in the area where the skin is affected
• rinse the affected area with a flow of tepid water if possible for a period of 10-30
minutes; do not use a brush, soap, or neutralizer.
Note: when affected by substances for cauterizing properties, do not use
neutralizing solutions. Inactivating solutions can only be used with some
38
substances (for example, oil for lithium, sodium, potassium; potash for white
phosphorous; polyethylenglycol for phenols and cresols; calcium gluconate for
hydrofluoric acids and oxalics) or decontaminating powder (with yperite).
• Cover burned parts of the skin with sterile bandage, do not apply cream or other
treatment to the skin
• Cover the patient to keep him warm
• If the situation warrants, call emergency services
• Or seek medical attention
2.4. Ingestion
• DO NOT INDUCE VOMITING – danger of further damage to the digestive tract!!!
Danger of perforation of esophagus and stomach!
• IMMEDIATELY RINSE OUT MOUTH WITH WATER AND DRINK 2-5 dl of
cool water to ease the thermal effects of the corrosive substance.
• Because of the almost instantaneous effect on the mucous membrane, it is better to
give the victim water from the tap and not waste time trying to find cool liquids –
with each minute the condition is prolonged, the mucous membrane is irreparably
damaged! Soda or mineral waters are not suitable, as they may give off gaseous
carbon dioxide. Larger amounts of water should not be drunk, as this may induce
vomiting and possible breathing of corrosive substance into lungs).
• The victim should not force the drink, especially if he has pain in the mouth or
throat. In that case only rinse the victim’s mouth out with water.
• DO NOT USE CHARCOAL! (the blackening makes medical examination of the
digestive tract difficult and with acids and lyes does not have a positive effect).
• Do not give the person any food
• Do not put anything in the victim’s mouth if he is unconscious or has cramps
• If the situation warrants, call emergency services
• Or seek medical attention as soon as possible
3. First aid after ingestion of substances that may be harmful to lungs (petrol, diesel
fuel, kerosene, turpentine, solvent compounds with gasoline, etc.)
These are substances and preparations containing aliphatic, alicyklic, and aromatic
hydrocarbons, which have low viscosity and low surface tension, and are usually marked
with phrase R 65: Harmful to health; ingestion may cause damage to lungs.
In these situations where life is in danger, first carry out resuscitation, then seek
medical assistance:
stopped breathing - immediately provide artificial respiration
stopped heart - immediately provide indirect heart massage
unconsciousness - lay victim down in stabilized position on side
39
3.1. Inhalation
• end the exposure immediately, move the person into the fresh air (remove
contaminated clothing)
• arrange to keep the person warm
• arrange for medical examination; it will be necessary to maintain observation for at
least 24 hours
3.2. Contact with the skin
• remove contaminated clothing
• rinse the affected area with large amounts of water, tepid if possible
• if the skin has not been damaged, soap, soap solution, or shampoo may be used
• seek medical care
3.3. Contact with eyes
• immediately rinse the eye with flowing water, open the eyelid (by force if
necessary); if the person has contact lenses, remove them immediately
• keep rinsing for at least 10 minutes
• seek medical help, preferably from a specialist.
3.4. Ingestion
• DO NOT INDUCE VOMITING!
• If the victim vomits, take care he does not inhale vomited material (danger of lung
damage if even the smallest amount of these liquids are inhaled)
• obtain medical treatment, as the patient must often be monitored for at least 24
hours; bring along original container with label, or the safety data sheet of the given
substance.
4. First aid in case of contact with substances classified as toxic and highly toxic
In these situations where life is in danger, first carry out resuscitation, then seek
medical assistance:
stopped breathing - immediately provide artificial respiration
stopped heart - immediately provide indirect heart massage
unconsciousness - lay victim down in stabilized position on side
4.1. Inhalation
• end the exposure immediately, and move the person into the fresh air (be careful of
contaminated clothing)
• after exposure to hydrocyanic acids, have the victim inhale 1 or 2 ampoules of
Nitramyl (amylium nitrosum)
40
• Arrange to keep the person warm
• If the situation warrants, call emergency services
• and always get a medical examination
4.2. Contact with the skin
• remove contaminated clothing
• rinse the affected area with large amounts of water, tepid if possible
• if the skin is not damaged, soap, soap solution, or shampoo may be used
• if the situation warrants, call emergency services
• and always obtain a medical examination
4.3. Contact with the eyes
• immediately rinse the eye under flowing water; keep the eyelid open (by force if
necessary); if the victim is wearing contact lenses, take them out immediately.
• rinse for at least 10 minutes
• call emergency services
4.4. Ingestion
• AFTER INGESTING ANY HIGHLY TOXIC, SOME TOXIC, AND
SPECIFIC DANGEROUS SUBSTANCES, of which consumption of amounts
less than a gram or one gulp (30 ml) is life threatening) INDUCE VOMITING
(especially with cyanides, some anorganic metal salts, paraquat, diquat, methyl
alcohol, some organic solvents – benzene, tetrachloramethane, chloroform, carbon
disulfide, and other substances).
To induce vomiting: Induce vomiting only if subject is conscious, and within 1
hour after ingestion. Drink 1 – 2 dl of tepid water with a teaspoon of liquid soap
and powdered or crushed active charcoal, about 5 tablets equivalent. A larger
amount of water is not desirable, because if vomiting does not occur, the extra
water will help to dissolve and metabolize harmful substances soluble in water, and
washes the toxic substance even deeper into the digestive tract.
• If you are not sure whether to induce vomiting, contact the Toxicology Information
Centre and give them the data on the substances or preparations from the original
package or from the safety data sheet of the substance or preparation.
• AFTER INGESTING TOXIC OR HIGHLY TOXIC SUBSTANCES EAT
WITHIN 5 MINUTES 10-20 CRUSHED TABLETS OF ACTIVE CHARCOAL
MIXED IN WATER – regardless of whether vomiting has been successfully
induced or not
• if cyanide has been ingested, inhale 1-2 ampoules of Nitramyl (amylium nitrosum)
• call emergency services
41
5. First aid in case of contact with substances classified as harmful to health
5.1. Inhalation
• immediately end the exposure, move the person into the fresh air
• see that the person is kept warm
• obtain medical attention, especially if there is a persistent cough, shortness of
breath, or other symptoms
5.2. Contact with skin
• remove contaminated clothing
• wash the affected area with large amounts of water, tepid if possible
• if the skin has not been damaged, soap, soap solution, or shampoo may be used
• get medical attention, especially if skin irritation persists
5.3. Contact with eyes
• immediately rinse eye with flowing water, keep eye open (by force if necessary); if
the person has contact lenses, remove them immediately.
• rinse eye for at least 10 minutes
• get medical attention, from a specialist if possible
5.4. Ingestion
• DO NOT INDUCE VOMITING – the inducing vomiting itself may cause
complications (inhalation of substance into lungs and respiratory system or
mechanical damage to mucous membranes in the esophagus may cause more
hazard than the ingested substance itself)
• if possible, eat about 5 crushed tablets of medicinal charcoal
• seek medical attention
6. First aid in case of contact with substances classified as irritants
6.1. Inhalation
• end exposure immediately, move affected person into the fresh air
• take measures to keep affected person warm
• seek medical attention if irritation, shortness of breath, or other symptoms persist
6.2. Contact with skin
• remove contaminated clothing
• wash affected area with large amounts of water, tepid if possible
• if skin is not injured, soap, soap solution, or shampoo may be used
42
• seek medical attention if skin irritation persists
Note: If the substance adheres to the skin and cannot be removed with water and washing
agent or edible oil (quick-drying glue, for example), do not remove it by force, but have it
done by a specialist.
6.3. Contact with eye
• immediately rinse eye with flowing water, keep eye open (by force if necessary); if
the person has contact lenses, remove them immediately.
• rinse eye for at least 10 minutes
• get medical attention, from a specialist if possible
Note: if the substance adheres to the eyelid and cannot be removed with water, do not
remove it by force; instead seek qualified medical attention.
6.4. Ingestion
• DO NOT INDUCE VOMITING – the inducing vomiting itself may cause
complications (inhalation of substance into lungs and respiratory system, for
example, detergents or other substances producing foam; or mechanical damage
to mucous membranes in the esophagus)
• if possible, eat 1 – 2 crushed tablets of active charcoal
• for persons without symptoms, contact by telephone the Toxicology Information
Centre on whether medical examination is necessary; give the information about
the substance or preparation from the original label or from the safety data sheet of
the substance or preparation
• persons experiencing health problems should seek medical attention.