C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2012
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2011
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2010
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Timetable
Tue 12:00–13:50 C04/211
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2009
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
there are 12 fields of study the course is directly associated with, display
Course objectives
At the end of the course students should be able to develope advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2008
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2007
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: Structural Analysis C8950, Multinuclear NMR Spectroscopy C6800, or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2006
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: Structural Analysis C8950, Multinuclear NMR Spectroscopy C6800, or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 4 student(s).
Current registration and enrolment status: enrolled: 0/4, only registered: 0/4, only registered with preference (fields directly associated with the programme): 0/4
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2005
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
prof. RNDr. Jiří Pinkas, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: Structural Analysis C8950, Multinuclear NMR Spectroscopy C6800, or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 4 student(s).
Current registration and enrolment status: enrolled: 0/4, only registered: 0/4, only registered with preference (fields directly associated with the programme): 0/4
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2004
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination).
Teacher(s)
RNDr. Dalibor Dastych, Dr. (seminar tutor)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
prof. RNDr. Jiří Pinkas, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: Structural Analysis C8950, Multinuclear NMR Spectroscopy C6800, or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 6 student(s).
Current registration and enrolment status: enrolled: 0/6, only registered: 0/6, only registered with preference (fields directly associated with the programme): 0/6
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra, pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection HSQC, HMQC, HMBC, pulsed-field gradients 6. Measurement of 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 111 a 113Cd, 117 a 119Sn, 195Pt 7. Selective and shaped pulses, selective NOE, combined (hybrid) experiments - HSQC-TOCSY
Literature
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
Assessment methods (in Czech)
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the results of individual projects.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2003
Extent and Intensity
0/0/2. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination), z (credit).
Teacher(s)
RNDr. Dalibor Dastych, Dr. (seminar tutor)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
prof. RNDr. Jiří Pinkas, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites (in Czech)
Kurz je určen studentům kateder anorganické a organické chemie. Podmínkou účasti je absolvování jedné z následujících přednášek: NMR - Strukturní analýza C8950, Multinukleární NMR spektroskopie C 6800 nebo Fyzikálně chemické základy NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules.
Syllabus
  • 1. Basic 1D NMR spectra, pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection HSQC, HMQC, HMBC, pulsed-field gradients 6. Measurement of 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 111 a 113Cd, 117 a 119Sn, 195Pt 7. Selective and shaped pulses, selective NOE, combined (hybrid) experiments - HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Výuka probíhá u spektrometru v NMR laboratoři. Zápočet bude udělen po zpracování samostatného projektu (měření a interpretace neznámého vzorku).
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods in NMR Spectroscopy

Faculty of Science
Autumn 2002
Extent and Intensity
0/0/2. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: z (credit).
Teacher(s)
RNDr. Dalibor Dastych, Dr. (seminar tutor)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
prof. RNDr. Jiří Pinkas, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Jiří Pinkas, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites (in Czech)
Kurz je určen studentům kateder anorganické a organické chemie.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives (in Czech)
Pokročilé metody 1D i 2D NMR spektroskopie malých molekul.
Syllabus (in Czech)
  • 1. Základní 1D spektra, pulzní sekvence, nastavení základních akvizičních parametrů, kalibrace pulzů (přímá i nepřímá), výměna sond 2. Zpracování spekter a procesní parametry, dekonvoluce, teplotní měření 3. Homonukleární 2D experimenty: 31P-31P COSY, MQF-COSY, NOESY 4. Heteronukleární 2D experimenty: 31P-19F HETCOR, COLOC 5. Inverzní detekce HSQC, HMQC, HMBC, pulzní gradienty 6. Měření jádra 15N, přímá i inverzní detekce, jádra se spinem > 1/2 (14N, 17O), 29Si, 77Se, 111 a 113Cd, 117 a 119Sn, 125Te, 195Pt 7. Selektivní a tvarované pulzy, selektivní NOE, kombinované (hybridní) experimenty HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Výuka probíhá u spektrometru v NMR laboratoři. Zápočet bude udělen po zpracování samostatného projektu (měření a interpretace neznámého vzorku).
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2024

The course is not taught in Autumn 2024

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
In-person direct teaching
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2023

The course is not taught in Autumn 2023

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2022

The course is not taught in Autumn 2022

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
autumn 2021

The course is not taught in autumn 2021

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2020

The course is not taught in Autumn 2020

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2019

The course is not taught in Autumn 2019

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2018

The course is not taught in Autumn 2018

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
autumn 2017

The course is not taught in autumn 2017

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2016

The course is not taught in Autumn 2016

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2015

The course is not taught in Autumn 2015

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2014

The course is not taught in Autumn 2014

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2013

The course is not taught in Autumn 2013

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2011 - acreditation

The information about the term Autumn 2011 - acreditation is not made public

Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2010 - only for the accreditation
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Mgr. Jan Vícha, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: NMR Structural Analysis C8950 or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to develop advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
    recommended literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Teaching methods
Laboratory training and class discussion.
Assessment methods
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.

C7999 Advanced Methods of NMR Spectroscopy

Faculty of Science
Autumn 2007 - for the purpose of the accreditation
Extent and Intensity
0/0/2. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Radek Marek, Ph.D. (seminar tutor)
Guaranteed by
prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. RNDr. Radek Marek, Ph.D.
Prerequisites
Students should have knowledge of NMR at the level of the courses: Structural Analysis C8950, Multinuclear NMR Spectroscopy C6800, or Theoretical Concepts of NMR C5320
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 3 student(s).
Current registration and enrolment status: enrolled: 0/3, only registered: 0/3, only registered with preference (fields directly associated with the programme): 0/3
fields of study / plans the course is directly associated with
there are 14 fields of study the course is directly associated with, display
Course objectives
Advanced methods of 1D and 2D NMR spectroscopy of small molecules. The course is focused on hands-on experience of modern techniques in small molecule NMR spectroscopy.
Syllabus
  • 1. Basic 1D NMR spectra: pulse sequence, acquisition parameters, pulse calibration (direct and indirect), probehead exchange 2. Processing and parameters, temperature measurement 3. Homonuclear 2D chemical shift correlation experiments: 1H-1H COSY, 31P-31P COSY, MQF-COSY, NOESY 4. Heteronuclear 2D chemical shift correlation experiments: 31P-19F HETCOR, COLOC 5. Inverse (proton) detection: HSQC, HMQC, HMBC, pulsed-field gradients 6. Practical aspects for measuring various nuclei: 15N nucleus (direct and indirect detection), nucleus with spin > 1/2 (14N, 17O), 29Si, 77Se, 195Pt 7. Selective and shaped pulses, combined (hybrid) experiments: selective NOE, HSQC-TOCSY
Literature
  • Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry, Amsterdam, Pergamon, 1999, ISBN 0-08-042798-7
  • Braun, S. - Kalinowski, H.O. - Berger, S. 100 and More Basic NMR Experiments, Weinheim, VCH, 1996, ISBN 3-527-29091-5
Assessment methods (in Czech)
Presence in practical sessions in NMR laboratory is required. Final examination will be based on the structural analysis of unknown sample by using 2D NMR techniques.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught every week.
The course is also listed under the following terms Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012.
  • Enrolment Statistics (recent)