Interaktivní osnova

Medicinal chemistry - definition and history of the discipline. Nomenclature of medicines.

Physico-chemical properties of drugs with impact on their activity. Quantitative structure-activity relationships.

Structure modification. Homology, analogy, isosteres.

Adrenergic receptor agonists

Structure features with impact on drug action. Spatial arrangement of the molecule and its activity.

Drugs research and development. Drug patents. Approvals of drug preparations. Good laboratory, manufacturing, and clinical practices (GLP, GMP, GCP)

Drug biotransformation (metabolism).

Prodrugs. Weak analgesics, antipyretics and non-steroidal anti-inflammatory drugs (NSAIDs).

Strong analgesics

General a local anesthetics

Antiadrenergics

Muscle relaxants. Antidepressants.

Psychostimulants. Cognitive enhancers and nootropics, halucinogens. Antipsychotics.

Sedatives, hypnotics, anticonvulsants, and antiepileptics, vomitics, and antiemetics. Anxiolytics.