L#	Date	Time	Lecturer	Topic	Chapter reading
1	17.9.	17:00-19:50			
2	24.9.	17:00-19:50	Pavel Plevka	"Development of X-ray crystallography, crystallization of macromolecules, phase diagram, Crystal symmetry, symmetry operators, point groups, space groups."	"Drenth: 1, 2, 3"
	1.10.			No lecture	
3	8.10.	17:00-19:50	Pavel Plevka	"Diffraction of light by electrons, atoms, unit cell, crystal. Bragg's law. Diffraction images and indexing."	Drenth: 4
4	15.1	17:00-19:50	Pavel Plevka	"Fourier transform, structure factor, intensity of diffraction spots."	"Drenth: 4, 5"
5	22.10.	17:00-19:50	Pavel Plevka	"Solutions to phase problem in X-ray crystallography. Isomorphous replacement, SAD, MAD, Molecular replacement. Rotation and translation function. Model building and refinement."	"Drenth: 7, 10"
6	29.10.	17:00-19:50	Tibor Füzik	"Electron microscope. Interaction of electrons with matter, electron imaging. Amplitude and phase contrast. Contrast transfer function."	"Frank: 1, 2"
7	5.11.	17:00-19:50	Tibor Füzik	"Fourier transform and its properties, convolution, point spread function."	Frank: 2
8	12.11.	17:00-19:50	Jiří Nováček	Analysis of electron micrographs. 2D classification. Principal component analysis.	"Frank: 3, 4"
9	19.11.	17:00-19:50	Jiří Nováček	Three dimensional reconstruction - single particle reconstruction and tomogram calculation. 3D classification.	Frank: 5
10	26.11.	17:00-19:50	Jiří Nováček	"Improving cryo-EM reconstruction, particle polishing, Ewalds, sphere correction, per particle CTF, … Model building and refinement. Detection of errors, validation and detection of mistakes."	Frank: 6
11	3.12.	TBD