Publication Records

MIKUŠOVÁ, Petra, Zuzana TOUŠOVÁ, Luděk SEHNAL, Jan KUTA, K. GRABICOVA, G. FEDOROVA, Martin MAREK, R. GRABIC and Klára HILSCHEROVÁ. Identification of new endocrine disruptive transthyretin ligands in polluted waters using pull-down assay coupled to non-target mass spectrometry. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2024, vol. 471, June 2024, p. 1-12. ISSN 0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2024.134240.

BENEŠOVÁ, Iva, Rudolf NENUTIL, Adam Paulin URMINSKÝ, Erika LATTOVÁ, Lukas UHRIK, Peter GRELL, Filip Zavadil KOKAS, Jana HALÁMKOVÁ, Zbyněk ZDRÁHAL, Bořivoj VOJTĚŠEK, Miloš V NOVOTNÝ and Lenka HERNYCHOVÁ. N-glycan profiling of tissue samples to aid breast cancer subtyping. Nature Scientific Reports. London: NATURE RESEARCH, 2024. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-023-51021-3.

KUNKA, Antonín, Sérgio Manuel MARQUES, Martin HAVLÁSEK, Michal VAŠINA, Nikola VELÁTOVÁ, Lucia CENGELOVÁ, David KOVÁŘ, Jiří DAMBORSKÝ, Martin MAREK, David BEDNÁŘ and Zbyněk PROKOP. Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning. ACS Catalysis. WASHINGTON: AMER CHEMICAL SOC, 2023, vol. 13, No 19, p. 12506-12518. ISSN 2155-5435. Available from: https://dx.doi.org/10.1021/acscatal.3c02575.

ŠNAJDAROVÁ, Karolína, Sérgio Manuel MARQUES, Jiří DAMBORSKÝ, David BEDNÁŘ and Martin MAREK. Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum. Acta Crystallographica Section D: Structural Biology. Chester: International Union of Crystallography, 2023, vol. 79, November, p. 956-970. ISSN 2059-7983. Available from: https://dx.doi.org/10.1107/S2059798323006642.

SMITH, Andrea, Martin TOUL, Daniel PLUSKAL, Racha BAATALLAH, Glwadys GAGNOT, José Gaspar RANGEL PAMPLONA PIZARRO PINTO, Vinicius T. T. SANTANA, Markéta STUCHLÁ, Petr NEUGEBAUER, Pimchai CHAIYEN, Jiří DAMBORSKÝ, David BEDNÁŘ, Yves L. L. JANIN, Zbyněk PROKOP and Martin MAREK. Catalytic mechanism for Renilla-type luciferases. Nature Catalysis. Nature Portfolio, 2023, vol. 6, No 1, p. 23-38. ISSN 2520-1158. Available from: https://dx.doi.org/10.1038/s41929-022-00895-z.

GAO, Tadeja, Jiří DAMBORSKÝ, Yves L. JANIN and Martin MAREK. Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues. ChemCatChem. WEINHEIM: WILEY-V C H VERLAG GMBH, 2023, vol. 15, No 19, p. 1-16. ISSN 1867-3880. Available from: https://dx.doi.org/10.1002/cctc.202300745.

NEMERGUT, Michal, Sérgio Manuel MARQUES, Lukáš UHRÍK, Tereza VÁŇOVÁ, Markéta NEZVEDOVÁ, Darshak Chandulal GADARA, Durga JHA, Jan TULIS, Veronika NOVÁKOVÁ, Joan PLANAS IGLESIAS, Antonín KUNKA, Anthony Thomas P LEGRAND, Hana HŘÍBKOVÁ, Veronika POSPÍŠILOVÁ, Jiří SEDMÍK, Jan RAŠKA, Zbyněk PROKOP, Jiří DAMBORSKÝ, Dáša BOHAČIAKOVÁ, Zdeněk SPÁČIL, Lenka HERNYCHOVÁ, David BEDNÁŘ and Martin MAREK. Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate. Molecular Neurodegeneration. England: BMC, 2023, vol. 18, No 1, p. 1-25. ISSN 1750-1326. Available from: https://dx.doi.org/10.1186/s13024-023-00620-9.

TOUL, Martin, Veronika SLONKOVÁ, Jan MIČAN, Adam Paulin URMINSKÝ, Maria TOMKOVA, Erik SEDLÁK, David BEDNÁŘ, Jiří DAMBORSKÝ, Lenka HERNYCHOVÁ and Zbyněk PROKOP. Identification, characterization, and engineering of glycosylation in thrombolytics. Biotechnology Advances. OXFORD: Elsevier, 2023, vol. 66, September 2023, p. 1-23. ISSN 0734-9750. Available from: https://dx.doi.org/10.1016/j.biotechadv.2023.108174.

NEMERGUT, Michal, Daniel PLUSKAL, Jana HORÁČKOVÁ, Tereza ŠUSTROVÁ, Jan TULIS, Tomáš BÁRTA, Racha BAATALLAH, Glwadys GAGNOT, Veronika NOVÁKOVÁ, Marika MAJEROVÁ, Karolina SEDLÁČKOVÁ, Sérgio Manuel MARQUES, Martin TOUL, Jiří DAMBORSKÝ, Zbyněk PROKOP, David BEDNÁŘ, Yves L. JANIN and Martin MAREK. Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nature Communications. Berlin: Nature, 2023, vol. 14, No 1, p. 1-20. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-023-43403-y.

GUERRA-SLOMPO, Eloise Pavao, Gisele Fernanda Assine PICCHI-CONSTANTE, Martin MAREK, Christophe ROMIER, Wolfgang SIPPL and Nilson Ivo Tonin ZANCHIN. In cellulo and in vivo assays for compound testing against Trypanosoma cruzi. STAR Protocols. United States: Cell Press, 2023, vol. 4, No 1, p. 1-42. ISSN 2666-1667. Available from: https://dx.doi.org/10.1016/j.xpro.2023.102058.

CHMELOVÁ, Klaudia, Tadeja GAO, Martin POLÁK, Andrea SMITH, Tristan I. CROLL, Tanvir SHAIKH, Jana ŠKAŘUPOVÁ, Radka CHALOUPKOVÁ, Kay DIEDERICHS, Randy J. READ, Jiří DAMBORSKÝ, Jiří NOVÁČEK and Martin MAREK. Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography. Protein Science. Hoboken: Wiley, 2023, vol. 32, No 10, p. 1-22. ISSN 0961-8368. Available from: https://dx.doi.org/10.1002/pro.4751.

UHRIK, Lukas, Tomas HENEK, Joan PLANAS IGLESIAS, Josef KUCERA, Jiří DAMBORSKÝ, Martin MAREK and Lenka HERNYCHOVA. Study of Protein Conformational Dynamics Using Hydrogen/Deuterium Exchange Mass Spectrometry. In Ângela Sousa, Luis Passarinha. Advanced Methods in Structural Biology. New York: Springer Nature, 2023, p. 293-318. 1. ISBN 978-1-0716-3146-1. Available from: https://dx.doi.org/10.1007/978-1-0716-3147-8_18.

NIKITIN, Dmitri, Jan MIČAN, Martin TOUL, David BEDNÁŘ, Michaela PEŠKOVÁ, Patrícia KITTOVÁ, Sandra THALEROVÁ, Jan VÍTEČEK, Jiří DAMBORSKÝ, Robert MIKULÍK, Sarel J. FLEISHMAN, Zbyněk PROKOP and Martin MAREK. Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin. Computational and Structural Biotechnology Journal. Amsterdam: Elsevier, 2022, vol. 20, May 2022, p. 1366-1377. ISSN 2001-0370. Available from: https://dx.doi.org/10.1016/j.csbj.2022.03.004.

TOUL, Martin, Dmitri NIKITIN, Martin MAREK, Jiří DAMBORSKÝ and Zbyněk PROKOP. Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase. ACS Catalysis. WASHINGTON: AMER CHEMICAL SOC, 2022, vol. 12, No 7, p. 3807-3814. ISSN 2155-5435. Available from: https://dx.doi.org/10.1021/acscatal.1c05042.

TOUL, Martin, Jan MIČAN, Veronika SLONKOVÁ, Dmitri NIKITIN, Martin MAREK, David BEDNÁŘ, Jiří DAMBORSKÝ and Zbyněk PROKOP. Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase. Stroke. Dallas: Lippincott Williams & Wilkins, 2022, vol. 53, No 10, p. 3235-3237. ISSN 0039-2499. Available from: https://dx.doi.org/10.1161/STROKEAHA.122.040219.

BENEŠOVÁ, Iva, Adam Paulin URMINSKÝ, Jana HALÁMKOVÁ and Lenka HERNYCHOVÁ. Changes of serum protein N-glycosylation in cancer. Časopis Klinická onkologie. Praha: Česká lékařská společnost J. E. Purkyně, 2022, vol. 35, No 3, p. 174-180. ISSN 0862-495X. Available from: https://dx.doi.org/10.48095/ccko2022174.

NEMERGUT, Michal, Tereza BÁŤKOVÁ, Dana VIGAŠOVÁ, Milan BARTOŠ, Martina HLOZANKOVA, Andrea SMITH, Barbora LIŠKOVÁ, Kateřina SHEARDOVÁ, Martin VYHNALEK, Jakub HORT, Jan LACZO, Ingrid KOVÁČOVÁ, Michal ŠITINA, Radoslav MATEJ, Radim JANČÁLEK, Martin MAREK and Jiří DAMBORSKÝ. Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease. Science of the Total Environment. Amsterdam: Elsevier Science, 2022, vol. 844, October 2022, p. 1-7. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2022.157114.

MARQUES, Sérgio Manuel, Michaela SLÁNSKÁ, Klaudia CHMELOVÁ, Radka CHALOUPKOVÁ, Martin MAREK, Spencer CLARK, Jiří DAMBORSKÝ, Eric T. KOOL, David BEDNÁŘ and Zbyněk PROKOP. Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling. JACS AU. WASHINGTON: AMER CHEMICAL SOC, 2022, vol. 2, No 6, p. 1324-1337. ISSN 2691-3704. Available from: https://dx.doi.org/10.1021/jacsau.2c00002.

ŠTOURAČ, Jan, Rayyan Tariq KHAN, Simeon BORKO, Petra POKORNÁ, Adam DOBIÁŠ, José Gaspar RANGEL PAMPLONA PIZARRO PINTO, Jaroslav ŠTĚRBA, Ondřej SLABÝ, Jiří DAMBORSKÝ and David BEDNÁŘ. PredictSNP Onco 1.0. 2022.

VAŠINA, Michal, Jan VELECKÝ, Joan PLANAS IGLESIAS, Sérgio Manuel MARQUES, Jana ŠKAŘUPOVÁ, Jiří DAMBORSKÝ, David BEDNÁŘ, Stanislav MAZURENKO and Zbyněk PROKOP. Tools for computational design and high-throughput screening of therapeutic enzymes. ADVANCED DRUG DELIVERY REVIEWS. NETHERLANDS: ELSEVIER, 2022, vol. 183, April 2022, p. 1-16. ISSN 0169-409X. Available from: https://dx.doi.org/10.1016/j.addr.2022.114143.

DAMBORSKÝ, Jiří, David BEDNÁŘ, Zbyněk PROKOP, Martin MAREK, Stanislav MAZURENKO, Jan ŠTOURAČ, Sérgio Manuel MARQUES, Gabriela Filipa FONSECA PINTO, Joan PLANAS IGLESIAS, Miloš MUSIL, Jiří HON, Ondřej VÁVRA, Rayyan Tariq KHAN, Jiří FILIPOVIČ and Barbora KOZLÍKOVÁ. Computational enzyme design for metabolic engineering. In The 45th FEBS Congress. 2021. ISSN 2211-5463.

MARKOVÁ, Klára, Antonín KUNKA, Klaudia CHMELOVÁ, Martin HAVLÁSEK, Petra BABKOVÁ, Sérgio Manuel MARQUES, Michal VAŠINA, Joan PLANAS IGLESIAS, Radka CHALOUPKOVÁ, David BEDNÁŘ, Zbyněk PROKOP, Jiří DAMBORSKÝ and Martin MAREK. Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers. ACS Catalysis. WASHINGTON: AMER CHEMICAL SOC, 2021, vol. 11, No 21, p. 12864-12885. ISSN 2155-5435. Available from: https://dx.doi.org/10.1021/acscatal.1c03343.

MAREK, Martin, Jiří DAMBORSKÝ, David BEDNÁŘ, Daniel PLUSKAL, Marika MAJEROVÁ and Joan PLANAS IGLESIAS. Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi (Designed and synthesized genes coding for new luciferase enzymes with confirmed properties). 2021.

TOUL, Martin, Andrea SMITH, José Gaspar RANGEL PAMPLONA PIZARRO PINTO, Martin MAREK, Lenka HERNYCHOVÁ, Veronika LIŠKOVÁ, Daniel PLUSKAL, Stephane EMOND, Mark DÖRR, Joan PLANAS IGLESIAS, Radka CHALOUPKOVÁ, David BEDNÁŘ, Zbyněk PROKOP, Uwe T. BORNSCHEUER, Florian HOLLFELDER and Jiří DAMBORSKÝ. Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase. In The 45th FEBS Congress. 2021. ISSN 2211-5463.

SCHENKMAYEROVÁ, Andrea, José Gaspar RANGEL PAMPLONA PIZARRO PINTO, Martin TOUL, Martin MAREK, Lenka HERNYCHOVÁ, Joan PLANAS IGLESIAS, Veronika LIŠKOVÁ, Daniel PLUSKAL, Michal VAŠINA, Stephane EMOND, Mark DÖRR, Radka CHALOUPKOVÁ, David BEDNÁŘ, Zbyněk PROKOP, Florian HOLLFELDER, Uwe T. BORNSCHEUER and Jiří DAMBORSKÝ. Engineering the protein dynamics of an ancestral luciferase. Nature Communications. London: Nature Publishing Group, 2021, vol. 12, No 1, p. 3616-3631. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-021-23450-z.

VIGAŠOVÁ, Dana, Michal NEMERGUT, Barbora LIŠKOVÁ and Jiří DAMBORSKÝ. Multi-pathogen infections and Alzheimer's disease. Microbial Cell Factories. London: BioMed Central Ltd, 2021, vol. 20, No 1, p. 25-37. ISSN 1475-2859. Available from: https://dx.doi.org/10.1186/s12934-021-01520-7.

MAREK, Martin, E. RAMOS-MORALES, G.F.A. PICCHI-CONSTANTE, T. BAYER, C. NORSTROM, D. HERP, P.A. SALES, E.P. GUERRA-SLOMPO, K. HAUSMANN, A. CHAKRABARTI, T.B. SHAIK, A. MERZ, E. TROESCH, K. SCHMIDTKUNZ, S. GOLDENBERG, R.J. PIERCE, MM MOURAO, M.M. JUNG, J. SCHULTZ, W. SIPPL, N.I.T. ZANCHIN and C. ROMIER. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Reports. CAMBRIDGE: Cell Press, 2021, vol. 37, No 12, p. 1-17, "e1-e9", 26 pp. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2021.110129.

RAMOS-MORALES, Elizabeth, Efil BAYAM, Jordi DEL-POZO-RODRIGUEZ, Thalia SALINAS-GIEGE, Martin MAREK, Ramos-Morales, E (Ramos- TILLY, Philippe WOLFF, Edouard TROESCH, Eric ENNIFAR, Laurence DROUARD, Juliette D. GODIN and Christophe ROMIER. The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination. Nucleic acids research. Oxford: Oxford University Press, 2021, vol. 49, No 11, p. 6529-6548. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkab436.

MARKOVÁ, Klára, Klaudia CHMELOVÁ, Sérgio Manuel MARQUES, Philippe CARPENTIER, David BEDNÁŘ, Jiří DAMBORSKÝ and Martin MAREK. Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst. Chemical Science. Cambridge: Royal Society of Chemistry, 2020, vol. 11, No 41, p. 11162-11178. ISSN 2041-6520. Available from: https://dx.doi.org/10.1039/d0sc03367g.

MAREK, Martin, Radka CHALOUPKOVÁ, Tanyana PRUDNIKOVA, Yukari SATO, Pavlina REZACOVA, Yuji NAGATA, Ivana SMATANOVA KUTA and Jiří DAMBORSKÝ. Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family. Computational and Structural Biotechnology Journal. Amsterdam: Elsevier, 2020, vol. 18, December 2020, p. 1352-1362. ISSN 2001-0370. Available from: https://dx.doi.org/10.1016/j.csbj.2020.05.019.

BABKOVÁ, Petra, Zuzana DUNAJOVÁ, Radka CHALOUPKOVÁ, Jiří DAMBORSKÝ, David BEDNÁŘ and Martin MAREK. Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics. Computational and Structural Biotechnology Journal. Amsterdam: Elsevier, 2020, vol. 18, No 2020, p. 1497-1508. ISSN 2001-0370. Available from: https://dx.doi.org/10.1016/j.csbj.2020.06.021.

ŠTOURAČ, Jan, O. VAVRA, Piia Pauliina KOKKONEN, Jiří FILIPOVIČ, Gabriela Filipa FONSECA PINTO, Andrea SCHENKMAYEROVÁ, Jiří DAMBORSKÝ and David BEDNÁŘ. Caver web: identification of tunnels and channels in proteins and analysis of ligand transport. In European Biotechnology Congress. 2019. ISSN 0168-1656. Available from: https://dx.doi.org/10.1016/j.jbiotec.2019.05.251.

SCHENKMAYEROVA, A., G. PINTO, Martin MAREK, Martin TOUL, Lenka HERNYCHOVÁ, Veronika LIŠKOVÁ, S. EMOND, David BEDNÁŘ, Zbyněk PROKOP, Radka CHALOUPKOVÁ, F. HOLLFELDER and U.T. BORNSCHEUER. Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor. In European Biotechnology Congress. 2019. ISSN 0168-1656. Available from: https://dx.doi.org/10.1016/j.jbiotec.2019.05.118.

CHALOUPKOVÁ, Radka, Veronika LIŠKOVÁ, Martin TOUL, Klára MARKOVÁ, Eva ŠEBESTOVÁ, Lenka HERNYCHOVÁ, Martin MAREK, José Gaspar RANGEL PAMPLONA PIZARRO PINTO, Daniel PLUSKAL, Jitka WATERMAN, Zbyněk PROKOP and Jiří DAMBORSKÝ. Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts. ACS Catalysis. Washington, D.C.: AMER CHEMICAL SOC, 2019, vol. 9, No 6, p. 4810-4823. ISSN 2155-5435. Available from: https://dx.doi.org/10.1021/acscatal.9b01031.

ZESSIN, M., Z. KUTIL, M. MELESHIN, Z. NOVAKOVA, E. GHAZY, D. KALBAS, Martin MAREK, C. ROMIER, W. SIPPL, C. BARINKA and M. SCHUTKOWSKI. One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry. Washington: American Chemical Society, 2019, vol. 58, No 48, p. 4777-4789. ISSN 0006-2960. Available from: https://dx.doi.org/10.1021/acs.biochem.9b00786.

SIMOBEN, Conrad V., Dina ROBAA, Alokta CHAKRABARTI, Karin SCHMIDTKUNZ, Martin MAREK, Julien LANCELOT, Srinivasaraghavan KANNAN, Jelena MELESINA, Tajith B. SHAIK, Raymond J. PIERCE, Christophe ROMIER, Manfred JUNG and Wolfgang SIPPL. A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules. BASEL: Mayer und Muller, 2018, vol. 23, No 3, p. 1-14. ISSN 1420-3049. Available from: https://dx.doi.org/10.3390/molecules23030566.

MAREK, Martin, Tajith B. SHAIK, Tino HEIMBURG, Alokta CHAKRABARTI, Julien LANCELOT, Elizabeth RAMOS-MORALES, Cyrielle DA VEIGA, Dmitrii KALININ, Jelena MELESINA, Dina ROBAA, Karin SCHMIDTKUNZ, Takayoshi SUZUKI, Ralph HOLL, Eric ENNIFAR, Raymond J. PIERCE, Manfred JUNG, Wolfgang SIPPL and Christophe ROMIER. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. Journal of Medicinal Chemistry. Washington: American Chemical Society, 2018, vol. 61, No 22, p. 10000-10016. ISSN 0022-2623. Available from: https://dx.doi.org/10.1021/acs.jmedchem.8b01087.

LECOINTRE, Bertrand, Remy NAROZNY, Maria Teresa BORRELLO, Johanna SENGER, Alokta CHAKRABARTI, Manfred JUNG, Martin MAREK, Christophe ROMIER, Jelena MELESINA, Wolfgang SIPPL, Laurent BISCHOFF and A. GANESAN. Isoform-selective HDAC1/16/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. LONDON: ROYAL SOC, 2018, vol. 373, No 1748, p. 1-7. ISSN 0962-8436. Available from: https://dx.doi.org/10.1098/rstb.2017.0364.