Course Information

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
In-person direct teaching

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

It is recommended to attend seminar C8953.

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 19. 2. to Sun 26. 5. Mon 15:00–16:50 B11/335

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

It is recommended to attend seminar C8953.

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 15:00–16:50 B11/335

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html
It is recommended to attend seminar C8953.

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 15:00–16:50 B11/335

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html
It is recommended to attend seminar C8953.

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 1. 3. to Fri 14. 5. Mon 15:00–16:50 online_BCH1

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 15:00–16:50 B11/335

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 18. 2. to Fri 17. 5. Mon 17:00–18:50 B11/335

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate for solving particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain nature of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 16:00–17:50 B11/305

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 20. 2. to Mon 22. 5. Mon 16:00–17:50 B11/235

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Learning outcomes

Student will be able to:
- suggest 1D and 2D NMR experiments appropriate to solve particular structural problem;
- describe principles of individual NMR techniques;
- compare and highlight differences among individual NMR correlation experiments;
- explain meanings of basic NMR parameters;
- interpret multidimensional NMR spectra of moderately complicated organic molecules, natural compounds, and simple biomacromolecules.

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 16:00–17:50 B11/235

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 30 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• CLARIDGE, Timothy D. W. High-resolution NMR techniques in organic chemistry. 1st ed. Amsterdam: Elsevier, 1999, xiv, 382. ISBN 0080427995. info
• KEELER, James. Understanding NMR spectroscopy. 2nd ed. Chichester: John Wiley and Sons, 2010, xiii, 511. ISBN 9780470746080. info

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 16:00–17:50 B11/235

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)
Cina Foroutannejad, Ph.D. (assistant)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Mon 9:00–10:50 B11/205

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Organic Chemistry (programme PřF, N-CH)

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 12:00–13:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 12:00–13:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Tue 16:00–17:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 26 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 13:00–14:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 10 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 14:00–15:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 14:00–15:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí.

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 13:00–14:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí.

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Timetable

Wed 14:00–15:50 C04/211

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Scalar and dipolar interactions - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí.

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C6390 Physical methods of organic chemistry - practical course
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Timetable

Wed 12:00–13:50 Kontaktujte učitele

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Scalar and dipolar interactions - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí.

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C6390 Physical methods of organic chemistry - practical course
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers, magnets, probes, tubes NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy Homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - 15N, 31P, 77Se (19F, 29Si, , 111 and 113Cd, 117 and 119Sn, 125Te, 195Pt, and 207Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. scalar and dipolar interactions - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects, scopes and limitations; - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation.

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí. Dvě vyučovací hodiny v polovině semestru budou vedeny v angličtině zahraničním přednášejícím (Prof. Dr. Erkki Kolehmainen, University of Jyväskylä, Finland).

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C6390 Physical methods of organic chemistry - practical course
• C7999 Advanced Methods of NMR Spectroscopy

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR - Strukturní analýza

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is oriented to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers, magnets, probes, tubes NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy Homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - 15N, 31P, 77Se (19F, 29Si, , 111 and 113Cd, 117 and 119Sn, 125Te, 195Pt, and 207Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. scalar and dipolar interactions - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects, scopes and limitations; - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation.

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C6390 Physical methods of organic chemistry - practical course
• C7999 Advanced Methods of NMR Spectroscopy

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR - Strukturní analýza

Extent and Intensity

2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is oriented to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers, magnets, probes, tubes NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy Homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - 15N, 31P, 77Se (19F, 29Si, , 111 and 113Cd, 117 and 119Sn, 125Te, 195Pt, and 207Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. scalar and dipolar interactions - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects, scopes and limitations; - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation.

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C6390 Physical methods of organic chemistry - practical course
• C7300 Methods of chemical research - laboratory course

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR - Strukturní analýza

Extent and Intensity

2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 23 fields of study the course is directly associated with, display

Course objectives (in Czech)

Metody magnetické rezonance, chemický posun, interakční konstanta, FT-NMR, relaxace jader, selektivní excitace, potlačení signálu rozpouštědla, konstrukce spektrometrů, magnety, sondy, kyvety, editační techniky (APT), přenos polarizace (INEPT, DEPT), NMR spektroskopie ve více dimenzích, homonukleární korelace chemických posunů (COSY, LR-COSY, TOCSY), heteronukleární korelace chemických posunů (HETCOR, COLOC), měření J konstant, dipolární interakce (selektivní NOE, NOESY), vícekvantová spektroskopie (MQF-COSY, INADEQUATE), NMR spektroskopie jiných jader než 1H a 13C (15N, 31P, 19F, 77Se, 195Pt) inverzní experimenty (HMQC, HSQC, HMBC, HSQC-TOCSY), gradientní spektroskopie, J konstanty a dihedrální úhly, NOE a meziatomové vzdálenosti, logická struktura analýzy, citlivost experimentů, příklady a interpretace spekter.

Literature

• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR - Strukturní analýza

Extent and Intensity

2/0/0. 3 credit(s). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
Chemistry Section – Faculty of Science

Prerequisites

physical, analytical, and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 16 fields of study the course is directly associated with, display

Syllabus (in Czech)

• Metody magnetické rezonance, chemický posun, interakční konstanta, FT-NMR, relaxace jader, selektivní excitace, potlačení signálu rozpouštědla, konstrukce spektrometrů, magnety, sondy, kyvety, editační techniky (APT), přenos polarizace (INEPT, DEPT), NMR spektroskopie ve více dimenzích, homonukleární korelace chemických posunů (COSY, LR-COSY, TOCSY), heteronukleární korelace chemických posunů (HETCOR, COLOC), měření J konstant, dipolární interakce (selektivní NOE, NOESY), vícekvantová spektroskopie (MQF-COSY, INADEQUATE), NMR spektroskopie jiných jader než 1H a 13C (15N, 31P, 19F, 77Se, 195Pt) inverzní experimenty (HMQC, HSQC, HMBC, HSQC-TOCSY), gradientní spektroskopie, J konstanty a dihedrální úhly, NOE a meziatomové vzdálenosti, logická struktura analýzy, citlivost experimentů, příklady a interpretace spekter.

Literature

• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

C8950 NMR Structural Analysis

The information about the term spring 2012 - acreditation is not made public

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

required literature
• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987

recommended literature
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info

not specified
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.
• C8953 NMR Structural Analysis - seminar

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to understand NMR spectroscopy as one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to interpreting the spectra and extracting the information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Teaching methods

Lectures

Assessment methods

lectures, sessions on interpreting 2D spectra, written exam

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

Teacher's information

http://ncbr.chemi.muni.cz/~rmarek/c8950/C8950.html

C8950 NMR Structural Analysis

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Radek Marek, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Radek Marek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science

Prerequisites

physical and organic chemistry, physics

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 21 fields of study the course is directly associated with, display

Course objectives

NMR spectroscopy is one of the most important methods of structural analysis. Graduates are expected to be oriented in the structural analysis of natural products and organic compounds by using high-resolution NMR spectroscopy. The main emphasis is directed to the interpretation and extraction of information from basic 2D spectra (COSY, NOESY, HSQC, HMBC).

Syllabus

• 1. Basic aspects of NMR - introduction, methods of magnetic resonance, nuclear interactions, origin of NMR signal, chemical shift, spin-spin scalar coupling, examples, Fourier transformation - nuclear relaxation (inversion recovery), selective excitation, suppression of solvent signal, NOE; 2. Construction of spectrometers - magnets, probes, tubes, NMR-HPLC, NMR-MS; 3. Editation techniques - spin echo, APT - polarisation transfer, INEPT, DEPT; 4. Multidimensional NMR spectroscopy - homonuclear shift correlation - correlation spectroscopy (COSY) - multiple bond interactions (LR-COSY, Relayed COSY) - TOCSY; 5. Heteronuclear chemical shift correlation - single bond (HETCOR) - multiple bond (LR-HETCOR, COLOC); 6. Measurement of J couplings - J spectroscopy - other techniques - chemical shift correlations, time domain; 7. Dipolar interactions - selective NOE - 2D NOESY; 8. Multiple-quantum spectroscopy - MQF-COSY - INADEQUATE; 9. NMR spectroscopy of various nuclei - ¹⁵N, ³¹P, ⁷⁷Se (¹⁹F, ²⁹Si, , ¹¹¹Cd and ¹¹³Cd, ¹¹⁷Sn and ¹¹⁹Sn, ¹²⁵Te, ¹⁹⁵Pt, and ²⁰⁷Pb); 10. Inverse-detected experiments - single bond (HMQC, HSQC) - multiple bond (HMBC, HSQC) - hybrid experiments (HMQC-TOCSY, HSQC-TOCSY, HSQC-NOESY; 11. Gradient assisted spectroscopy - homonuclear shift correlations - NOESY - inverse-detected heteronuclear shift correlations; 12. Indirect spin-spin coupling and direct dipolar interaction - information for structural interpretation - J couplings and dihedral angles - NOE and interatomic distances - input for molecular mechanics; 13. Practical aspects - scopes and limitations - probehead selection, logical structure of analysis, sensitivity of experiments; 14. Practical examples and interpretation

Literature

• Claridge, Timothy D.W. High-Resolution NMR Techniques in Organic Chemistry: Pergamon, 1999 382s. ISBN 0-08-0427987
• RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995, xvi, 430. ISBN 0120663201. info
• RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989, 578 s. ISBN 0444873163. info
• BREITMAIER, Eberhard. Structure elucidation by NMR in organic chemistry : a practical guide. Translated by Julia Wade. Chichester: John Wiley & Sons, 1993, 265 s. ISBN 0471933813. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 150 and more basic NMR experiments :a practical course. 2nd exp. ed. Weinheim: Wiley-VCH, 1998, 595 s. ISBN 3-527-29512-7. info
• BRAUN, Siegmar, Hans - Otto KALINOWSKI and Stefan BERGER. 100 and more basic NMR experiments :a practical course. Weinheim: VCH Verlagsgesellschaft, 1996, xii, 418 s. ISBN 3-527-29091-5. info
• http://staffold.vscht.cz/nmr/subpages/predmet.html

Assessment methods (in Czech)

výuka probíhá každý týden, zakončení zkouškou s písemnou i ústní částí.

Language of instruction

Czech

Follow-Up Courses

• C5320 Theoretical Concepts of Nuclear Magnetic Resonance
• C7998 Basics of Experimental NMR Spectroscopy
• C7999 Advanced Methods of NMR Spectroscopy
• C8951 Solid-State NMR Spectroscopy - Basic Principles and Application in Chemistry.

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• C8953 NMR Structural Analysis - seminar
  C8950 || NOW(C8950)  

• Enrolment Statistics (recent)