VLFA07212p Farmakologie I - přednáška

Faculty of Medicine
Autumn 2017
Extent and Intensity
2/0/0. 0 credit(s). Type of Completion: k (colloquium).
Teacher(s)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Jana Unar Vinklerová, Ph.D., MBA (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Renata Bláblová (assistant)
MVDr. Zuzana Babinská, Ph.D. (alternate examiner)
MVDr. Eva Gospošová (alternate examiner)
Mgr. Jana Kubátová, Ph.D. (alternate examiner)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (alternate examiner)
Mgr. Kateřina Nebeská (alternate examiner)
Mgr. Kristýna Nosková, Ph.D. (alternate examiner)
MUDr. Jana Nováková, Ph.D. (alternate examiner)
MUDr. Jana Pistovčáková, Ph.D. (alternate examiner)
Gabriela Přibyl Dovrtělová, Ph.D. (alternate examiner)
doc. PharmDr. Jana Rudá, Ph.D. (alternate examiner)
MUDr. Petra Řiháčková, MBA (alternate examiner)
Mgr. Barbora Říhová, Ph.D. (alternate examiner)
PharmDr. Lenka Součková, Ph.D. (alternate examiner)
Mgr. Tibor Štark, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
VLPF0622p Pathophysiol. II - lect. && VLPA0622c Pathology - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to explain the basic principles of therapy of intoxications
to describe the factors that influence the drug effect
Learning outcomes
Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
is able to suggest therapeutic measures in case of drug intoxication
Syllabus
  • Basic pharmacological terms, definitions. Physiological and pathological factors influencing drug effects. Adverse drug effects.
  • Drug delivery approaches, routes of administration, prolonged release preparations. The management of poisoning.
  • Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration. Basic principles of Pharmacogenetics.
  • Mechanisms of drug action, non-specific, specific. Receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors
  • Pharmacogenetics, pharmacogenomics amd their clinical implications.
  • Drug interactions. Assessment of the seriousness of drug interactions.
  • Pre-clinical and clinical drug development. Drug registration guidance. Regulation and guidelines for "Good Clinical Practice".
  • Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.
  • Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiarities. Specificities of pharmacotherapy in the elderly.
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    not specified
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
Teaching methods
lectures, presentations by professionals in the sectors
Assessment methods
Colloquium - ROPOT test
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (Autumn 2017, recent)
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