PřF:C8840 Chemistry of macrocycles - Course Information
C8840 Chemistry of macrocyclic compounds
Faculty of ScienceAutumn 2022
- Extent and Intensity
- 2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
- Teacher(s)
- prof. RNDr. Přemysl Lubal, Ph.D. (lecturer)
- Guaranteed by
- prof. RNDr. Přemysl Lubal, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Přemysl Lubal, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science - Prerequisites
- The main prerequisites to attend this lecture is passing of basic courses Inorganic chemistry I (C1061), Inorganic chemistry II (C2062), Organic chemistry I (C2021), Organic chemistry II (C3022), Analytical chemistry I (C3100) and Analytical chemistry II (C4050). It also suitable to visit course C8885 Supramolecular chemistry (it is not required).
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Analytical Biochemistry (Eng.) (programme PřF, N-BCH)
- Analytical Biochemistry (programme PřF, N-BCH)
- Analytical Chemistry (Eng.) (programme PřF, D-CH4)
- Analytical Chemistry (programme PřF, D-CH4)
- Analytical Chemistry (programme PřF, N-CH)
- Inorganic Chemistry (Eng.) (programme PřF, D-CH4)
- Inorganic Chemistry (programme PřF, D-CH4)
- Inorganic Chemistry (programme PřF, N-CH)
- Bioanalyst - Specialist in Laboratory Methods (programme PřF, N-BCH)
- Biophysics (Eng.) (programme PřF, D-FY4)
- Biophysics (programme PřF, D-FY4)
- Biophysics (programme PřF, N-FY)
- Biophysics (programme PřF, N-FY, specialization Aplikovaná biofyzika)
- Biophysics (programme PřF, N-FY, specialization Molekulární biofyzika)
- Biochemistry (Eng.) (programme PřF, D-BCH4)
- Biochemistry (Eng.) (programme PřF, N-BCH)
- Biochemistry (programme PřF, D-BCH4)
- Biochemistry (programme PřF, N-BCH)
- Biomolecular Chemistry (Eng.) (programme PřF, D-BCH4)
- Biomolecular Chemistry (Eng.) (programme PřF, N-BCH)
- Biomolecular Chemistry (programme PřF, D-BCH4)
- Biomolecular Chemistry (programme PřF, N-BCH)
- Bio-omics (Eng.) (programme PřF, D-VZP)
- Bio-omics (programme PřF, D-VZP)
- Physical Chemistry (Eng.) (programme PřF, D-CH4)
- Physical Chemistry (programme PřF, D-CH4)
- Physical Chemistry (programme PřF, N-CH)
- Environmental Chemistry (programme PřF, N-CH)
- Chemoinformatics and Bioinformatics (programme PřF, N-BCH)
- Materials Chemistry (Eng.) (programme PřF, D-CH4)
- Materials Chemistry (programme PřF, D-CH4)
- Organic Chemistry (programme PřF, N-CH)
- Structural Chemistry (programme PřF, N-CH)
- Course objectives
- The lecture is focused on the understanding and explanation of reactivity and properties of macrocylic compounds and it is accompanied by examples taken from literature or from experimental experiences of lecturer. In addition, the potential application of macrocyclic complexes in practice is mentioned.
- Learning outcomes
- Student understands and is able to explain the reactivity and properties of macrocylic compounds. He/she can ppropose the apllication of macrocyclic complexes in practice.
- Syllabus
- 1. Introduction into macrocylic chemistry (nomenclature, natural macrocyles, importance).
- 2. Types of macrocylic ligands and their complexes, cyclic polyamines and porphyrines, cyclic polyethers (crowns, polyethers, cryptands, cavitands, calixarens), cyclic ligands with other donor atoms than O or N, polycore and polymer macrocycles, catenans and catenands, macrocyclic sugars, robust macrocycles, stereoisomerism of macrocycles, "hole-size" concept.
- 3. Aspects of macrocycle synthesis. Free ligands - non-template synthesis, reaction of ring formation (synthesis under high and low dilution).
- 4. Complexes - non-template synthesis, template synthesis (influence of physical and chemical conditions on kind and yield of reaction - kinds of template effects), in situ reactions. Derivatization of macrocycles - introduction of functional groups into cyclic skeleton and protection of cyclic skeleton.
- 5. Chelate and macrocyclic effect - origin and quantification. Experimental techniques suitable for study of reactivity of macrocyclic compounds.
- 6. Thermodynamic aspect - selectivity for ions. Kinetic aspect - formation and dissociation kinetics.
- 7. Reactivity of complexes and their redox properties. Stabilisation of less common oxidation states - "metal-centered", "ligand-centered" oxidation and reduction. Substitution reactions in axial site, reaction of coordinated macrocyclic ligand, demetallic reactions and ionic exchange reactions.
- 8. Macrocyclic systems. Complexation of metal ions (cyclic polyethers, polyamines and polyimines; cryptands, calixarenes, etc.).
- 9. "Host-guest" chemistry - complexation of organic cations.
- 10. Complexation of organic anions.
- 11. Complexation of neutral compounds cyclodextrines.
- 12. The use of macrocyclic ligands and their complexes in chemistry, biology, medicine - examples.
- Literature
- Constable, Edwin C., Coordination Chemistry of Macrocyclic Compounds, Oxford University Press, Oxford 1999.
- MARTELL, Arthur E. and Robert D. HANCOCK. Metal complexes in aqueous solutions. New York: Plenum Press, 1996, x, 253 s. ISBN 0-306-45248-0. info
- Lindoy L.F., The Chemistry of Macrocylic Ligand Complexes, Cambridge University Press, Cambridge 1989.
- Teaching methods
- lectures
- Assessment methods
- The lecture is presented during term or in block according to agreement with lecturer. The knowledge of students is verified by oral exam which will be performed personally or remotely according to the current epidemiological situation.
- Language of instruction
- English
- Further Comments
- Study Materials
The course is taught once in two years.
The course is taught: every week.
- Enrolment Statistics (Autumn 2022, recent)
- Permalink: https://is.muni.cz/course/sci/autumn2022/C8840