Course Information

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2024

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
In-person direct teaching

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Wed 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Main objectives can be summarized as follows:
to discuss basic principles of organic stereochemistry with preference to to a symmetry-based approach to structures, ligands, faces and reaction classification;
to understand chirality as a condition sine qua non for enantiomerism and enantiodifferentiation;
to discuss the time-dimension in connection with intramolecular dynamism and time-scale of instrumental methods;
to point out problems of the origin of homochirality in living systems;
to learn about topological stereochemistry.

Learning outcomes

Student will understand concept of isomerism of chemical compounds;
will be able to work with concepts conformation, configuration, chirality and optical activity;
will be able to chose suitable methods for identification of stereoisomers, determination of their contents in mixtures, and their possible separation;
utilize symmetry for elucidation of heterotopicity of homomorphic ligands and faces;
recognize stereoselective reactions and explain reasons of their selectivity based on steric, stereoelectronic and further effects;
utilize basic chiroptic methods for analysis and identification of chiral compounds.

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2023

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Learning outcomes

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2022

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Wed 17:00–18:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Learning outcomes

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

C5500 Stereochemistry of Organic Compounds

Faculty of Science
autumn 2021

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Wed 9:00–10:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Learning outcomes

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2020

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 15:00–16:50 prace doma

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Learning outcomes

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2019

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 15 fields of study the course is directly associated with, display

Course objectives

Learning outcomes

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

recommended literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info

not specified

WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2018

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Mon 17. 9. to Fri 14. 12. Wed 12:00–13:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
autumn 2017

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Mon 18. 9. to Fri 15. 12. Wed 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

English

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2016

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Mon 19. 9. to Sun 18. 12. Wed 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2015

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 15:00–16:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2014

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Wed 14:00–15:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2013

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 14:00–15:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2012

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 9:00–10:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2011

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 9:00–10:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2010

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Fri 10:00–11:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2009

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Wed 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2008

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 13:00–14:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Assessment methods

Lecture;
oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2007

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Tue 16:00–17:50 A08/309

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Basic principles of organic stereochemistry will be highlighted and discussed. Preference will be given to a symmetry-based approach to structures, ligands, faces and reactions classification. Chirality will be discussed as a condition sine qua non for enantiomerism and enantiodifferentiation. The time-dimension will be thoroughly discussed in connection with intramolecular dynamism and time-scale of instrumental methods. Problems of the origin of homochirality in living systems will be pointed out and topological stereochemistry will be mentioned.

Syllabus (in Czech)

1. Struktura. Význam, způsoby popisu struktury, vnitřní souřadnice. Konstituce, konfigurace a konformace. Způsoby určování struktury. 2. Stereoisomerie. Hlavní typy stereoisomerů. Energetické vymezení stereoisomerů. Residuální stereoisomery. Diastereomery a enantiomery. 3. Úvod do symetrie. Prvky symetrie, operátory symetrie a bodové grupy symetrie. Vztah chirality a symetrie. Vztah symetrie a molekulárních vlastností. Stáčení roviny polarizovaného světla, dipólový moment. 4. Konfigurace. Definice absolutní a relativní konfigurace. Nomenklaturní vyjádření absolutní a relativní konfigurace. Metody určování absolutní a relativní konfigurace. 5. Vlastnosti stereoisomerů. Rozlišení stereoisomerů. Vlastnosti racemátů a jejich enentiomerních složek. Metody určování enantiomerního a diastereomerního složení, časová škála experimentu (chiroptické metody, NMR, chromatografie a pod.). 6. Separace stereoisomerů. Separace enantiomerů krystalizací, chemickými metodami přes diastereomery. Kinetická resoluce. Racemizace. 7. Homotopické a heterotopické ligandy a strany, prostereoisomerie a prochiralita. Enantiotopicita, diastereotopicita. Heterotopicita a NMR, anisochronie a anisogamie. 8. Stereochemie alkenů. Alkeny s nízkými rotačními barierami, neplanární alkeny. Dvojné vazby C=N a N=N. Určování konfigurace isomerů chemickými a fyzikálními metodami. Metody interkonverze cis- trans isomerů. 9. Konformace nasycených a nenasycených acyklických sloučenin. Nasycené acyklické molekuly s polárními substituenty - anomerní efekt. Diastereomerní rovnováhy v acyklických systémech. Fyzikální a spektrální vlastnosti diastereomerů a konformerů. Konformace a reaktivita. Winsteinova-Holnesova rovnice a Curtiův-Hammettův princip. 10. Konformace a konfigurace cyklických molekul. Určování konfigurace substituovaných kruhů. Stabilita cyklických molekul. Pnutí kruhu, snadnost cyklizace v závislosti na velikosti kruhu a povaze reakčních center, Baldwinova pravidla. Konformační aspekty chemie monocyklických a polycyklických sloučenin, stereoelektronické efekty. 11. Stereoselektivní syntéza. Základy terminologie, kategorie stereoslektivní syntézy. Strategie řízení stereochemie v diastereoselektivní a enantioselektivní syntéze. Využití chirálních neracemických reagentů a katalyzátorů. 12. Chiroptické vlastnosti. Optická aktivita. Anisotropní refrakce, Optická rotační disperse (ORD). Anisotropní absorpce, Cirkulární dichroismus (CD). Využití CD a ORD při určování konfigurace a konformace. Polarimetrie, empirická pravidla a korelace. 13. Chiralita molekul bez center chirality. Nomenklatura. Alleny, spirany, atropoisomerie způsobená zábranou rotace kolem jednoduché vazby. Heliceny. Planární chiralita (Cyklofány, anuleny, metaloceny a d.). Kryptostereoisomerie.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2006

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Timetable

Thu 16:00–17:50 03021

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus (in Czech)

1. Struktura. Význam, způsoby popisu struktury, vnitřní souřadnice. Konstituce, konfigurace a konformace. Způsoby určování struktury. 2. Stereoisomerie. Hlavní typy stereoisomerů. Energetické vymezení stereoisomerů. Residuální stereoisomery. Diastereomery a enantiomery. 3. Úvod do symetrie. Prvky symetrie, operátory symetrie a bodové grupy symetrie. Vztah chirality a symetrie. Vztah symetrie a molekulárních vlastností. Stáčení roviny polarizovaného světla, dipólový moment. 4. Konfigurace. Definice absolutní a relativní konfigurace. Nomenklaturní vyjádření absolutní a relativní konfigurace. Metody určování absolutní a relativní konfigurace. 5. Vlastnosti stereoisomerů. Rozlišení stereoisomerů. Vlastnosti racemátů a jejich enentiomerních složek. Metody určování enantiomerního a diastereomerního složení, časová škála experimentu (chiroptické metody, NMR, chromatografie a pod.). 6. Separace stereoisomerů. Separace enantiomerů krystalizací, chemickými metodami přes diastereomery. Kinetická resoluce. Racemizace. 7. Homotopické a heterotopické ligandy a strany, prostereoisomerie a prochiralita. Enantiotopicita, diastereotopicita. Heterotopicita a NMR, anisochronie a anisogamie. 8. Stereochemie alkenů. Alkeny s nízkými rotačními barierami, neplanární alkeny. Dvojné vazby C=N a N=N. Určování konfigurace isomerů chemickými a fyzikálními metodami. Metody interkonverze cis- trans isomerů. 9. Konformace nasycených a nenasycených acyklických sloučenin. Nasycené acyklické molekuly s polárními substituenty - anomerní efekt. Diastereomerní rovnováhy v acyklických systémech. Fyzikální a spektrální vlastnosti diastereomerů a konformerů. Konformace a reaktivita. Winsteinova-Holnesova rovnice a Curtiův-Hammettův princip. 10. Konformace a konfigurace cyklických molekul. Určování konfigurace substituovaných kruhů. Stabilita cyklických molekul. Pnutí kruhu, snadnost cyklizace v závislosti na velikosti kruhu a povaze reakčních center, Baldwinova pravidla. Konformační aspekty chemie monocyklických a polycyklických sloučenin, stereoelektronické efekty. 11. Stereoselektivní syntéza. Základy terminologie, kategorie stereoslektivní syntézy. Strategie řízení stereochemie v diastereoselektivní a enantioselektivní syntéze. Využití chirálních neracemických reagentů a katalyzátorů. 12. Chiroptické vlastnosti. Optická aktivita. Anisotropní refrakce, Optická rotační disperse (ORD). Anisotropní absorpce, Cirkulární dichroismus (CD). Využití CD a ORD při určování konfigurace a konformace. Polarimetrie, empirická pravidla a korelace. 13. Chiralita molekul bez center chirality. Nomenklatura. Alleny, spirany, atropoisomerie způsobená zábranou rotace kolem jednoduché vazby. Heliceny. Planární chiralita (Cyklofány, anuleny, metaloceny a d.). Kryptostereoisomerie.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2005

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus (in Czech)

1. Struktura. Význam, způsoby popisu struktury, vnitřní souřadnice. Konstituce, konfigurace a konformace. Způsoby určování struktury. 2. Stereoisomerie. Hlavní typy stereoisomerů. Energetické vymezení stereoisomerů. Residuální stereoisomery. Diastereomery a enantiomery. 3. Úvod do symetrie. Prvky symetrie, operátory symetrie a bodové grupy symetrie. Vztah chirality a symetrie. Vztah symetrie a molekulárních vlastností. Stáčení roviny polarizovaného světla, dipólový moment. 4. Konfigurace. Definice absolutní a relativní konfigurace. Nomenklaturní vyjádření absolutní a relativní konfigurace. Metody určování absolutní a relativní konfigurace. 5. Vlastnosti stereoisomerů. Rozlišení stereoisomerů. Vlastnosti racemátů a jejich enentiomerních složek. Metody určování enantiomerního a diastereomerního složení, časová škála experimentu (chiroptické metody, NMR, chromatografie a pod.). 6. Separace stereoisomerů. Separace enantiomerů krystalizací, chemickými metodami přes diastereomery. Kinetická resoluce. Racemizace. 7. Homotopické a heterotopické ligandy a strany, prostereoisomerie a prochiralita. Enantiotopicita, diastereotopicita. Heterotopicita a NMR, anisochronie a anisogamie. 8. Stereochemie alkenů. Alkeny s nízkými rotačními barierami, neplanární alkeny. Dvojné vazby C=N a N=N. Určování konfigurace isomerů chemickými a fyzikálními metodami. Metody interkonverze cis- trans isomerů. 9. Konformace nasycených a nenasycených acyklických sloučenin. Nasycené acyklické molekuly s polárními substituenty - anomerní efekt. Diastereomerní rovnováhy v acyklických systémech. Fyzikální a spektrální vlastnosti diastereomerů a konformerů. Konformace a reaktivita. Winsteinova-Holnesova rovnice a Curtiův-Hammettův princip. 10. Konformace a konfigurace cyklických molekul. Určování konfigurace substituovaných kruhů. Stabilita cyklických molekul. Pnutí kruhu, snadnost cyklizace v závislosti na velikosti kruhu a povaze reakčních center, Baldwinova pravidla. Konformační aspekty chemie monocyklických a polycyklických sloučenin, stereoelektronické efekty. 11. Stereoselektivní syntéza. Základy terminologie, kategorie stereoslektivní syntézy. Strategie řízení stereochemie v diastereoselektivní a enantioselektivní syntéze. Využití chirálních neracemických reagentů a katalyzátorů. 12. Chiroptické vlastnosti. Optická aktivita. Anisotropní refrakce, Optická rotační disperse (ORD). Anisotropní absorpce, Cirkulární dichroismus (CD). Využití CD a ORD při určování konfigurace a konformace. Polarimetrie, empirická pravidla a korelace. 13. Chiralita molekul bez center chirality. Nomenklatura. Alleny, spirany, atropoisomerie způsobená zábranou rotace kolem jednoduché vazby. Heliceny. Planární chiralita (Cyklofány, anuleny, metaloceny a d.). Kryptostereoisomerie.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Spring 2005

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus (in Czech)

1. Struktura. Význam, způsoby popisu struktury, vnitřní souřadnice. Konstituce, konfigurace a konformace. Způsoby určování struktury. 2. Stereoisomerie. Hlavní typy stereoisomerů. Energetické vymezení stereoisomerů. Residuální stereoisomery. Diastereomery a enantiomery. 3. Úvod do symetrie. Prvky symetrie, operátory symetrie a bodové grupy symetrie. Vztah chirality a symetrie. Vztah symetrie a molekulárních vlastností. Stáčení roviny polarizovaného světla, dipólový moment. 4. Konfigurace. Definice absolutní a relativní konfigurace. Nomenklaturní vyjádření absolutní a relativní konfigurace. Metody určování absolutní a relativní konfigurace. 5. Vlastnosti stereoisomerů. Rozlišení stereoisomerů. Vlastnosti racemátů a jejich enentiomerních složek. Metody určování enantiomerního a diastereomerního složení, časová škála experimentu (chiroptické metody, NMR, chromatografie a pod.). 6. Separace stereoisomerů. Separace enantiomerů krystalizací, chemickými metodami přes diastereomery. Kinetická resoluce. Racemizace. 7. Homotopické a heterotopické ligandy a strany, prostereoisomerie a prochiralita. Enantiotopicita, diastereotopicita. Heterotopicita a NMR, anisochronie a anisogamie. 8. Stereochemie alkenů. Alkeny s nízkými rotačními barierami, neplanární alkeny. Dvojné vazby C=N a N=N. Určování konfigurace isomerů chemickými a fyzikálními metodami. Metody interkonverze cis- trans isomerů. 9. Konformace nasycených a nenasycených acyklických sloučenin. Nasycené acyklické molekuly s polárními substituenty - anomerní efekt. Diastereomerní rovnováhy v acyklických systémech. Fyzikální a spektrální vlastnosti diastereomerů a konformerů. Konformace a reaktivita. Winsteinova-Holnesova rovnice a Curtiův-Hammettův princip. 10. Konformace a konfigurace cyklických molekul. Určování konfigurace substituovaných kruhů. Stabilita cyklických molekul. Pnutí kruhu, snadnost cyklizace v závislosti na velikosti kruhu a povaze reakčních center, Baldwinova pravidla. Konformační aspekty chemie monocyklických a polycyklických sloučenin, stereoelektronické efekty. 11. Stereoselektivní syntéza. Základy terminologie, kategorie stereoslektivní syntézy. Strategie řízení stereochemie v diastereoselektivní a enantioselektivní syntéze. Využití chirálních neracemických reagentů a katalyzátorů. 12. Chiroptické vlastnosti. Optická aktivita. Anisotropní refrakce, Optická rotační disperse (ORD). Anisotropní absorpce, Cirkulární dichroismus (CD). Využití CD a ORD při určování konfigurace a konformace. Polarimetrie, empirická pravidla a korelace. 13. Chiralita molekul bez center chirality. Nomenklatura. Alleny, spirany, atropoisomerie způsobená zábranou rotace kolem jednoduché vazby. Heliceny. Planární chiralita (Cyklofány, anuleny, metaloceny a d.). Kryptostereoisomerie.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Spring 2004

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods. 2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers. 3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment). 4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration. 5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition. 6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization. 7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony. 8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers. 9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle. 10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect. 11. Stereoselective synthesis. 12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation. 13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2002

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Jaroslav Jonas, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Prerequisites

Organic Chemistry I and II Physical Chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Course objectives

Syllabus

1.Pasteur and vant Hoff - two different ways to stereoochemistry. Symmetry-based and constitution-based approaches. Topological stereochemistry. 2. Inner coordinates of molecular structure, their changes through intramolecular dynamics and the corresponding energy landscape. Configuration and conformation. 3. Symmetry, asymmetry, dissymetry, and chirality. Molecular and local symmetry and point group classification thereof. 4. Local symmetry and stereogenicity. Prochirality and prostereogenicity. Symmetry of a dynamic molecular structure in relation to experimental time scale. 5. Isomerism and topicity with static molecular structures. Classification and methods of analysis. 6. Isomerism and topicity with dynamic molecular structures. Time scale of spectroscopic methods - especially NMR. 7. Absolute and relative configuration - methods for determination. 8. Racemic modifications, their separation into enantiomers. 9. Stereisomerism of acyclic and cyclic systems due to rotation around single bonds. 10. Stereoelectronic effects, especially the anomeric effect. 11. Stereoisomerism due to multiple bonds. 12.Stereodifferentiating reactions - classification and general considerations. 13. Stereodifferentiating reactions exemplified. 14. Stereochemistry of penta- and hexacoordinated compounds as compared to tetra-coordination. Stereochemical methodology - an overview.

Literature

Eliel E. L., Wilen S.H., Doyle M.P.: Basic Organic Stereochemistry, Wiley 2001, 704 pp., ISBN 0-471-37499-7
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Assessment methods (in Czech)

A lecture interspersed with seminar - oral examination.

Language of instruction

English

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2001

Extent and Intensity

2/0/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Jaroslav Jonas, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Prerequisites

Organic Chemistry I and II Physical Chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Course objectives

Syllabus

1.Pasteur and vant Hoff - two different ways to stereoochemistry. Symmetry-based and constitution-based approaches. Topological stereochemistry. 2. Inner coordinates of molecular structure, their changes through intramolecular dynamics and the corresponding energy landscape. Configuration and conformation. 3. Symmetry, asymmetry, dissymetry, and chirality. Molecular and local symmetry and point group classification thereof. 4. Local symmetry and stereogenicity. Prochirality and prostereogenicity. Symmetry of a dynamic molecular structure in relation to experimental time scale. 5. Isomerism and topicity with static molecular structures. Classification and methods of analysis. 6. Isomerism and topicity with dynamic molecular structures. Time scale of spectroscopic methods - especially NMR. 7. Absolute and relative configuration - methods for determination. 8. Racemic modifications, their separation into enantiomers. 9. Stereisomerism of acyclic and cyclic systems due to rotation around single bonds. 10. Stereoelectronic effects, especially the anomeric effect. 11. Stereoisomerism due to multiple bonds. 12.Stereodifferentiating reactions - classification and general considerations. 13. Stereodifferentiating reactions exemplified. 14. Stereochemistry of penta- and hexacoordinated compounds as compared to tetra-coordination. Stereochemical methodology - an overview.

Literature

Eliel E. L., Wilen S.H., Doyle M.P.: Basic Organic Stereochemistry, Wiley 2001, 704 pp., ISBN 0-471-37499-7
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Assessment methods (in Czech)

A lecture interspersed with seminar - oral examination.

Language of instruction

English

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2000

Extent and Intensity

2/0/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Jaroslav Jonas, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Chemistry Section – Faculty of Science

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Language of instruction

English

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2011 - acreditation

The information about the term Autumn 2011 - acreditation is not made public

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2010 - only for the accreditation

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus

1. Structure. Meaning, description of structure, constitution, configuration and conformation. Structure determination methods.
2. Stereoisomers. Diastereomers and enantiomers. Energy barriers and residual stereoisomers.
3. Symmetry. Symmetry elements and operators, symmetry point groups. Chirality and symmetry. Symmetry and molecular properties (rotation of polarized light, dipole moment).
4. Configuration. Relative and absolute configuration. Notation. Determination of absolute and relative configuration.
5. Stereoisomers discrimination. Properties of racemates and their enantiomer components. Determination of enantiomer and diastreomer composition.
6. Separation of stereoisomers, resolution. Crystallization, chromatography, chemical separation methods via diastereomers. Kinetic resolution. Racemization.
7. Homotopic and heterotopic ligands and faces. Prostereoisomerism and prochirality. Enantiotopicity and diastereotopicity. Heterotopicity and NMR, anisochrony.
8. Stereochemistry of molecules with double bond. Alkenes. The C=N and N=N double bonds. Determination of isomer configuration, chemical and physical methods. Interconversion of isomers.
9. Conformation of acyclic saturated and unsaturated compounds. Generalized anomeric effect. Conformation and physical and spectral properties of molecules and their reactivity. Winstein-Holness equation. Curtin-Hammett principle.
10. Conformation and configuration of cyclic molecules. Determination of configuration of substituted rings. Stability of cyclic molecules. Baldwin rules. Conformational aspects of chemistry of some ring compounds (six- and five-membered rings). Anomeric effect.
11. Stereoselective synthesis.
12. Chiroptical properties. Optical rotatory dispersion (Cotton effect). Circular dichroism. Application of chiroptical methods to determination of configuration and conformation.
13. Chirality of molecules devoid of chiral centers. Axial and planar chirality. Nomenclature. Allenes, Spiranes and others. Atropoisomerism, biphenyls and others. Helicenes. Cyclophanes and other molecules with planar chirality.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Teaching methods

Lectures

Assessment methods

Oral exam follows a written test.

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

C5500 Stereochemistry of Organic Compounds

Faculty of Science
Autumn 2007 - for the purpose of the accreditation

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

doc. RNDr. Ctibor Mazal, CSc. (lecturer)

Guaranteed by

prof. RNDr. Jaroslav Jonas, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science

Prerequisites

Organic chemistry I and II

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

Syllabus (in Czech)

1. Struktura. Význam, způsoby popisu struktury, vnitřní souřadnice. Konstituce, konfigurace a konformace. Způsoby určování struktury. 2. Stereoisomerie. Hlavní typy stereoisomerů. Energetické vymezení stereoisomerů. Residuální stereoisomery. Diastereomery a enantiomery. 3. Úvod do symetrie. Prvky symetrie, operátory symetrie a bodové grupy symetrie. Vztah chirality a symetrie. Vztah symetrie a molekulárních vlastností. Stáčení roviny polarizovaného světla, dipólový moment. 4. Konfigurace. Definice absolutní a relativní konfigurace. Nomenklaturní vyjádření absolutní a relativní konfigurace. Metody určování absolutní a relativní konfigurace. 5. Vlastnosti stereoisomerů. Rozlišení stereoisomerů. Vlastnosti racemátů a jejich enentiomerních složek. Metody určování enantiomerního a diastereomerního složení, časová škála experimentu (chiroptické metody, NMR, chromatografie a pod.). 6. Separace stereoisomerů. Separace enantiomerů krystalizací, chemickými metodami přes diastereomery. Kinetická resoluce. Racemizace. 7. Homotopické a heterotopické ligandy a strany, prostereoisomerie a prochiralita. Enantiotopicita, diastereotopicita. Heterotopicita a NMR, anisochronie a anisogamie. 8. Stereochemie alkenů. Alkeny s nízkými rotačními barierami, neplanární alkeny. Dvojné vazby C=N a N=N. Určování konfigurace isomerů chemickými a fyzikálními metodami. Metody interkonverze cis- trans isomerů. 9. Konformace nasycených a nenasycených acyklických sloučenin. Nasycené acyklické molekuly s polárními substituenty - anomerní efekt. Diastereomerní rovnováhy v acyklických systémech. Fyzikální a spektrální vlastnosti diastereomerů a konformerů. Konformace a reaktivita. Winsteinova-Holnesova rovnice a Curtiův-Hammettův princip. 10. Konformace a konfigurace cyklických molekul. Určování konfigurace substituovaných kruhů. Stabilita cyklických molekul. Pnutí kruhu, snadnost cyklizace v závislosti na velikosti kruhu a povaze reakčních center, Baldwinova pravidla. Konformační aspekty chemie monocyklických a polycyklických sloučenin, stereoelektronické efekty. 11. Stereoselektivní syntéza. Základy terminologie, kategorie stereoslektivní syntézy. Strategie řízení stereochemie v diastereoselektivní a enantioselektivní syntéze. Využití chirálních neracemických reagentů a katalyzátorů. 12. Chiroptické vlastnosti. Optická aktivita. Anisotropní refrakce, Optická rotační disperse (ORD). Anisotropní absorpce, Cirkulární dichroismus (CD). Využití CD a ORD při určování konfigurace a konformace. Polarimetrie, empirická pravidla a korelace. 13. Chiralita molekul bez center chirality. Nomenklatura. Alleny, spirany, atropoisomerie způsobená zábranou rotace kolem jednoduché vazby. Heliceny. Planární chiralita (Cyklofány, anuleny, metaloceny a d.). Kryptostereoisomerie.

Literature

WILEN, Samuel H. and Michael P. DOYLE. Basic organic stereochemistry. Edited by Ernest Ludwig Eliel. New York: Wiley-Interscience, 2001, xiv, 688. ISBN 0471374997. info
WILEN, Samuel H. and Lewis N. MANDER. Stereochemistry of organic compounds. Edited by Ernest Ludwig Eliel. New York: John Wiley & Sons, 1993, xv, 1267. ISBN 0471016705. info
JONAS, Jaroslav and Ctibor MAZAL. Konspekt ze základů organické stereochemie (Conspect of Basic Organic Stereochemistry). 1st ed. Brno: Masarykova univerzita, 2002, 87 pp. ISBN 80-210-2941-2. info
ELIEL, Ernest Ludwig. Stereochemie uhlíkatých sloučenin. Translated by Miloš Tichý. 1. vyd. Praha: Academia, 1970, 541 s. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

C4450 Organic Chemistry III - synthesis
(C3022||C3050)&&C5500&&C7410

The course is also listed under the following terms Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Spring 2004, Spring 2005, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.

Enrolment Statistics (recent)

Course Information

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

C5500 Stereochemistry of Organic Compounds

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