Publication Records

JAUREGUI, Gretsen Velezmoro, Dragana VUKIĆ, Isaac G ONYANGO, Carlos ARIAS, Jan S NOVOTNY, Katerina TEXLOVA, Shanshan WANG, Kristina Locker KOVACOVICOVA, Natalie POLAKOVA, Jana ZELINKOVA, Maria CARNA, Valentina LACOVICH STRAŠIL, Brian P HEAD, Daniel HAVAS, Martin MISTRIK, Robert ZOREC, Alexei VERKHRATSKY, Liam KEEGAN, Mary Anne O'CONNELL, Robert RISSMAN and Gorazd B STOKIN. Amyloid precursor protein induces reactive astrogliosis. Acta Physiologica. Hoboken: Wiley, 2024, vol. 240, No 6, p. 1-17. ISSN 1748-1708. Available from: https://dx.doi.org/10.1111/apha.14142.

SINIGAGLIA, Ketty, Anna CHERIAN, Qiupei DU, Valentina LACOVICH STRAŠIL, Dragana VUKIĆ, Janka MELICHEROVÁ, Pavla MUSILOVÁ, Lisa ZERAD, Stanislav STEJSKAL, Radek MALIK, Jan PROCHAZKA, Nadege BONDURAND, Radislav SEDLACEK, Mary Anne O'CONNELL and Liam KEEGAN. An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation. Cell Reports. CAMBRIDGE: Cell Press, 2024, vol. 43, No 8, p. 1-25. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2024.114618.

KEEGAN, Liam, Khadija HAJJI and Mary Anne O'CONNELL. Adenosine Deaminase Acting on RNA (ADAR) Enzymes: A Journey from Weird to Wondrous. Accounts of chemical research. WASHINGTON: American Chemical Society, 2023, vol. 56, No 22, p. 3165-3174. ISSN 0001-4842. Available from: https://dx.doi.org/10.1021/acs.accounts.3c00433.

O'CONNELL, Mary Anne, Michaela MUSILOVÁ and Barbora TRUKSOVÁ. RNA PhD Conference 2023. 2023.

HAJJI, Khadija, Jiří SEDMÍK, Anna CHERIAN, Damiano AMORUSO, Liam KEEGAN and Mary Anne O'CONNELL. ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations. RNA. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2022, vol. 28, No 10, p. 1281-1297. ISSN 1355-8382. Available from: https://dx.doi.org/10.1261/rna.079266.122.

LASAVICIUTE, Gintare, Myriam BARZ, van der Heiden MARIEKE, Claudia ARASA, Kanwal TARIQ, Jaclyn Elizabeth QUIN, Ostlund Farrants ANN-KRISTIN and Eva SVERREMARK-EKSTROM. Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro. GUT MICROBES. UNITED STATES: TAYLOR & FRANCIS INC, 2022, vol. 14, No 1, p. 2045046-2045061. ISSN 1949-0976. Available from: https://dx.doi.org/10.1080/19490976.2022.2045046.

MARTINO, Fabiana, Nandan Mysore VARADARAJAN, Ana Rubina PERESTRELO, Václav HEJRET, Helena DURIKOVA, Dragana VUKIĆ, Vladimir HORVATH, Francesca CAVALIERI, Frank CARUSO, Waleed S ALBIHLAL, Andre P GERBER, Mary Anne O'CONNELL, Štěpánka VAŇÁČOVÁ, Stefania PAGLIARI and Giancarlo FORTE. The mechanical regulation of RNA binding protein hnRNPC in the failing heart. Science Translational Medicine. Washington: American Association for the Advancement of Science, 2022, vol. 14, No 672, p. 1-17. ISSN 1946-6234. Available from: https://dx.doi.org/10.1126/scitranslmed.abo5715.

QUIN, Jaclyn Elizabeth, Jiří SEDMÍK, Dragana VUKIĆ, Anzer KHAN, Liam KEEGAN and Mary Anne O'CONNELL. ADAR RNA Modifications, the Epitranscriptome and Innate Immunity. Trends in Biochemical Sciences. Cambridge (MA): Cell Press, 2021, vol. 46, No 9, p. 758-771. ISSN 0968-0004. Available from: https://dx.doi.org/10.1016/j.tibs.2021.02.002.

MAROOFIAN, Reza, Jiří SEDMÍK, Neda MAZAHERI, Marcello SCALA, Maha S. ZAKI, Liam KEEGAN, Reza AZIZIMALAMIRI, Mahmoud ISSA, Gholamreza SHARIATI, Alireza SEDAGHAT, Christian BEETZ, Peter BAUER, Hamid GALEHDARI, Mary Anne O'CONNELL and Henry HOULDEN. Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy. Journal of Medical Genetics. London (UK): BMJ Publishing Group, 2021, vol. 58, No 7, p. 495-504. ISSN 0022-2593. Available from: https://dx.doi.org/10.1136/jmedgenet-2020-107048.

O'CONNELL, Mary. Generation of stable cell lines for the screening of inhibitors of the ADAR enzymes. Masarykova univerzita, 2021.

FEDOROVÁ, Veronika, Tereza VÁŇOVÁ, Veronika POSPÍŠILOVÁ, Jan RAŠKA, Jiří SEDMÍK, Simona VOCHYÁNOVÁ, Hana HŘÍBKOVÁ and Dáša BOHAČIAKOVÁ. Glioblastom a cerebrální organoidy: zavedení a analýza in vitro modelu. In XXIV. Biologické dny 2021, Brno, 6.-7. 9. 2021. 2021.

RENGARAJ, Praveenkumar, Aleš OBRDLÍK, Dragana VUKIĆ, Nandan Mysore VARADARAJAN, Liam KEEGAN, Štěpánka VAŇÁČOVÁ and Mary Anne O'CONNELL. Interplays of different types of epitranscriptomic mRNA modifications. RNA Biology. Philadelphia: Taylor & Francis Inc, 2021, vol. 18, S1, p. 19-30. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2021.1969113.

KURKOWIAK, M., L. ARCIMOWICZ, E. CHRUSCIEL, Z. URBAN-WOJCIUK, I. PAPAK, Liam KEEGAN, Mary Anne O'CONNELL, J. KOWALSKI, T. HUPP and N. MAREK-TRZONKOWSKA. The effects of RNA editing in cancer tissue at different stages in carcinogenesis. RNA Biology. Philadelphia: Taylor & Francis Inc, 2021, vol. 18, No 11, p. 1524-1539. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2021.1877024.

DENG, Patricia, Anzer KHAN, Dionna JACOBSON, Nagraj SAMBRANI, Leeanne MCGURK, Xianghua LI, Aswathy JAYASREE, Jan HEJÁTKO, Galit SHOHAT-OPHIR, Mary Anne O'CONNELL, Jin Billy LI and Liam KEEGAN. Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila. Nature Communications. London: Nature Publishing Group, 2020, vol. 11, No 1, p. 1-13. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-020-15435-1.

TAN, Tiong Yang, Jiří SEDMÍK, Mark P. FITZGERALD, Rivka SUKENIK HALEVY, Liam KEEGAN, Ingo HELBIG, Lina BASEL-SALMON, Lior COHEN, Rachel STRAUSSBERG, Wendy K. CHUNG, Mayada HELAL, Reza MAROOFIAN, Henry HOULDEN, Jane JUUSOLA, Simon SADEDIN, Lynn PAIS, Katherine B. HOWELL, Susan M. WHITE, John CHRISTODOULOU and Mary Anne O'CONNELL. Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures. The American Journal of Human Genetics. University of Chicago Press for the American Society of Human Genetics, 2020, vol. 106, No 4, p. 467-483. ISSN 0002-9297. Available from: https://dx.doi.org/10.1016/j.ajhg.2020.02.015.

SINIGAGLIA, Ketty, Janka MELICHEROVÁ, Stanislav STEJSKAL, Liam KEEGAN and Mary Anne O'CONNELL. Elucidating the Biological Role of ADAR1 in the Innate immunity Response. In CEITEC PhD Conference. 2020.

KHAN, Anzer, Simona PARO, Leeanne MCGURK, Nagraj SAMBRANI, Marion C. HOGG, James Paul BRINDLE, Giuseppa PENNETTA, Liam KEEGAN and Mary Anne O'CONNELL. Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy. BMC Biology. London: BMC, 2020, vol. 18, No 1, p. 1-16. ISSN 1741-7007. Available from: https://dx.doi.org/10.1186/s12915-020-0747-0.

PISKÁČEK, Martin, Marek HAVELKA, Kristína JENDRUCHOVÁ, Andrea KNIGHT and Liam KEEGAN. The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. Cellular and molecular life sciences. BASEL: BIRKHAUSER VERLAG AG, 2020, vol. 77, No 9, p. 1793-1810. ISSN 1420-682X. Available from: https://dx.doi.org/10.1007/s00018-019-03251-w.

TROYE-BLOMBERG, M., C. ARAMA, Jaclyn Elizabeth QUIN, I. BUJILA and A.K.O. FARRANTS. What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria? Scandinavian journal of immunology. HOBOKEN: WILEY, 2020, vol. 92, No 4, p. 12932-12938. ISSN 0300-9475. Available from: https://dx.doi.org/10.1111/sji.12932.

WIATREK-MOUMOULIDIS, Dagmara Marta, Maria Elena CANDELA, Jiří SEDMÍK, Jan OPPELT, Liam KEEGAN and Mary Anne O'CONNELL. Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein. RNA. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2019, vol. 25, No 6, p. 713-726. ISSN 1355-8382. Available from: https://dx.doi.org/10.1261/rna.069625.118.

SINIGAGLIA, Ketty, Dagmara WIATREK, Anzer KHAN, David MICHALÍK, Nagraj SAMBRANI, Jiří SEDMÍK, Dragana VUKIĆ, Mary Anne O'CONNELL and Liam KEEGAN. ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep. Biochimica et biophysica acta - Gene regulatory mechanisms. Amsterdam: Elsevier, 2019, vol. 1862, No 3, p. 356-369. ISSN 1874-9399. Available from: https://dx.doi.org/10.1016/j.bbagrm.2018.10.011.

JAMBOROVÁ, Ivana, Nicol JANECKO, Dana HÁLOVÁ, Jiří SEDMÍK, Kristýna MEZEROVÁ, Ivo PAPOUŠEK, Iva KUTILOVÁ, Monika DOLEJSKÁ, Alois ČÍŽEK and Ivan LITERÁK. Molecular characterization of plasmid-mediated AmpC beta-lactamase- and extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae among corvids (Corvus brachyrhynchos and Corvus corax) roosting in Canada. FEMS Microbiology Ecology. Oxford, England: Oxford University Press, 2018, Volume 94, Issue 11. ISSN 0168-6496. Available from: https://dx.doi.org/10.1093/femsec/fiy166.

O'CONNELL, Mary Anne. Nucleic Acids, Immunity and Genome Defence. 2018.

JANTSCH, M.F., A. QUATTRONE, Mary Anne O'CONNELL, M. HELM, M. FRYE, M. MACIAS-GONZALES, M. OHMAN, S. AMERES, L. WILLEMS, F. FUKS, A. OULAS, Štěpánka VAŇÁČOVÁ, H. NIELSEN, C. BOUSQUET-ANTONELLI, Y. MOTORIN, J.Y. ROIGNANT, N. BALATSOS, A. DINNYES, P. BARANOV, V. KELLY, A. LAMM, G. RECHAVI, M. PELIZZOLA, J. LIEPINS, I.H. KHOLODNYUK, V. ZAMMIT, D. AYERS, F. DRABLOS, J.A. DAHL, J. BUJNICKI, C. JERONIMO, R. ALMEIDA, M. NEAGU, M. COSTACHE, J. BANKOVIC, B. BANOVIC, J. KYSELOVIC, L.M. VALOR, S. SELBERT, P. PIR, T. DEMIRCAN, V. COWLING, M. SCHAFER, W. ROSSMANITH, D. LAFONTAINE, A. DAVID, C. CARRE, F. LYKO, R. SCHAFFRATH, S. SCHWARTZ, A. VERDEL, A. KLUNGLAND, E. PURTA, G. TIMOTIJEVIC, F. CARDONA, A. DAVALOS, E. BALLANA, D. O CARROLL, J. ULE and R. FRAY. Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA BIOLOGY. PHILADELPHIA: TAYLOR & FRANCIS INC, 2018, vol. 15, No 6, p. 829-831. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2018.1460996.

BAJAD, P., MF JANTSCH, Liam KEEGAN and Mary Anne O'CONNELL. A to I editing in disease is not fake news. RNA BIOLOGY. PHILADELPHIA: TAYLOR & FRANCIS INC, 2017, vol. 14, No 9, p. 1223-1231. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2017.1306173.

KEEGAN, Liam, Anzer KHAN, Dragana VUKIĆ and Mary O'CONNELL. ADAR RNA editing below the backbone. RNA. COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2017, vol. 23, No 9, p. 1317-1328. ISSN 1355-8382. Available from: https://dx.doi.org/10.1261/rna.060921.

GALLO, Angela, Dragana VUKIĆ, David MICHALÍK, Mary O'CONNELL and Liam KEEGAN. ADAR RNA editing in human disease; more to it than meets the I. Human Genetics. NEW YORK: SPRINGER, 2017, vol. 136, No 9, p. 1265-1278. ISSN 0340-6717. Available from: https://dx.doi.org/10.1007/s00439-017-1837-0.

TAN, M.H., Q. LI, R. SHANMUGAM, R. PISKOL, J. KOHLER, A.N. YOUNG, K.I. LIU, R. ZHANG, G.R. AMASWAMI, K. ARIYOSHI, A. GUPTE, Liam KEEGAN, C.X. GEORGE, A.R. AMU, N. HUANG, E.A. POLLINA, D.S. LEEMAN, A.R. USTIGHI, Y.P.S. GOH, A.C. HAWLA, Sal G. DEL, G. PELTZ, A.B. RUNET, D.F.C. ONRAD, C.E. SAMUEL, Mary Anne O'CONNELL, C.R. WALKLEY, K. NISHIKURA and J.B. LI. Dynamic landscape and regulation of RNA editing in mammals. Nature. LONDON: NATURE PUBLISHING GROUP, 2017, vol. 550, No 7675, p. 249-272. ISSN 0028-0836. Available from: https://dx.doi.org/10.1038/nature24041.

SAMPELS, S., H.K. KROUPOVA and Pavla LINHARTOVÁ. Effect of cadmium on uptake of iron, zinc and copper and mRNA expression of metallothioneins in HepG2 cells in vitro. Toxicology in vitro. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol. 44, OCT, p. 372-376. ISSN 0887-2333. Available from: https://dx.doi.org/10.1016/j.tiv.2017.08.003.

QUIN, J.E., I. BUJILA, M. CHERIF, G.S. SANOU, Y. QU, MV HOMANN, A. ROLICKA, S.B. SIRIMA, Mary Anne O'CONNELL, A. LENNARTSSON, M. TROYE-BLOMBERG, I. NEBIE and A.K.O. FARRANT. Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria. elife. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2017, vol. 6, SEP, p. nestránkováno, 19 pp. ISSN 2050-084X. Available from: https://dx.doi.org/10.7554/eLife.29156.

MONFORT, Asun, Giulio DI MININ, Andreas POSTLMAYR, R. FREIMANN, Fabiana ARIETI, Stéphane THORE and Anton WUTZ. Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells. Cell Reports. CAMBRIDGE: Cell Press, 2015, vol. 12, No 4, p. 554-561. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2015.06.067.

MANNION, Niamh, Fabiana ARIETI, Angela GALLO, Liam KEEGAN and Mary O´CONNELL. New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins. Biomolecules. Basel, Switzerland: MDPI AG, 2015, vol. 5, No 4, p. 2338-2362. ISSN 2218-273X. Available from: https://dx.doi.org/10.3390/biom5042338.

O´CONNELL, Mary. RNA modification and the epitranscriptome; the next frontier. RNA. New York: Cold Spring Harbor Laboratory Press, 2015, vol. 21, No 4, p. 703-704. ISSN 1355-8382. Available from: https://dx.doi.org/10.1261/rna.050260.115.

O´CONNELL, Mary, Niamh M. MANNION and Liam KEEGAN. The Epitranscriptome and Innate Immunity. PLOS GENETICS. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2015, vol. 11, No 12, p. 1-11. ISSN 1553-7404. Available from: https://dx.doi.org/10.1371/journal.pgen.1005687.