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Publications Publication Records - Search Tato aplikace je zatím určena pro spuštění na stolním počítači. Na tomto mobilním zařízení je také funkční, ale zatím plně nevyužívá jeho možností.

Tato aplikace je zatím určena pro spuštění na stolním počítači. Na tomto mobilním zařízení je také funkční, ale zatím plně nevyužívá jeho možností.

Publication Records - Search

Selected publication/outcome records

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing (2018)
Identification of new endocrine disruptive transthyretin ligands in polluted waters using pull-down assay coupled to non-target mass spectrometry (2024)
Isoform-selective HDAC1/16/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity (2018)
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts (2019)
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity (2019)
Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor (2019)
Caver web: identification of tunnels and channels in proteins and analysis of ligand transport (2019)
Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst (2020)
Multi-pathogen infections and Alzheimer's disease (2021)
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics (2020)
Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family (2020)
Engineering the protein dynamics of an ancestral luciferase (2021)
The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination (2021)
Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers (2021)
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2 (2021)
Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi (2021)
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin (2022)
Tools for computational design and high-throughput screening of therapeutic enzymes (2022)
Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase (2022)
Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase (2021)
Computational enzyme design for metabolic engineering (2021)
Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling (2022)
PredictSNP Onco 1.0 (2022)
Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease (2022)
Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase (2022)
Catalytic mechanism for Renilla-type luciferases (2023)
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate (2023)
Identification, characterization, and engineering of glycosylation in thrombolytics (2023)
Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues (2023)
Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning (2023)
In cellulo and in vivo assays for compound testing against Trypanosoma cruzi (2023)
Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography (2023)
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum (2023)
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase (2023)
Study of Protein Conformational Dynamics Using Hydrogen/Deuterium Exchange Mass Spectrometry (2023)
N-glycan profiling of tissue samples to aid breast cancer subtyping (2024)
Changes of serum protein N-glycosylation in cancer (2022)
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants (2018)

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