Syllabi of
practical courses
1. A short reminder of principles of work safety and
fire prevention. Organisation instructions. Sulfacetamide: synthesis, purity
confirmation by TLC, identity confirmation by 1H-NMR.
2. Lidocaine: synthesis, identity and purity
confirmation by melting point, NMR or IR spectroscopy and TLC.
3. Acetylsalicylic acid: synthesis, identity and
purity confirmation by melting point and TLC, purity by HPLC.
4a. Phenytoine: synthesis, identity, and purity
confirmation by melting point and/or NMR spectroscopy. (Alternative:
Methylthiouracil: synthesis, TLC.)
5a. Parabens (methyl-, ethyl-, propyl-, isopropyl- or
isobutylparaben): synthesis, identity and purity confirmation by melting point
and 1H-NMR spectroscopy.
6a. Determination of the acid dissociation constant of
phenytoine (or nitrofurantoin) by means of UV-VIS spectrophotometry. Final
test.
4b.-6b. Valproic acid synthesis. (3 step synthesis,
identity confirmation of every step by 1H-NMR, in step 2
(2,2-dipropylmalonic acid) also by melting point)
7. An eventual substitute course and/or a repeated
final test.
Continuous checking
of study: attendance, observing of laboratory notes at the end of every lesson,
tests are possible and can occur at any time during the semester without any
preliminary warning.
Credit
requirements: 100% attendance, handing-over of reports and prepared compounds
including their characterization data (melting points, chromatograms, NMR
and/or IR interpreted spectra excerpts), at least 60% success in tests.
Teachers: doc.
PharmDr. Oldřich Farsa, Ph.D., RNDr. Eva Havránková, Ph.D.
Laboratory technician: Anna Sedláčková