Vyhledávání publikací

Vybrané publikace/výsledky

Screeningové hodnocení environmentálních rizik v sedimentech regionu Zlín (2000)
Hodnocení biodostupnosti organických látek půdním mikroorganismům kontaktními testy toxicity (2000)
The use of a microbial contact toxicity test for evaluating cadmium bioavailability in soil (2001)
Bioavailability and mobility of organic contaminants in soil and sediment samples: a three-step ecotoxicology evaluation (2001)
Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product and water mediated inhibition (2002)
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis (2002)
Re-construction of mycobacterial dehalogenase Rv2579 by cumulative mutagenesis of haloalkane dehalogenase LinB (2003)
Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates (2003)
Catalytic mechanism of the haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 (2003)
Validation of Putative Enzymes from Genomic Projects: Confirmation of Dehalogenation ARv2ctivity for Mycobacterial Protein 579 (2003)
Modification of Activity and Specificity of Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26 by Engineering of its Entrance Tunnel (2003)
Mobility, bioavailability and toxic effects of cadmium in soil samples. (2003)
Substrátová specifita haloalkandehalogenáz (2004)
Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26. (2005)
Development of a microtiter plate-based method for determination of degradation profile of nitrophenolic compounds (2006)
Two Rhizobial Strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, Encode Haloalkane Dehalogenases with Novel Structures and Substrate Specificities (2005)
Mycobacterial Haloalkane Dehalogenases: Cloning, Biochemical Properties and distribution. (2005)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2005)
Způsob detoxikace sulfidického yperitu psobením halogenalkandehalogenázami (2005)
Vývoj enzymového biosenzoru pro detekci chlorovaných pesticidů (2005)
Navržení Biosenzoru pro detekci chlorovaných pesticidů (2006)
Elektrochemické stanovení chloridů na uhlíkových elektrodách (2006)
Enzymový Biosenzor pro detekci chlorovaných pesticidů (2006)
Analýza chlorovaných uhlovodíků s využitím stříbrné a uhlíkové pastové elektrody (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides (2006)
Vyvoj enzymoveho biosenzoru pro detekci chlorovanych pesticidu (2006)
High-throughput characterization of enzymes from genomic and proteomic projects-multivariate statistical approach (2006)
Protein engineering of haloalkane dehalogenase LinB: reconstruction of active site and modification of entrance tunnel (2006)
Expression of Glycosylated Haloalkane Dehalogenase LinB in Pichia pastoris. (2006)
Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. (2007)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2006)
Enzymes Fight Chemicals Weapons. (2006)
Development of biosensor for determination of chlorinated pesticides. (2006)
Engineering of enantioselective enzyme by cumulative mutagenesis. (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides. (2006)
Solvent Isotope Effects on Haloalkane Dehalogenase LinB. (2006)
Physical Variables as a Control of Enzyme Stereoselectivity (2006)
Engineering of Enantioselective Haloalkane Dehalogenase by Cumulative Mutagenesis (2006)
Discovery of Stereoselective Haloalkane Dehalogenases: New Tool for Asymmetric Syntheses. (2006)
Expression of Haloalkane Dehalogenase LinB in Pichia pastoris (2006)
Development of Enzymatic Biosensor for Determination of Chlorinated Pesticides (2006)
Řízení stereoselektivity enzymu fyzikálně-chemickými parametry (2006)
Natural and Engineered Enantioselective Haloalkane Dehalogenases (2006)
Structure-Based Engineering of Haloalkane Dehalogenase (2006)
Engineering of Haloalkane Dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 Towards Higher Enantioselectivity (2006)
The stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of Temperature and pH (2006)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2007)
Characterization of Haloalkane Dehalogenases DrbA and DmbC: Representatives of Novel Subfamily. (2009)
Degradation of Beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Hexachlorocyclohexane-Utilizing Bacterium Sphingobium sp. MI1205 (2007)
Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-ray Crystallography and Microcalorimetry (2007)
Degradation of 4 Nitroguaiacol and Other Nitroaromatic Compounds by Strains of Arthrobacter nitroguajacolicus. (2007)
Enzymatic reaction coupled with flow-injection analysis with charged aerosol, coulometric, or amperometric detection for estimation of contamination of the environment by pesticides (2008)
Degradation of 4 Nitroguaiacol and Other Nitroaromatic Compounds by Strains of Arthrobacter nitroguajacolicus. (2008)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The effect of temperature and pH (2007)
Haloalkane Dehalogenases Possess Two Different Structural Bases for Their Enantioselectivity (2007)
Comparative Binding Energy (COMBINE) Analysis of the Substrate Specificity of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110. (2007)
Keyhole-Lock-Key Model of Enzymatic Catalysis: Engineering of Tunnels in Proteins with Buried Active Sites (2007)
Změna enantioselektivity a substrátové specifity haloalkan dehalogenázy proteinovým inženýrstvím (2007)
Comparative Binding Energy Analysis of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110 (2007)
Development of Enzymatic Biosensors for Detection of Halogenated Environmental Pollutants (2007)
Stereoselektivita a konformační stabilita halogenalkan dehalogenázy DbjA z Bradyrhizobium japonicum USDA110, (2007)
Využití enzymů ve farmaceutických výrobách (2007)
Enzymatic Detoxification of Sulfur Mustard by Haloalkane Dehalogenases (2007)
LinB Enzyme for Detection of Chlorinated Pesticides- Suggestion Design of a New Biosensor (2007)
Protein Engineering of Haloalkane Dehalogenases: Towards the Change of Reaction Mechanism (2008)
Development of Enzyme Biosensors for Detection of Toxic Halogenated Compounds (2008)
Semi-Rational Engineering of Haloalkane Dehalogenases DHAA Towards Improved Activity with 1,2-Dichloroethane (2008)
Quantitative Comparison of Binding Sites within the Protein Family of Haloalkane Dehalogenases, (2008)
Characterization of Haloalkane Dehalogenase DmbC from Mycobacterium tubercul.sis H37Rv, (2008)
Inženýrství stereoselektivity enzymů pro aplikace biokatalýzy (2008)
Modulation of Enantioselectivity in Haloalkane Dehalogenase DbjA by Engineering of a Surface Loop (2008)
Thermodynamic Analysis of Enantioselectivity of Haloalkane Dehalogenase DbjA and its Variants DbjA and DbjA+H139A towards Brominated Esters and substituted Bromoalkanes (2008)
Determination of capsidiol in tobacco cells culture by HPLC (2010)
Decontamination of chemical warfare agent sulphur mustard (2008)
Recombinant enzyme haloalkane dehalogenase LinB (2008)
Recombinant enzyme haloalkane dehalogenase DhaA (2008)
Recombinant enzyme haloalkane dehalogenase DbjA (2008)
Recombinant enzyme haloalkane dehalogenase DmbA (2008)
Recombinant enzyme haloalkane dehalogenase DhmA (2008)
Recombinant enzyme haloalkane dehalogenase DmbB (2008)
Recombinant enzyme haloalkane dehalogenase DmbC (2009)
Recombinant enzyme haloalkane dehalogenase DrbA (2009)
Recombinant enzyme haloalkane dehalogenase DbeA (2009)
Fluorescence spectrophotometer TUH-01 (2008)
Pathways and Mechanisms for Product Release in the Engineered Haloalkane Dehalogenases Explored using Classical and Random Acceleration Molecular Dynamics Simulations. (2009)
Chiral Aliphatic Hydroxy Compounds in Nature: a Review of Biological Functions and Practical Applications. (2009)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2007)
Early Warning Biosensors for Detection of Chemical Warfare Agents. (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
Development of an enzymatic fiber-optic biosensor for detection of halogenated hydrocarbons. (2010)
Biochemical and structural characterization of novel haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94 possesing two halide binding sites (2010)
Effect of organic solvents on structure and function of haloalkane dehalogenases (2010)
Engineering of Enzymes by Modification of Access Tunnels (2010)
Engineering of Biocatalysts by Modification of Access Tunnels (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
CONSTRUCTION AND CHARACTERIZATION OF FIBER-OPTIC BIOSENSOR BASED ON HALOALKANE DEHALOGENASE (2010)
Optical biosensor based on haloalkane dehalogenase for detection of halogenated hydrocarbons in the environment. (2010)
Struktura a funkce haloalkándehalogenas v organických rozpouštědlech (2010)
Haloalkane dehalogenase from Agrobacterium tumefaciens C58 with new halide-stabilising residues and unique kinetics (2010)
Investigation of Ligand Passage in Proteins Investigation of Ligand Passage in Proteins (2010)
Kinetics and enantioselectivity of haloalkane dehalogenase from Agrobacterium tumefaciens c58 (2010)
Biology and Bioinformatics (2011)
Construction of pollutant-degrading bacteria by protein and metabolic engineering (2011)
In vitro protein and metabolic engineering of a biodegradation pathway (2011)
Molecular bases of enantioselectivity of haloalkane dehalogenase DbjA. (2011)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of pH and Temperature. (2011)
Biochemical Characteristics of the Novel Haloalkane Dehalogenase DatA Isolated from the Plant Pathogen Agrobacterium tumefaciens C58. (2011)
Biodegradation of 1,2,3-Trichloropropane (2011)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
Molecular mechanisms of the effects of organic solvents on activity of haloalkane dehalogenases (2011)
Molekulární podstata působení organických rozpouštědel na strukturu a funkci haloalkandehalogenáz (2011)
Decontamination kit Yperzyme (2011)
Recombinant enzyme haloalkane dehalogenase DmxA (2011)
Recombinant enzyme haloalkane dehalogenase Spur (2011)
Recombinant enzyme haloalkane dehalogenase DpcA (2011)
Sphingobium czechense LL01 sp. nov (2011)
Novosphingobium barchaimii LL02 sp. nov (2011)
Sphingobium baderi LL03 sp. nov (2011)
Fluorimetr pro biosensorové měření (2011)
HaloPen (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
ZPŮSOB DETOXIKACE SULFIDICKÉHO YPERITU ÚČINKEM HALOGENALKANDEHALOGENÁZ (2007)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2009)
A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB (2012)
Conjugation of 5(6)-carboxyfluorescein and 5(6)-carboxynaphthfluorescein with bovine serum albumin and their immobilization for optical pH sensing (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA57 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA61 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA63 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA80 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA82 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA85 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA88 (2012)
Haloalkane dehalogenases: Biotechnological applications (2013)
Expansion of Access Tunnels and Active-Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents. (2013)
The Effect of a Unique Halide-Stabilising Residue on the Catalytic Properties of Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 (2013)
Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel (2013)
Sphingobium czechense sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Novosphingobium barchaimii sp nov., isolated from hexachlorocyclohexane-contaminated soil (2013)
Sphingobium baderi sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Immobilization of Haloalkane Dehalogenase LinB from Sphingobium japonicum UT26 for Biotechnological Applications (2013)
Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents (2013)
Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations. (2013)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents (2013)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2013)
Miniaturizovaný příruční fluorimetr (2013)
E. coli degWT upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli degWT-opt- upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31 upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
Rekombinantní enzym haloalkan dehalogenáza DatA. (2013)
Rekombinantní enzym haloalkan dehalogenáza DspA. (2013)
Stepwise Enhancement of Catalytic Performance of Haloalkane Dehalogenase LinB towards Beta-Hexachlorocyclohexane. (2014)
Maximizing the Efficiency of Multi-enzyme Process by Stoichiometry Optimization. (2014)
Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane. (2014)
Structural and Functional Analysis of a Novel Haloalkane Dehalogenase with Two Halide-Binding Sites. (2014)
Microscopic Monitoring Provides Information on Structure and Properties During Biocatalyst Immobilisation. (2014)
Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design. (2014)
Computer-Assisted Engineering of Synthetic Pathway for Biodegradation of Toxic Persistent Pollutant. (2014)
Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets (2015)
Rekombinantní enzym haloalkane dehalogenase HTS001 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS003 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS004 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS005 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS010 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS006 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS013 (2014)
Geneticky modifikovaná bakterie degradující toxické environmentalní polutanty Ps. putida CF4 deg31 (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 deg 31 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na chromosomu (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na plasmidu. (2014)
Exacerbation of Substrate Toxicity by IPTG in Escherichia coli BL21(DE3) Carrying a Synthetic Metabolic Pathway (2015)
Bioavailability and mobility of organic contaminants in soil: new three-step ecotoxicological evaluation (2016)
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants (2015)
Novel LinA Type 3 delta-Hexachlorocyclohexane Dehydrochlorinase (2015)
Mechanism-Based Discovery of Novel Substrates of Haloalkane Dehalogenases using in Silico Screening (2015)
Detekční proužky (2015)
DsvA from Saccharomonospora viridis DSM 43017 (2015)
Enzyme haloalkane dehalogenase DmxA from Marinobacter sp. ELB17 purified to homogeneity (2015)
Recombinant ancestral enzyme ancHLD-Rluc (2015)
Recombinant ancestral enzyme ancLinB-DmbA (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD1 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD2 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD3 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD4 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD5 (2015)
Device for Detection of Halogenated Hydrocarbons (2016)
Firmware k ovládání biosensoru (2015)
Imunosensory pro rychlou detekci patogenních mikroorganismů (2016)
Discovery of Novel Haloalkane Dehalogenase Inhibitors (2016)
Rapid Immunosensing of Salmonella Typhimurium Using Electrochemical Impedance Spectroscopy: the Effect of Sample Treatment (2016)
Gelatin-templated Nanostructured Gold for Electrochemical Detection of Glucose in Serum (2016)
The Dynamics of Xylem Sap pH under Drought: a Universal Response in Herbs? (2016)
Engineering a de Novo Transport Tunnel (2016)
Enzyme Based Test Stripes for the Visual or Photographic Detection and Quantitation of Gaseous Sulfur Mustard (2016)
Fluorescence-Based Biosensor for Monitoring of Environmental Pollutants: From Concept to Field Application. (2016)
Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB (2016)
Mikrofluidní čip pro teplotní gradient (2016)
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging (2017)
Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges (2017)
Immunosensors for detection of pathogenic bacteria (2017)
Recombinant enzyme haloalkane dehalogenase LinB116 carrying thermostabilizing mutations by FRESCO with removed disulphide bridge. (2017)
Biosensorická špička s DgpA pro detekci v nízké teplotě 10 oC (2017)
Biosensorická špička s DhmeA pro detekci v alkalických podmínkách pH 10 (2017)
Biosensorická špička s LinA a LinB pro detekci beta-HCH (2017)
Recombinant enzyme gamma-hexachlorocyclohexane dehydrochlorinase LinA01 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA101 carrying thermostabilizing mutations by evolution-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA112 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA115 carrying thermostabilizing mutations by combine approach (2017)
Recombinant enzyme halohydrin dehalogenase HheC01 carrying thermostabilizing mutations (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT01 carrying thermostabilizing mutations. (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT02 carrying thermostabilizing mutations. (2017)
Recombinant enzyme haloalkane dehalogenase eHLD2 (2017)
Recombinant enzyme haloalkane dehalogenase eHLD3 (2017)
Recombinant enzyme halohydrin dehalogenase HheC-DJ carrying thermostabilizing mutations. (2017)
A Haloalkane Dehalogenase From a Marine Microbial Consortium Possessing Exceptionally Broad Substrate Specificity (2018)
Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating (2017)
Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets (2017)
Metagenome-derived Haloalkane Dehalogenases with Novel Catalytic Properties (2017)
Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (2017)
Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open–Solvated versus Occluded–Desolvated Active Sites (2017)
FireProt: Web Server for Automated Design of Thermostable Proteins (2017)
Kinetics of Binding of Fluorescent Ligands to Enzymes with Engineered Access Tunnels (2017)
Structure-function Relationships and Engineering of Haloalkane Dehalogenases. (2017)
Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling (2017)
Enzyme Tunnels and Gates As Relevant Targets in Drug Design (2017)
Protection of Arabidopsis Blunt-Ended Telomeres Is Mediated by a Physical Association with the Ku Heterodimer (2017)
High-throughput screening of haloalkane dehalogenase libraries based on a pH- sensitive assay using droplet-based microfluidics (2017)
FireProt 1.0 (2017)
CalFitter 1.0 (2017)
Impact of the access tunnel engineering on catalysis is strictly ligand-specific (2018)
Computer-assisted engineering of hyperstable fibroblast growth factor 2 (2018)
Molecular Gating of an Engineered Enzyme Captured in Real Time (2018)
Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips (2018)
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization (2018)
Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site (2018)
CalFitter: a web server for analysis of protein thermal denaturation data (2018)
Sensitive operation of enzyme-based biodevices by advanced signal processing (2018)
Haloalkane Dehalogenases From Marine Organisms (2018)
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization (2018)
Stable fibroblast growth factors in burn medicine research (2019)
Gastrointestinální stromální tumory rekta - hodnocení dat národního registru s ohledem na využití v klinické praxi (2019)
Structural Biology and Protein Engineering of Thrombolytics (2019)
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts (2019)
Fluorescent pH Indicators for Neutral to Near-Alkaline Conditions Based on 9-Iminopyronin Derivatives (2019)
Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics (2019)
Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics (2019)
Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase (2019)
Development of Fluorescent Assay for Monitoring of Dehalogenase Activity (2019)
Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5 (2019)
Transhalogenation Catalysed by Haloalkane Dehalogenases Engineered to Stop Natural Pathway at Intermediate (2019)
Engineering enzyme access tunnels (2019)
Crystallization and Crystallographic Analysis of a Bradyrhizobium Elkanii USDA94 Haloalkane Dehalogenase Variant with an Eliminated Halide-Binding Site (2019)
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity (2019)
Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17 (2019)
An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation (2020)
Machine Learning in Enzyme Engineering (2020)
OPTOFLUIDIC TECHNIQUES FOR DIRECTED EVOLUTION OF ENZYMES (2018)
Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips (2018)
Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor (2019)
Engineering of enzyme gating driven by molecular dynamics, transient kinetics, and single molecule spectroscopy (2018)
Analyzer for Fluorescent Biosensing Application (2011)
Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst (2020)
EnzymeMiner: automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities (2020)
A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability (2020)
Predicting protein stability and solubility changes upon mutations: data perspective (2020)
Exploration of enzyme diversity: High-throughput techniques for protein production and microscale biochemical characterization (2020)
Epidemiology typing and molecular analysis of vancomycin-resistant Enterococcus foeclum in haemato-oncological patients. (2020)
Surface-enhanced Raman Spectroscopy in Microfluidic Chips for Directed Evolution of Enzymes and Environmental Monitoring (2019)
The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step (2020)
Fluorescent substrates for haloalkane dehalogenases: Novel probes for mechanistic studies and protein labeling (2020)
Primal-dual block-proximal splitting for a class of non-convex problems (2020)
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics (2020)
Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family (2020)
Development and Testing of Thrombolytics in Stroke (2021)
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (2019)
Substrate inhibition by the blockage of product release and its control by tunnel engineering (2021)
SoluProt: prediction of soluble protein expression in Escherichia coli (2021)
Exploring mechanism of enzyme catalysis by on-chip transient kinetics coupled with global data analysis and molecular modeling (2021)
Engineering the protein dynamics of an ancestral luciferase (2021)
Úskalí laboratorních metod v ovariálním skríninku - doba "-omická"? (2020)
Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers (2021)
Vliv IFITM1 na „surfaceom“ buněk cervikálního karcinomu (2021)
Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi (2021)
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin (2022)
Tools for computational design and high-throughput screening of therapeutic enzymes (2022)
Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase (2022)
Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase (2021)
Computational enzyme design for metabolic engineering (2021)
IFITM PROTEINS REGULATE IMMUNE-RELATED CELL SURFACE MOLECULES IN CERVICAL CARCINOMA (2022)
IFITM PROTEINS REGULATE SENSITIVITY OF CERVICAL CANCER CELLS TO CISPLATIN (2022)
CalFitter 2.0: Leveraging the power of singular value decomposition to analyse protein thermostability (2022)
Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling (2022)
IMPACT OF ADMINISTRATION METHOD OF THROMBOLYTICS ON THEIR THROMBOLYTIC EFFECTS (2022)
MAPityser 2.1 - Analyzátor dat pro mikrofluidní platformu MAPit (2022)
MicroPEX Data Analyser 1.0* (2022)
Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase (2022)
Advanced database mining of efficient haloalkane dehalogenases by sequence and structure bioinformatics and microfluidics (2022)
Droplet-Based Microfluidic Temperature-Jump Platform for the Rapid Assessment of Biomolecular Kinetics (2022)
熱安定性ＦＧＦ２ポリペプチド及びその使用 (2022)
Catalytic mechanism for Renilla-type luciferases (2023)
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate (2023)
In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning (2023)
Identification, characterization, and engineering of glycosylation in thrombolytics (2023)
Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples (2024)
Poměr plazminogen/plazmin jako ukazatel bezpečnosti trombolytické léčby (2023)
Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning (2023)
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase (2023)
The SAP domain of Ku facilitates its efficient loading onto DNA ends (2023)
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase (2023)
Computer-assisted stabilization of fibroblast growth factor FGF-18 (2023)
Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone (2024)
CRISPR CAS9 ENGINEERED TETRASPANIN DEFICIENT CELL LINES FOR THE ANALYSIS OF EXTRACELLULAR VESICLES (2023)
Nano-enabled pesticides: a comprehensive toxicity assessment of tebuconazole nanoformulations with nematodes at single species and community level (2024)
N-glycan profiling of tissue samples to aid breast cancer subtyping (2024)
Investigation of long non-coding RNAs in extracellular vesicles from low-volume blood serum specimens of colorectal cancer patients (2024)
Changes of serum protein N-glycosylation in cancer (2022)
Determination of PPAR gamma agonistic activity of mimulone and diplacone in nanoparticle formulations (2024)
Visual Support for the Loop Grafting Workflow on Proteins (2024)
A computational workflow for analysis of missense mutations in precision oncology (2024)
CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules (2024)
AggreProt: a web server for predicting and engineering aggregation prone regions in proteins (2024)
Effects of three tebuconazole nanopesticides on the survival of <i>Daphnia magna</i> (2024)
Release and stability of two tebuconazole nanoformulations in different aquatic media (2024)
Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1 (2024)
Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family (2024)
Lipidomic analysis of tetraspanin-deficient extracellular vesicles (2024)
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension (2024)
Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA (2024)
Lipidomic profiling of extracellular vesicles from tetraspanin-deficient cell lines (2024)
Proteomic analysis of tetraspanin-deficient extracellular vesicles (2024)

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