C8885 Supramolecular Chemistry

Faculty of Science
Spring 2020
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
doc. RNDr. Ctibor Mazal, CSc. (lecturer)
Guaranteed by
doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Wed 10:00–11:50 A08/309
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of this course, students should be able to understand the basic concepts and principles of supramolecular chemistry. Main topics of the course can be summarized as follows: to understand the basic intermolecular interactions; to learn about typical compounds important in study of recognition of ions and neutral molecules; to demonstrate the basic principles of the supramolecular chemistry on reactivity and catalysis, transport processes, self-assembly processes, liquid crystals, as well as on design of supramolecular devices.
Learning outcomes
Student will be able to apply the knowledge about molecular recognition of cations, anions and neutral molecules, together with characterization of representative kinds of receptors; will be able to utilize basic methods of investigation of supramolecular phenomena and processes; to explain principles and function of some molecular and supramolecular devices.
Syllabus
  • 1. Concept of supramolecular chemistry. Basic principles. Weak intermolecular interactions (Coulombic, H-bond, cation-p interaction, p-p stacking, van der Waals interaction, hydrophobic effect).
  • 2. Molecular recognition. Recognition and selectivity. Thermodynamic and kinetic selectivity. Molecular receptors. Chelate and macrocyclic effects. Pre-organization and complementarity. Recognition of cations, anions and neutral molecules.
  • 3. Molecular recognition of cations. Crown ethers. Cryptands. Spherands. Binding of ammonium cations.
  • 4. Calix[n]arenes. Structure and conformation. Simple chemical transformations. Complexation of cations, anions and neutral molecules.
  • 5. Anion recognition. Bioreceptors of anions.
  • 6. Recognition of neutral molecules. Inorganic and organic clathrates (Zeolites, urea, dianin etc.). Cyclodextrins.
  • 7. Structure and stability of molecular complexes. Complexation constant. Complex stoichiometry determination.
  • 8. Dendrimers. Synthesis and properties of dendrimers. Supramolecular applications.
  • 9. Supramolecular synthesis, crystal engineering. Crystal growth. Design strategy.
  • 10. Self-assembly processes (SA). Biochemical SA. SA in chemical synthesis. Catenanes and rotaxanes. Helicates. Programmed supramolecular syntheses.
  • 11. Supramolecular reactivity and catalysis. Examples of catalytic systems. Biological mimics. Enzym models.
  • 12. Supramolecular interactions in transport processes. Surfactants. Micelles, vesicles.
  • 13. Supramolecular devices. Semiochemistry. Photonic devices. Electronic devices – switches, wires, semiconductors, rectifiers. NLO materials.
  • 14. Liquid crystals. Structure and properties of LC. Selected applications.
Literature
  • LHOTÁK, Pavel and Ivan STIBOR. Molekulární design. Vyd. 1. Praha: Vydavatelství VŠCHT, 1997, [267] s. ISBN 80-7080-294-4. info
  • Steed, Jonathan, W. - Atwood, Jerry L. Supramolecular Chemistry. Chichester: Wiley, 2000
  • LEHN, Jean-Marie. Supermolecular chemistry :concepts and perspectives. Weinheim: VCH Verlagsgesellschaft, 1995, 271 s. ISBN 3-527-29311-6. info
  • VÖGTLE, Fritz. Supramolecular chemistry : an introduction. Translated by Michel Grognuz. Chichester: John Wiley & Sons, 1991, viii, 337. ISBN 0471940615. info
Teaching methods
Lectures
Assessment methods
Oral or written exam.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Autumn 2006, Autumn 2007, Autumn 2008, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2020, recent)
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