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Vybrané publikace/výsledky

Accurate Reduced Spectral Density Mapping for Analysis of 13C Relaxation Rates (2012)
Influence of the O-phosphorylation of serine, threonine and tyrosine in proteins on the amidic N-15 chemical shielding anisotropy tensors (2013)
Expression of FGF19 in Human Embryonic Stem Cells (2013)
High-Resolution Insight into G-Overhang Architecture (2013)
Triplex intermediates in folding of human telomeric quadruplexes probed by microsecond-scale molecular dynamics simulations (2014)
In-Cell NMR and EPR Spectroscopy of Biomacromolecules (2014)
Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 (2014)
MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME (2014)
Loss of loop adenines alters human telomere d(AG3(TTAG3)3) quadruplex folding (2014)
The activation of N-glycosidic bond cleavage performed by base-excision repair enzyme hOGG1; theoretical study of the role of Lys 249 residue in activation of G, OxoG and FapyG (2014)
Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA (2015)
Instability restricts signaling of multiple fibroblast growth factors (2015)
A novel variant of FGFR3 causes proportionate short stature (2015)
Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex (2015)
Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin–spin interactions (2016)
Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations (2015)
FGF19/BETA-KLOTHO REGULATE PHYSIOLOGY AND DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS (2014)
Ceremonial inauguration of the "Josef Dadok National NMR Centre" (2013)
Lithium increases proliferation of hippocampal neural stem/progenitor cells and rescues irradiation-induced cell cycle arrest in vitro (2015)
Expression and Subcellular Distribution of GFP-Tagged Human Tetraspanin Proteins in Saccharomyces cerevisiae (2015)
Spectral density mapping at multiple magnetic fields suitable for C-13 NMR relaxation studies (2016)
Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission (2016)
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome (2016)
Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma (2017)
Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution (2016)
Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle (2016)
ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner (2016)
One reporter for in-cell activity profiling of majority of protein kinase oncogenes (2017)
Structure of a Stable G-Hairpin (2017)
Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes (2017)
KSR proteins link metabolic changes to the MAPK/ERK pathway (2016)
Modulation of melanoma metabolism and viability with hexokinase and mitochondrial complex I inhibitors (2014)
Characterization of Non-B DNA structures in complex environment of mammalian cells by in cell NMR spectroscopy (2017)
Monitoring DNA-ligand interactions using in cell NMR spectroscopy (2017)
Cellular structural biology of nucleic acids (2017)
Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480 (2017)
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells (2017)
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses (2017)
Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization (2018)
Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells (2018)
G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression (2017)
Structure-activity relationships in polymorphic G-quadruplex forming segment of c-MYC promoter (2017)
Systematic analysis of BCR-ABL interactome in chronic myeloid leukemia (2017)
i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions (2018)
Protonation of nucleobases in single- and double-stranded DNA (2018)
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling (2018)
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases (2018)
Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals (2018)
Analysis of binding interfaces of the human scaffold protein AXIN1 by peptide microarrays (2018)
Advances in the cellular structural biology of nucleic acids (2018)
NMR spectroscopy of nucleic acids in human cells (2018)
Multivalency regulates activity in an intrinsically disordered transcription factor (2018)
Gold nanoparticles as labels for immunochemical analysis using laser ablation inductively coupled plasma mass spectrometry (2019)
Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1 (2019)
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase (2019)
Electrochemical and Spectral Analysis of Cytosine-rich Nonamers (2019)
Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy (2019)
Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs (2019)
Human retinal organoids as a tool for investigation of circadian rhythms. (2019)
Multicolor Immunophenotyping of Candidate Leukemic Stem Cell Markers in CD34+CD38- Chronic Myeloid Leukemia Stem Cells. (2019)
Analysis of gene expression in CD26+ CML leukemic stem cell population. (2019)
Parallel G-triplexes and G-hairpins as potential transitory ensembles in the folding of parallel-stranded DNA G-Quadruplexes (2019)
Role zánětu v etiopatogenezi farmakorezistentní epilepsie a refrakterního status epilepticus. (2020)
Systematic investigation of sequence requirements for DNA i-motif formation (2019)
CdS quantum dots-based immunoassay combined with particle imprinted polymer technology and laser ablation ICP-MS as a versatile tool for protein detection (2019)
Molecularly imprinted polymers coupled to mass spectrometric detection for metallothionein sensing (2019)
In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures Inside Living Xenopus laevis Oocytes (2019)
In-Cell NMR Spectroscopy of Nucleic Acids in Human Cells (2019)
NMR STUDY OF d(CCCGAGA) i-MOTIF STRUCTURE (2017)
Clonal hierarchy of main molecular lesions in acute myeloid leukaemia (2020)
Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia (2020)
Composite 5-methylations of cytosines modulate i-motif stability in a sequence-specific manner: Implications for DNA nanotechnology and epigenetic regulation of plant telomeric DNA (2020)
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds (2020)
Low Density Lipoprotein Receptor Variants in the Beta-Propeller Subdomain and Their Functional Impact (2020)
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex (2020)
miR-183/96/182 cluster is an important morphogenetic factor targetingPAX6expression in differentiating human retinal organoids (2020)
Multicolor immuno-phenotyping of candidate leukemic stem cell markers in CD34+CD38- chronic myeloid leukemia stem cells. (2020)
Role of folding kinetics of secondary structures in telomeric G-overhangs in the regulation of telomere maintenance inSaccharomyces cerevisiae (2020)
In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells (2021)
HERMES - A Software Tool for the Prediction and Analysis of Magnetic-Field-Induced Residual Dipolar Couplings in Nucleic Acids (2020)
LA-ICP-MS as a sensitive method for detection of nanoparticle-antibody conjugates in immunochemistry analysis (2019)
Development of novel patient-derived xenograft model of chronic lymphocytic leukemia. (2020)
Možnosti imunomodulační terapie epilepsií. (2020)
HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment (2020)
Structure of a DNA G-Quadruplex Related to Osteoporosis with a G-A Bulge Forming a Pseudo-loop (2020)
In-cell NMR Spectroscopy of Nucleic Acids (2020)
Thermal and pH stabilities of i‐DNA: confronting in vitro experiments with models and in‐cell NMR data (2021)
Hierarchical distribution of somatic variants in newly diagnosed chronic myeloid leukaemia at diagnosis and early follow-up (2021)
GAB1 Regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia: novel therapeutic target (2021)
In vivo antigen-negative escape to CART-19 caused by CD19 promotor hypermethylation. (2021)
Palbociclib and ponatinib induce regression of acute myeloid leukemia in patient-derived xenograft model. (2021)
Detekce transpozibilních elementů u hematologických malignit. (2021)
GAB1 reguluje tonickou AKT signalizaci a migraci buněk chronické lymfatické leukémie: implikace pro kombinační léčbu s BCR inhibitory. (2021)
Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro (2021)
FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia (2021)
Disruption of NAP1 genes in Arabidopsis thaliana suppresses the fas1 mutant phenotype, enhances genome stability and changes chromatin compaction (2021)
FoxO1-GAB1 Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia: Novel Therapeutic Target. (2021)
GAB1 – novel regulator of migration capacity and tonic AKT activity in CLL: Implications for combinatorial therapy with BCR inhibitors. (2021)
Patient-derived Xenograft Model of Chronic Lymphocytic Leukaemia Based on Mimicking Its Microenvironment. (2021)
Acute myeloid leukemia regression induced by palbociclib and ponatinib in patient –derived xenograft model. (2021)
Insight into formation propensity of pseudocircular DNA G-hairpins (2021)
G-Quadruplex Formation by DNA Sequences Deficient in Guanines: Two Tetrad Parallel Quadruplexes Do Not Fold Intramolecularly (2021)
Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy (2021)
Optimization of plasma-activated media generation for decontamination of thermally sensitive materials (2022)
Nanoparticles as tags for protein tissue analysis using laser ablation inductively coupled plasma and mass spectrometry (2019)
Sekvenování dlouhých nekódujících RNA v exozomech u pacientů s kolorektálním karcinomem (2022)
Versatile coculture systém to study chronic lymhocytic leukemia proliferation. (2022)
Bio-dekontaminačná komora na báze plazmou aktivovaného dekontaminačného média (2022)
GAB1 as novel therapeutic target in B lymphoid and myeloid malignancies (2022)
Polymorphic and Higher-Order G-Quadruplexes as Possible Transcription Regulators: Novel Perspectives for Future Anticancer Therapeutic Applications (2022)
Spinal Metastasis in a Patient with Supratentorial Glioblastoma with Primitive Neuronal Component: A Case Report with Clinical and Molecular Evaluation (2023)
Acute myeloid leukemia suppression by palbociclib and ponatinib in patient-derived xenograft. (2023)
Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy (2022)
Characterisation of Macrophage Response to Nickel Nanoparticles and Ions Released from Biomaterials (2023)
Domain 1.1 of σA factor of RNA polymerase from Bacillus subtilis beyond its major state conformation (2023)
Small RNA Sequencing Identifies a Six-MicroRNA Signature Enabling Classification of Brain Metastases According to their Origin (2023)
Characterization of a transitionally occupied state and thermal unfolding of domain 1.1 of σ A factor of RNA polymerase from Bacillus subtilis (2023)
CCL2/MCP-1, interleukin-8, and fractalkine/CXC3CL1: Potential biomarkers of epileptogenesis and pharmacoresistance in childhood epilepsy (2023)
DNA i-motif formation at neutral pH is driven by kinetic partitioning (2023)
Nanodiamonds as artificial proteins for regulation of a cell signalling system (2023)
Characterisation of invisible conformation of domain 1.1 of σA factor of RNA polymerase from Bacillus subtilis (2023)
The role of casein kinase 1 inhibition in treatment of chronic lymphocytic leukemia. (2023)
Biomaterial selection does not affect AML engraftment in humanized ossicles. (2023)
A thermosensitive gel matrix for bioreactor-assisted in-cell NMR of nucleic acids and proteins (2023)
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase (2023)
Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genomewide CRISPR screening. (2023)
Genome-wide CRISPR/Cas9 knockout screening revealed genes involved in CD20 regulation. (2023)
Genome-wide CRISPR/Cas9 knockout screening revealed genes involved in CD20 regulation in rituximab-resistant cells. (2023)
Coculture model with CD40L, IL4 and IL21 for study chronic lymphocytic leukemia proliferation. (2023)
Inhibition of acute myeloid leukemia using palbociclib and ponatinib in a patient-derived xenograft model. (2023)
Nanodiamonds as artificial proteins for regulation of a cell signalling system (2023)
A sodium/potassium switch for G4-prone G/C-rich sequences (2024)
Functional analysis of LDLR variants using flow cytometry (2023)
Functional analysis of LDLR variants using flow cytometry and western blot (2023)
Detailed insight into dynamics of C-terminal domain of δ subunit of RNA polymerase from Bacillus subtilis using high-resolution relaxometry (2023)
Detailed insight into dynamics of intrinsically disordered proteins using high-resolution relaxometry (2023)
Study of the Dynamics of Flexible Subunits of RNA Polymerase from Bacillus subtilis (2023)
In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells (2024)
Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions (2024)
Tumor tissue and cerebrospinal fluid microRNA profiles enable the classification of brain metastasis accordingly to their origin (2023)

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