C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2025
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
In-person direct teaching
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination. It consists of a simple calculation of a density matrix evolution and of a discussion of one of the topics of the course. Students may use their notes and the textbook.
Language of instruction
English
Follow-Up Courses
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2024
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Mon 19. 2. to Sun 26. 5. Tue 9:00–10:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
English
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2023
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 11:00–12:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
English
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2022
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 9:00–10:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
English
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2021
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Mon 1. 3. to Fri 14. 5. Tue 8:00–9:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
English
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2020
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 9:00–10:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
English
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2018
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Petr Louša, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Mon 17. 9. to Fri 14. 12. Tue 9:00–10:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
autumn 2017
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Petr Louša, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Mon 18. 9. to Fri 15. 12. Tue 9:00–10:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
Syllabus
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017, xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2016
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Petr Louša, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Mon 19. 9. to Sun 18. 12. Mon 8:00–9:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Classical description, vector model (VS 1--46, [pp. of V. Sklenář's presentation in IS], JK 4, [chapters of J. Keeler's book in IS])
  • 2. Quantum mechanics basics (Keeler 2010)
  • 3. Product operator formalism (VS 92--118, JK 6)
  • 4. Interactions, energy levels, nuclear Overhaus effect (VS 9--23, 154--168, JK 2, 8.4)
  • 5. Relaxation (JK 8)
  • 6. 1D Fourier spektroscopy, spin echoes, INEPT (VS 119--139, JK 3, 6)
  • 7. Principle of 2D spektroskopy, NOESY, EXSY (VS 140--153, JK 7)
  • 8. Coherence transfer, COSY (VS 169--183, JK 7)
  • 9. Heteronuclear correlation, HSQC, decoupling, TOCSY (VS 184--192, JK 7)
  • 10. Frekvency discrimination, phase cycles, gradients (VS 193--209, JK 7, 9)
  • 11. Signal processing (VS 47--76, JK 4)
  • 12. NMR spectrometer (VS 77--91, JK 5)
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2015
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Petr Louša, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 15:00–16:50 C04/211, Wed 17:00–17:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Classical description, vector model (VS 1--46, [pp. of V. Sklenář's presentation in IS], JK 4, [chapters of J. Keeler's book in IS])
  • 2. Quantum mechanics basics (Keeler 2010)
  • 3. Product operator formalism (VS 92--118, JK 6)
  • 4. Interactions, energy levels, nuclear Overhaus effect (VS 9--23, 154--168, JK 2, 8.4)
  • 5. Relaxation (JK 8)
  • 6. 1D Fourier spektroscopy, spin echoes, INEPT (VS 119--139, JK 3, 6)
  • 7. Principle of 2D spektroskopy, NOESY, EXSY (VS 140--153, JK 7)
  • 8. Coherence transfer, COSY (VS 169--183, JK 7)
  • 9. Heteronuclear correlation, HSQC, decoupling, TOCSY (VS 184--192, JK 7)
  • 10. Frekvency discrimination, phase cycles, gradients (VS 193--209, JK 7, 9)
  • 11. Signal processing (VS 47--76, JK 4)
  • 12. NMR spectrometer (VS 77--91, JK 5)
Literature
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Chichester, England: John Wiley & Sons, 2008, xxv, 714. ISBN 9780470511176. info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007, xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
    not specified
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2014
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Srb, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 15:00–16:50 C05/114, Wed 17:00–17:50 C05/114
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipole, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin-spin relaxation, Fourier transform, sensitivity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representation, operators, spin Hamiltonian in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltonian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxation times, polarization transfer, INEPT, DEPT, composite pulses, homo- and heteronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipole-dipole correlation - NOESY, phase cycles, methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR applications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2013
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Srb, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 13:00–14:50 C04/211, Tue 15:00–15:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipole, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin-spin relaxation, Fourier transform, sensitivity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representation, operators, spin Hamiltonian in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltonian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxation times, polarization transfer, INEPT, DEPT, composite pulses, homo- and heteronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipole-dipole correlation - NOESY, phase cycles, methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR applications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2012
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Vojtěch Kubáň, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 13:00–15:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2011
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Vojtěch Kubáň, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 14:00–15:50 C04/211, Fri 10:00–10:50 C04/211
  • Timetable of Seminar Groups:
C5320/01: No timetable has been entered into IS. V. Kubáň
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2010
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Tue 10:00–11:50 C04/211
  • Timetable of Seminar Groups:
C5320/C5320_01: No timetable has been entered into IS.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2009
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 10:00–11:50 C04/211
  • Timetable of Seminar Groups:
C5320/01: No timetable has been entered into IS. P. Kadeřávek
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2008
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 11:00–12:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2007
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Wed 14:00–15:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 23 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2006
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Timetable
Thu 10:00–11:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Language of instruction
Czech
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2005
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Timetable
Wed 13:00–14:50 02004
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • NMR of macromolecules : a practical approach. Edited by Gordon C.K. Roberts. Oxford: Oxford University Press, 1993, 399 s. ISBN 0-19-963224-3. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • SCHRAML, Jan. Dvourozměrná NMR spektroskopie. 1. vyd. Praha: Academia, 1987, 130 s. info
  • GOLJER, Igor and Tibor LIPTAJ. Nové metódy FT NMR spektroskopie kvapalín. 1. vyd. Bratislava: VEDA vydavatel'stvo Slovenskej akadémie vied, 1986, 181 s. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Language of instruction
Czech
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2004
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Timetable
Wed 11:00–12:50 03021
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus (in Czech)
  • 1. Úvod: Historie NMR spektroskopie a současné trendy - využití NMR to ke studiu molekulární struktury v kapalné a pevné fázi, NMR tomografie a NMR zobrazování, pohledy do budoucna, prohlídka NMR laboratoře PřF MU. 2. Základní principy: magnetický dipól, rezonanční podmínka, NMR spektrometr, Fourierova spektroskopie, klasický popis - Blochovy rovnice, relaxační procesy - spin-mřížková a spin-spinová relaxace, Fourierova transformace, citlivost měření. 3. Dynamika spinových systémů: základní vlastnosti nukleárního spinového systému, teorie matic hustoty, maticové representace, operátory, spinový Hamiltonián v Hilbertově representaci, teorie průměrného Hamiltoniánu. 4. Součinový operátorový formalismus: základní principy, názvosloví, vývoj součinových operátorů, Hamiltonián v součinové bázi, složené rotace, pozorovatelné veličiny. 5. 1D Fourierova spektroskopie: excitační sekvence, principy spinového echa, měření relaxačních časů, přenos polarizace, metody INEPT a DEPT, složené pulzy, homo- a hetero-nukleární decoupling, pulzní gradienty 6. 2D Fourierova spektroskopie: základní principy a formální teorie detekce NMR ve dvou frekvenčních dimenzích, koherenční stezky. 7. Základní metody 2D spektroskopie: korelace chemických posunů - COSY, J-rozlišená spektroskopie, měření spin-spinových skalárních interakcí, korelace dipól-dipólových interakcí - NOESY spektroskopie, fázové cykly, varianty pro měření homo- a hetero-nukleárních spinových systémů, editace spekter. 8. Aplikace NMR ve strukturní analýze biomolekul: proteiny a peptidy, nukleové kyseliny, získávání strukturních parametrů: měření vzdáleností vodíkových atomů, určování dihedrálních úhlů, matematická rekonstrukce prostorové struktury makromolekul.
Language of instruction
Czech
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2003
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus (in Czech)
  • 1. Úvod: Historie NMR spektroskopie a současné trendy - využití NMR to ke studiu molekulární struktury v kapalné a pevné fázi, NMR tomografie a NMR zobrazování, pohledy do budoucna, prohlídka NMR laboratoře PřF MU. 2. Základní principy: magnetický dipól, rezonanční podmínka, NMR spektrometr, Fourierova spektroskopie, klasický popis - Blochovy rovnice, relaxační procesy - spin-mřížková a spin-spinová relaxace, Fourierova transformace, citlivost měření. 3. Dynamika spinových systémů: základní vlastnosti nukleárního spinového systému, teorie matic hustoty, maticové representace, operátory, spinový Hamiltonián v Hilbertově representaci, teorie průměrného Hamiltoniánu. 4. Součinový operátorový formalismus: základní principy, názvosloví, vývoj součinových operátorů, Hamiltonián v součinové bázi, složené rotace, pozorovatelné veličiny. 5. 1D Fourierova spektroskopie: excitační sekvence, principy spinového echa, měření relaxačních časů, přenos polarizace, metody INEPT a DEPT, složené pulzy, homo- a hetero-nukleární decoupling, pulzní gradienty 6. 2D Fourierova spektroskopie: základní principy a formální teorie detekce NMR ve dvou frekvenčních dimenzích, koherenční stezky. 7. Základní metody 2D spektroskopie: korelace chemických posunů - COSY, J-rozlišená spektroskopie, měření spin-spinových skalárních interakcí, korelace dipól-dipólových interakcí - NOESY spektroskopie, fázové cykly, varianty pro měření homo- a hetero-nukleárních spinových systémů, editace spekter. 8. Aplikace NMR ve strukturní analýze biomolekul: proteiny a peptidy, nukleové kyseliny, získávání strukturních parametrů: měření vzdáleností vodíkových atomů, určování dihedrálních úhlů, matematická rekonstrukce prostorové struktury makromolekul.
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2002
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus (in Czech)
  • 1. Úvod: Historie NMR spektroskopie a současné trendy - využití NMR to ke studiu molekulární struktury v kapalné a pevné fázi, NMR tomografie a NMR zobrazování, pohledy do budoucna, prohlídka NMR laboratoře PřF MU. 2. Základní principy: magnetický dipól, rezonanční podmínka, NMR spektrometr, Fourierova spektroskopie, klasický popis - Blochovy rovnice, relaxační procesy - spin-mřížková a spin-spinová relaxace, Fourierova transformace, citlivost měření. 3. Dynamika spinových systémů: základní vlastnosti nukleárního spinového systému, teorie matic hustoty, maticové representace, operátory, spinový Hamiltonián v Hilbertově representaci, teorie průměrného Hamiltoniánu. 4. Součinový operátorový formalismus: základní principy, názvosloví, vývoj součinových operátorů, Hamiltonián v součinové bázi, složené rotace, pozorovatelné veličiny. 5. 1D Fourierova spektroskopie: excitační sekvence, principy spinového echa, měření relaxačních časů, přenos polarizace, metody INEPT a DEPT, složené pulzy, homo- a hetero-nukleární decoupling, pulzní gradienty 6. 2D Fourierova spektroskopie: základní principy a formální teorie detekce NMR ve dvou frekvenčních dimenzích, koherenční stezky. 7. Základní metody 2D spektroskopie: korelace chemických posunů - COSY, J-rozlišená spektroskopie, měření spin-spinových skalárních interakcí, korelace dipól-dipólových interakcí - NOESY spektroskopie, fázové cykly, varianty pro měření homo- a hetero-nukleárních spinových systémů, editace spekter. 8. Aplikace NMR ve strukturní analýze biomolekul: proteiny a peptidy, nukleové kyseliny, získávání strukturních parametrů: měření vzdáleností vodíkových atomů, určování dihedrálních úhlů, matematická rekonstrukce prostorové struktury makromolekul.
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2001
Extent and Intensity
2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus (in Czech)
  • 1. Úvod: Historie NMR spektroskopie a současné trendy - využití NMR to ke studiu molekulární struktury v kapalné a pevné fázi, NMR tomografie a NMR zobrazování, pohledy do budoucna, prohlídka NMR laboratoře PřF MU. 2. Základní principy: magnetický dipól, rezonanční podmínka, NMR spektrometr, Fourierova spektroskopie, klasický popis - Blochovy rovnice, relaxační procesy - spin-mřížková a spin-spinová relaxace, Fourierova transformace, citlivost měření. 3. Dynamika spinových systémů: základní vlastnosti nukleárního spinového systému, teorie matic hustoty, maticové representace, operátory, spinový Hamiltonián v Hilbertově representaci, teorie průměrného Hamiltoniánu. 4. Součinový operátorový formalismus: základní principy, názvosloví, vývoj součinových operátorů, Hamiltonián v součinové bázi, složené rotace, pozorovatelné veličiny. 5. 1D Fourierova spektroskopie: excitační sekvence, principy spinového echa, měření relaxačních časů, přenos polarizace, metody INEPT a DEPT, složené pulzy, homo- a hetero-nukleární decoupling, pulzní gradienty 6. 2D Fourierova spektroskopie: základní principy a formální teorie detekce NMR ve dvou frekvenčních dimenzích, koherenční stezky. 7. Základní metody 2D spektroskopie: korelace chemických posunů - COSY, J-rozlišená spektroskopie, měření spin-spinových skalárních interakcí, korelace dipól-dipólových interakcí - NOESY spektroskopie, fázové cykly, varianty pro měření homo- a hetero-nukleárních spinových systémů, editace spekter. 8. Aplikace NMR ve strukturní analýze biomolekul: proteiny a peptidy, nukleové kyseliny, získávání strukturních parametrů: měření vzdáleností vodíkových atomů, určování dihedrálních úhlů, matematická rekonstrukce prostorové struktury makromolekul.
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2000
Extent and Intensity
2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 1999
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 16 fields of study the course is directly associated with, display
Syllabus
  • Introduction to basic principles of NMR spectroscopy. Theoretical concepts of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2011 - acreditation

The information about the term Autumn 2011 - acreditation is not made public

Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2010 - only for the accreditation
Extent and Intensity
2/1/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
doc. RNDr. Radovan Fiala, CSc. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. At the end of the course students should understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005, xv, 459. ISBN 0470017872. info
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Teaching methods
Lectures and seminars
Assessment methods
Oral examination
Language of instruction
Czech
Follow-Up Courses
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.

C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Autumn 2007 - for the purpose of the accreditation
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Vladimír Sklenář, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
Syllabus
  • 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
Literature
  • HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. 1st pub. Oxford: Oxford University Press, 2000, 85 s. ISBN 0198504152. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996, xi, 196. ISBN 0471039004. info
  • Protein NMR spectroscopy principles and practice. San Diego: Academic Press, 1996, 587 s. ISBN 0121644901. info
  • CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996, 587 pp. ISBN 0-12-164490-1. info
  • EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Oxford: Oxford University Press, 1995, xvi, 444 s. ISBN 0-19-854766-8. info
  • VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. New York: VCH Publishers, 1995, 399 s. ISBN 1-56081-665-1. info
  • Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994, xxii, 958. ISBN 1-56081-664-3. info
  • SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. 2nd ed. Oxford: Oxford University Press, 1993, 127 s. ISBN 0198558120. info
  • RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
  • NMR and the periodic table. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978, 459 s. ISBN 0123276500. info
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (recent)