Bi0580 Developmetal Genetics

Faculty of Science
Autumn 2019
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Boris Vyskot, DrSc. (lecturer)
Mgr. Ivana Kupčíková, DiS. (assistant)
Guaranteed by
prof. RNDr. Boris Vyskot, DrSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Boris Vyskot, DrSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Mon 14:00–15:50 BFU
Prerequisites
(SOUHLAS || Ex_3162 Obecná genetika || Imp_9126 Obecná genetika || B1900 Basic genetics || BMB32 Basic genetics || B6730 Basic genetics || B8470 Genetics || B3060 Basic genetics || Bi3060 Basic genetics ) && ( Ex_3065 Molekulární biologie || Imp_9115 Molekulární biologie || B3120 Molecular and cell biology || B4020 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || Bi4010 Essential molecular biology || Bi4020 Molecular biology ) && ( Bi6081 Bachelor state exam of Molecular biology and genetics || Bi6087 Bachelor state exam of Cellular and molecular diagnostics || Bi6088 Bc. state exam Klin.Gen.Diagn. || SOUHLAS)
Foreign students are welcome (relevant literature in English is available).
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of this course, students should be able to understand common features of developmental processes in phylogenetically distant groups of organisms, genetic and epigenetic fundamentals of developmental processes on molecular level.
Learning outcomes
At the end of this course, students should be able to understand common features of developmental processes in phylogenetically distant groups of organisms, genetic and epigenetic fundamentals of developmental processes on molecular level.
Syllabus
  • (1) General principles of developmental genetics, history, embryonic induction (Spemann), models of flags (Wolpert), reaction-diffuse model of development (Turing), regulative and mosaic development, homeosis (Bateson, Goethe), programmed cell death, preformism and epigenesis (Aristotle), germ-line (Weismann), genes with maternal effects, morphallaxis and epimorphosis
  • (2) Developmental and epigenetic processes in bacteria (Bacillus subtilis), fungi (yeast, Dictyostelium) and primitive animal models (Paramecium, Hydra, Caenorhabditis)
  • (3) Flatworms – rediscovered model of developmental biology: regeneration, neurobiology, allometry, RNA-interference
  • (4) Drosophila melanogaster – the queen of developmental genetics: genetic control cascade of embryogenesis, maternal and zygotic genes, homeotic genes, colinearity, imaginal discs, homeotic transdetermination
  • (5) Deuterostomia as important models for developmental studies: sea urchin, fish, amphibians, birds, mammals
  • (6) Medical aspects of developmental biology: therapy of infertility, malformations, teratogenesis, candidate genes, positional cloning, stem cells, DNA therapy, epigenetic diseases
  • (7) Alternative models of plant developmental genetics: Anabaena, Acetabularia, Chlamydomonas, Volvox, Fucus, Marchantia, Physcomitrella, Ceratopteris, Populus, Antirrhinum, Linaria, Linum, Craterostigma, Zinnia, Silene, Zea, Oryza, Brachypodium, Gagea, Eleocharis, orchids
  • (8) Arabidopsis thaliana model: gametophyte and sporophyte, imprinting in endosperm, control of embryogenesis, regulative development, control of flowering, MADS-box genes, homeobox genes, Polycomb proteins (Medea), paramutations, epimutations
  • (9) Sex and its determination, genetically, hormone and epigenetically controlled sexuality, structure and evolution of sex chromosomes, gynandromorphy, dioecy, X- and Y-linked inheritance, molecular mechanisms of sex determination
  • (10) Principles of epigenetic inheritance, mechanisms of epigenetic processes, evolutionary and developmental processes (or evo/devo): heterotopic changes, heterochronic changes, environmental adaptation
Literature
    required literature
  • VYSKOT, Boris. Epigenetika. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2010, 150 s. ISBN 9788024425344. info
  • VYSKOT, Boris. Přehled vývojové biologie a genetiky. Praha: Ústav molekulární genetiky AV ČR, 1999, 241 s. ISBN 80-902588-1-6. info
    recommended literature
  • Principles of developmental genetics. Edited by Sally A. Moody. Boston: Elsevier Academic Press, 2007, xiv, 1055. ISBN 9780123695482. info
Teaching methods
Lectures are based on power-point pictures, tables and texts elaborated according to textbooks, monographs and scientific papers which are explained and complemented with live commentaries.
Assessment methods
Oral examination follows the written test in which students should answer 50 questions covering main topics of the lecture. During the oral examinations the students have to prove their knowledge on particular examples. To pass the exam they should answer 70% of the answers.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Teacher's information
http://www.ibp.cz/labs/PDG/
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Spring 2003, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2019, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2019/Bi0580