Syllabi identical with topics of lectures:
Date Topic (Name
of the lecturer)
February 18th Medicinal Chemistry: Definition and
history. Drug nomenclature. (Farsa)
February 25th Physico-chemical properties and
biological activity. Structure-Activity- Relationships. Structure optimization. An introduction to Quantitative
Structure-Activity Relationships
(QSAR). (Farsa)
March 4th Structure modifications: homology,
analogy, isomerism, isosterism etc. (Goněc)
March 11th Drugs biotransformation.
Prodrugs. (Farsa)
March 18th Structural features influencing drug action. (Farsa)
March 25th Drugs research and
development. Drug patents. Approvals of drug preparations. Good laboratory,
manufacturing, and clinical practices (GLP, GMP, GCP). (Kroutil)
April 1st Weak analgesics and
non-steroidal anti-inflammatory drugs (NSAIDs). Anti-osteoporotic agents.
(Farsa)
April 8th Strong analgesics -
anodynes. Opioids: morphine, its derivatives, and analogues. Encephalins,
endorphins, opioid receptors antagonists. (Farsa)
April 15th Adrenergic receptor
agonists acting directly and indirectly. Appetite suppressants and other
anti-obesity drugs. (Goněc)
April 22nd Adrenergic receptor
antagonists. (Goněc)
April 29th General and local anaesthetics. Muscle relaxants.
(Farsa)
May 6th CNS agents: antipsychotics, antineurotics.
(Farsa)
May 13th CNS agents: antidepressants, stimulants,
cognitive enhancers, psychotomimetics – hallucinogens. (Farsa)
May 20th CNS agents: sedatives,
hypnotics. Anticonvulsants, antiepileptics. Emetics,
antivomitics, antikinetics. (Farsa)