The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine Downloaded from nejm.org on November 14, 2023. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.