Publication Records

Selected publication/outcome records

A mechanistic approach to deriving Quantitative Structure-Activity Relationship models for microbial degradation of organic compounds (1996)
Molecular orbital calculations to describe microbial reductive dechlorination of polychlorinated dioxins. (1998)
A molecular modelling study of the catalytic mechanism of haloalkane dehalogenase: 1. Quantum chemical study of the first reaction step (1997)
Biotransformation of chloro- and bromoalkenes by crude extracts of Rhodococcus erythropolis Y2 (1997)
Some biochemical properties and the classification of a range of bacterial haloalkane dehalogenases (1997)
A mechanistic approach to deriving Quantitative Structure-Biodegradability Relationships. A case study: dehalogenation of haloaliphatic compounds. (1996)
Computational site-directed mutagenesis of haloalkane dehalogenase in position 172 (1998)
Mechanism-based Quantitative Structure-Biodegradability Relationships for hydrolytic dehalogenation of chloro- and bromoalkenes (1998)
Computer modelling of microbial hydrolytic dehalogenation (1998)
Quantitative Structure-Function and Structure-Stability Relationships of purposely modified proteins (1998)
Repositioning the catalytic triad acid of haloalkane dehalogenase (1997)
Purification and characterization of haloalkane dehalogenase of a new substrate class from g-hexachlorocyclohexane-degrading bacterium (1997)
Quantitative Structure-Function Relationships of the single-point mutants of haloalkane dehalogenase: a multivariate approach (1997)
Comparison of the QSAR models for toxicity and biodegradability of anilines and phenols (1997)
Identification of the catalytic triad in the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (1999)
Structure-biodegradability relationships for chlorinated dibenzo-p-dioxins and dibenzofurans (1998)
Molecular modelling to understand the mechanisms of microbial degradation - application to hydrolytic dehalogenation with haloalkane dehalogenases (1997)
Biodegradability prediction (1996)
A molecular modelling study of the catalytic mechanism of haloalkane dehalogenase: 2. Quantum chemical study of complete reaction mechanism. (1998)
Polychlorinated dibenzo-p-dioxins in anaerobic soils and sediments (1996)
Sporulation as an effective strategy for the survival of bacteria in a biofilter with discontinuous operation (1999)
Tetrachloroethene-dehalogenating bacteria (1999)
Construction and characterization of histidine-tagged haloalkane dehalogenase (LinB) of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26 (1999)
Analysis of the reaction mechanism and substrate specificity of haloalkane dehalogenases by sequential and structural comparisons (1999)
Dehalogenation of haloalkanes by Mycobacterium tuberculosis H37Rv and other mycobacteria (2000)
Molecular characterization of the Thermomonospora curvata aglA gene encoding a thermotholerant alpha-1,4-glucosidase (2000)
Determination of haloalkane dehalogenase enzymatic activity by capillary zone electrophoresis (2000)
Engineering proteins for the degradation of recalcitrant compounds (2000)
Stability of Complexes of Aromatic Amides with Bromide Anion: Quantitative Structure-Property Relationships (2000)
Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (2000)
TRITON: in silico construction of protein mutants and prediction of their activities (2000)
Effect of the carbon source on assessment of degrading bacteria with the spread-plating technique during in situ bioremediation (2000)
TRITON: graphic software for rational engineering of enzymes (2001)
Molecular dissection of interactions between Rad51 and members of the recombination-repair group (2001)
Biochemical characterization of broad-specificity enzymes using multivariate experimental design and a colorimetric microplate assay: characterization of the haloalkane dehalogenase mutants (2001)
Reaction mechanism and stereochemistry of gamma-hexachlorocyclohexane dehydrochlorinase LinA (2001)
Comparative binding energy (COMBINE) analysis of the substrate specificity of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10 (2001)
Insights into the Functional Architecture of the Catalytic Center of a Maize Beta-Glucosidase Zm-p60.1 (2001)
Four novel germline BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer (2001)
Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker (2001)
Structure-specificity relationships for haloalkane dehalogenases (2001)
Identification of protein fold and catalytic residues of g-hexachlorocyclohexane dehydrochlorinase LinA (2001)
Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product and water mediated inhibition (2002)
Functionally relevant motions of haloalkane dehalogenases occur in the specificity-modulating cap domains (2002)
Biodegradation of 1,2,3-trichloropropane through directed evolution and heterologous expression of a haloalkane dehalogenase gene (2002)
Impact of Orthogonal Signal Correction (OSC) on the predictive ability of CoMFA models for the ciliate toxicity of nitrobenzenes (2002)
Role of SdiA in Salmonella enterica serovar typhimurium physiology and virulence (2002)
Cloning, expression and preliminary characterization of novel haloalkane dehalogenase DhmA from Mycobacterium avium N85 (2002)
Identification of Salmonella enterica serovar Typhimurium genes associated with growth suppression in stationary-phase nutrient broth cultures and in the chicken intestine (2002)
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis (2002)
Re-construction of mycobacterial dehalogenase Rv2579 by cumulative mutagenesis of haloalkane dehalogenase LinB (2003)
Cloning and characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a PCB and naphthalene degrading Bacillus sp. JF8 (2003)
Retron reverse transcriptase rrtT is ubiquitous in strains of Salmonella enterica serovar Typhimurium (2003)
Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates (2003)
Comparative binding energy analysis of haloalkane dehalogenase substrates: modelling of enzyme-substrate complexes by molecular docking and quantum mechanical calculations (2003)
Catalytic mechanism of the haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 (2003)
Rational re-design of haloalkane dehalogenases guided by comparative binding energy analysis (2003)
Validation of Putative Enzymes from Genomic Projects: Confirmation of Dehalogenation ARv2ctivity for Mycobacterial Protein 579 (2003)
Modification of Activity and Specificity of Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26 by Engineering of its Entrance Tunnel (2003)
PKD2 Mutations in Czech Population with Autosomal Dominant Polycystic Kidney Disease (2004)
Three-Block Bi-Focal PLS (3BIF-PLS) and its Application in QSAR. (2004)
Binding of Fatty Acids to b-Cryptogein: Quantitative Structure-Activity Relationships and Design of Selective Protein Mutants. (2004)
Crystal Structure of Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A Resolution: Dynamics of Catalytic Residues (2004)
Bioinformatics II (2004)
Alfred Bader - Chemist and Art Collector (2004)
Quantitative Analysis of Substrate Specificity of Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26 (2005)
Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26. (2005)
Construction of Cryptogein Mutants, a Proteinaceous Elicitor from Phytophthora, with Altered Abilities To Induce a Defense Reaction in Tobacco Cells (2005)
Two Rhizobial Strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, Encode Haloalkane Dehalogenases with Novel Structures and Substrate Specificities (2005)
TRITON: graphic software for modelling protein mutants and calculation reaction pathways (2005)
Mycobacterial Haloalkane Dehalogenases: Cloning, Biochemical Properties and distribution. (2005)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2005)
Způsob detoxikace sulfidického yperitu psobením halogenalkandehalogenázami (2005)
Vývoj enzymového biosenzoru pro detekci chlorovaných pesticidů (2005)
Navržení Biosenzoru pro detekci chlorovaných pesticidů (2006)
Elektrochemické stanovení chloridů na uhlíkových elektrodách (2006)
Enzymový Biosenzor pro detekci chlorovaných pesticidů (2006)
Analýza chlorovaných uhlovodíků s využitím stříbrné a uhlíkové pastové elektrody (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides (2006)
Vyvoj enzymoveho biosenzoru pro detekci chlorovanych pesticidu (2006)
High-throughput characterization of enzymes from genomic and proteomic projects-multivariate statistical approach (2006)
Protein engineering of haloalkane dehalogenase LinB: reconstruction of active site and modification of entrance tunnel (2006)
Study of substrate inhibition by electrophoretically mediated microanalysis in partially filled capillary. (2007)
Expression of Glycosylated Haloalkane Dehalogenase LinB in Pichia pastoris. (2006)
Mechanism of Enhanced Conversion of 1,2,3-Trichloropropane by Mutant Haloalkane Dehalogenase Revealed by Molecular Modeling. (2006)
Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. (2007)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2006)
Enzymes Fight Chemicals Weapons. (2006)
Phylogenetic Analysis of Haloalkane Dehalogenases (2007)
CAVER: A New Tool to Explore Routes from Protein Clefts, Pockets and Cavities (2006)
Identification of Tunnels in Proteins, Nucleic Acids, Inorganic Materials and Molecular Ensembles. (2006)
Electrochemical determination of chlorides on surfaces of carbon electrodes. (2006)
Development of biosensor for determination of chlorinated pesticides. (2006)
Engineering of enantioselective enzyme by cumulative mutagenesis. (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides. (2006)
Solvent Isotope Effects on Haloalkane Dehalogenase LinB. (2006)
Mycobacteria as a Source of Haloalkane Dehalogenases: Identification of the Catalytic Pentad within the Structure of DhmA from Mycobacterium avium N85. (2006)
Physical Variables as a Control of Enzyme Stereoselectivity (2006)
Modelling of Product Release and Identification of Export Routes in Haloalkane Dehalogenase DhaA (2006)
Engineering of Enantioselective Haloalkane Dehalogenase by Cumulative Mutagenesis (2006)
Discovery of Stereoselective Haloalkane Dehalogenases: New Tool for Asymmetric Syntheses. (2006)
Expression of Haloalkane Dehalogenase LinB in Pichia pastoris (2006)
Proteinové inženýrství enzymů (2006)
Development of Enzymatic Biosensor for Determination of Chlorinated Pesticides (2006)
Řízení stereoselektivity enzymu fyzikálně-chemickými parametry (2006)
Natural and Engineered Enantioselective Haloalkane Dehalogenases (2006)
Structure-Based Engineering of Haloalkane Dehalogenase (2006)
Engineering of Haloalkane Dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 Towards Higher Enantioselectivity (2006)
The stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of Temperature and pH (2006)
Computer-assisted Directed Evolution of Haloalkane Dehalogenase DhaA Towards Degradation of 1,2,3-Trichloropropane (2006)
Keyhole-Lock-Key Model of Enzyme-Substrate Binding (2006)
The Past, the Present and the Future of Czech Biotechnologies (2006)
Application of Functional Protein Microarrays for Detection of p53 Mutant Activity (2006)
Role of p53 Gene Mutation Type in B-CLL Prognosis (2006)
Reaktivace proteinu p53 pomocí Amifostinu - experimentální studie v kvasinkovém expresním systému (2006)
Bioinformatics III (2006)
Use of Mass Spectrometer for Solid Sample Analysis (2007)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2007)
Second Step of Hydrolytic Dehalogenation in Haloalkane Dehalogenase Investigated by QM/MM Methods (2008)
Identification of Tunnels in Proteins, Nucleic Acids, Inorganic Materials and Molecular Ensembles (2007)
Stepwise Dissection and Visualization of the Catalytic Mechanism of Haloalkane Dehalogenase LinB using Molecular Dynamics Simulations and Computer Graphics (2007)
The ecology of Mycobacteria: Impact on Animal´s and Human Health (2009)
Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast (2008)
Characterization of Haloalkane Dehalogenases DrbA and DmbC: Representatives of Novel Subfamily. (2009)
Degradation of Beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Hexachlorocyclohexane-Utilizing Bacterium Sphingobium sp. MI1205 (2007)
High Occurrence of BRCA1 Intragenic Rearrangements in Hereditary Breast and Ovarian Cancer Syndrome in the Czech Republic (2007)
Exploring the Binding Sites of the Haloalkane Dehalogenase DhlA from Xanthobacter autotrophicus GJ10. (2007)
Crystallization and Preliminary Crystallographic Analysis of a Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110. (2007)
Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-ray Crystallography and Microcalorimetry (2007)
Meeting Report: Protein Design and Evolution for Biocatalysis (2007)
Design and Evolution of Haloalkane Dehalogenase with Enhanced Conversion of 1,2,3-Trichloropropane by Modification of Access Tunnels (2009)
Comparison of Broad-Specificity Haloalkane Dehalogenases DbjA and DmbA Using Multivariate Statistical Approach. (2008)
Enzymatic reaction coupled with flow-injection analysis with charged aerosol, coulometric, or amperometric detection for estimation of contamination of the environment by pesticides (2008)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The effect of temperature and pH (2007)
Haloalkane Dehalogenases Possess Two Different Structural Bases for Their Enantioselectivity (2007)
Comparative Binding Energy (COMBINE) Analysis of the Substrate Specificity of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110. (2007)
Biomolecular Diversity (2007)
Keyhole-Lock-Key Model of Enzymatic Catalysis: Engineering of Tunnels in Proteins with Buried Active Sites (2007)
New Trends in Protein Engineering and White Biotechnologie (2007)
Změna enantioselektivity a substrátové specifity haloalkan dehalogenázy proteinovým inženýrstvím (2007)
Comparative Binding Energy Analysis of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110 (2007)
Development of Enzymatic Biosensors for Detection of Halogenated Environmental Pollutants (2007)
Stereoselektivita a konformační stabilita halogenalkan dehalogenázy DbjA z Bradyrhizobium japonicum USDA110, (2007)
Využití enzymů ve farmaceutických výrobách (2007)
Enzymatic Detoxification of Sulfur Mustard by Haloalkane Dehalogenases (2007)
Crystallization study of three mutant haloalkane dehalogenases derived from dehalogenase DhaA of Rhodococcus rhodochrous NCIMB 13064 (2007)
Evolution of Haloalkane Dehalogenase Protein Family (2007)
LinB Enzyme for Detection of Chlorinated Pesticides- Suggestion Design of a New Biosensor (2007)
Functional analysis of aglycone-binding site of the maize beta-glucosidase Zm-p60.1 (2007)
Funkční analýza aglykon-vazebného místa kukuřičné beta-glukozidázy Zm-p60.1 (2007)
ward of the Rector of the Masaryk University (2007)
Crystals of DhaA Mutants from Rhodococcus rhodochrous NCIMB 13064 Diffracted to Ultrahigh Resolution: Crystallization and Preliminary Diffraction Analysis. (2008)
Protein Engineering of Haloalkane Dehalogenases: Towards the Change of Reaction Mechanism (2008)
Development of Enzyme Biosensors for Detection of Toxic Halogenated Compounds (2008)
Quantitative Comparison of Binding Sites within the Protein Family of Haloalkane Dehalogenases, (2008)
Characterization of Haloalkane Dehalogenase DmbC from Mycobacterium tubercul.sis H37Rv, (2008)
Crystallization and preliminary diffraction analysis of Rhodococcus rhodocrous NCIMB 13064 DhaA mutants (2008)
Inženýrství stereoselektivity enzymů pro aplikace biokatalýzy (2008)
Nanosecond Time-Dependent Stokes Shift at the Tunnel Mouth of Haloalkane Dehalogenases (2009)
Modulation of Enantioselectivity in Haloalkane Dehalogenase DbjA by Engineering of a Surface Loop (2008)
Thermodynamic Analysis of Enantioselectivity of Haloalkane Dehalogenase DbjA and its Variants DbjA and DbjA+H139A towards Brominated Esters and substituted Bromoalkanes (2008)
HotSpot Wizard: Web Server for Identification of Hot Spots for Mutagenesis Experiments (2008)
Analysis of Substrate Specificities of Wild-type Haloalkane Dehalogenases and their Mutants by Multivariate Statistics (2008)
Pathways and Mechanisms for Product Exit and Water Exchange in Engineered Haloalkane Dehalogenase DhaA Exploredusing Classical and Random Acceleration Molecular Dynamics Simulations (2008)
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (2008)
Functional analysis of the aglycone - binding site of the maize beta-glucosidase Zm-p60.1 (2008)
Genetický polymorfismus CYP2D6 u pacientů léčených Paroxetinem a modelování mutantních forem CYP2D6 (2008)
Klinické výsledky testování aktivity CYP2D6 a jejich srovnání s počítačovým modelováním (2009)
CAVER 2.0 (2008)
HOTSPOT WIZARD 1.0 (2008)
Decontamination of chemical warfare agent sulphur mustard (2008)
Recombinant enzyme haloalkane dehalogenase LinB (2008)
Recombinant enzyme haloalkane dehalogenase DhaA (2008)
Recombinant enzyme haloalkane dehalogenase DbjA (2008)
Recombinant enzyme haloalkane dehalogenase DmbA (2008)
Recombinant enzyme haloalkane dehalogenase DhmA (2008)
Recombinant enzyme haloalkane dehalogenase DmbB (2008)
Recombinant enzyme haloalkane dehalogenase DmbC (2009)
Recombinant enzyme haloalkane dehalogenase DrbA (2009)
Recombinant enzyme haloalkane dehalogenase DbeA (2009)
Fluorescence spectrophotometer TUH-01 (2008)
Computational Tools for Designing and Engineering Biocatalysts. (2009)
Crystallization and Preliminary X-ray Analysis of a Novel Haloalkane Dehalogenase DbeA from Bradyrhizobium elkani USDA94. (2009)
Editorial: Protein Design and Engineering for Biocatalysis. (2009)
HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. (2009)
Redesigning Dehalogenase Access Tunnels as a Strategy for Degrading an Anthropogenic Substrate. (2009)
Pathways and Mechanisms for Product Release in the Engineered Haloalkane Dehalogenases Explored using Classical and Random Acceleration Molecular Dynamics Simulations. (2009)
Study of water molecule dynamics at the tunnel openings of haloalkane dehalogenase (2009)
Engineering of tunnels in proteins with buried active sites (2009)
Quantitative Analyses of Substrate Specifity of Haloalkane Dehalogenase (2009)
Computer-Assisted Engineering of Biomolecules (2009)
Studium dynamiky molekul vody v ústí tunelu haloalkándehalogenáz (2009)
.: Keyhole-Lock-Key Model: Engineering of Tunnels in Proteins with Buried Active Sites (2009)
NMR Structure of the N-Terminal Domain of Capsid Protein from the Mason-Pfizer Monkey Virus (2009)
Chiral Aliphatic Hydroxy Compounds in Nature: a Review of Biological Functions and Practical Applications. (2009)
Rad52 SUMOylation affects the efficiency of the DNA repair (2010)
HotSpot Wizard: a web server for protein engineering (2009)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2007)
Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation (2010)
Application of functional protein microarrays for detection of p53 mutation activity. (2006)
Analýza p53 mutací in vitro a in vivo (2010)
Early Warning Biosensors for Detection of Chemical Warfare Agents. (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
Atomic resolution studies of haloalkane dehalogenases DhaA04, DhaA14 and DhaA15 with engineered access tunnels. (2010)
Development of an enzymatic fiber-optic biosensor for detection of halogenated hydrocarbons. (2010)
Systems biology at work (2010)
Biochemical and structural characterization of novel haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94 possesing two halide binding sites (2010)
Effect of organic solvents on structure and function of haloalkane dehalogenases (2010)
HOTSPOT WIZARD: NÁSTROJ PRO INŽENÝRSTVÍ ENZYMŮ (2010)
Characterization of novel haloalkane dehalogenase DhcA from extremophilic microorganism Hahella chejuensis KCTC 2396 (2010)
Engineering of Enzymes by Modification of Access Tunnels (2010)
Engineering of Biocatalysts by Modification of Access Tunnels (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
Structure and activity of haloalkane dehalogenases in organic co-solvents (2010)
SENSING HYDRATION AND MOBILITY AT THE VICINITY OF THE ACTIVE SITE OF ENZYMES BY MEANS OF FLUORESCENCE SPECTROSCOPY (2010)
Role of tunnels in enzymes (2009)
Protein Engineering of Biocatalysts (2010)
Increasing activity of bacterial biocatalyst with toxic anthropogenic substrate using methods of protein engineering. (2010)
CONSTRUCTION AND CHARACTERIZATION OF FIBER-OPTIC BIOSENSOR BASED ON HALOALKANE DEHALOGENASE (2010)
Optical biosensor based on haloalkane dehalogenase for detection of halogenated hydrocarbons in the environment. (2010)
Struktura a funkce haloalkándehalogenas v organických rozpouštědlech (2010)
Haloalkane dehalogenase from Agrobacterium tumefaciens C58 with new halide-stabilising residues and unique kinetics (2010)
Investigation of Ligand Passage in Proteins Investigation of Ligand Passage in Proteins (2010)
Structural analysis of DhaA12 mutant of the haloalkane dehalogenase from Rhodococcus rhodochrous NCIMB 13064, (2010)
Crystallization and preliminary X-ray analysis of DhaA wild type and DhaA13 proteins from Rhodococcus rhodochrous (2010)
Kinetics and enantioselectivity of haloalkane dehalogenase from Agrobacterium tumefaciens c58 (2010)
How do organic solvents affecthaloalkane dehalogenases of haloalkane dehalogenases? (2010)
CAVER 2.1 (2010)
Elicitine-membrane interaction is driven by a positive charge on the protein surface: Role of Lys13 residue in lipids loading and resistance induction (2011)
Development of a Crystallization Protocol for the DbeA1 Variant of Novel Haloalkane Dehalogenase from Bradyrhizobium elkani USDA94 (2011)
Substrate Specificity of Haloalkane Dehalogenases (2011)
Crystallization and Preliminary X-ray Diffraction Analysis of the Wild-Type Haloalkane Dehalogenase DhaA and its Variant DhaA13 Complexed with Different Ligands (2011)
Keyhole-Lock-Key Model of Enzymatic Catalysis (2011)
Biology and Bioinformatics (2011)
Engineering Robust and Efficient Protein Catalysts (2011)
Construction of pollutant-degrading bacteria by protein and metabolic engineering (2011)
In vitro protein and metabolic engineering of a biodegradation pathway (2011)
Molecular bases of enantioselectivity of haloalkane dehalogenase DbjA. (2011)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of pH and Temperature. (2011)
Crystallization and Crystallographic Analysis of the Rhodococcus rhodochrous NCIMB 13064 DhaA Mutant DhaA31 and its Complex with 1,2,3-Trichloropropane (2011)
Biochemical Characteristics of the Novel Haloalkane Dehalogenase DatA Isolated from the Plant Pathogen Agrobacterium tumefaciens C58. (2011)
Biodegradation of 1,2,3-Trichloropropane (2011)
Computer-Assisted Enzyme Engineering by Modification of Tunnels, Channels and Gates. (2011)
Crystallization and structural analysis of DhaA31 from Rhodococcus rhodochrous (2011)
Crystallization and Preliminary Crystallographic Analysis of Rhodococcus rhodochrous Wild-type DhAa Protein and its Variant DhaA13 Complexed with Different Ligands (2011)
HOTSPOT WIZARD: WEB APPLICATION FOR PROTEIN ENGINEERING AND STRUCTURAL ANNOTATION (2011)
CAVER 3.0: A Tool For Efficient Analysis Of Tunnels In Dynamic Protein Structures (2011)
Effects of Organic Co-Solvents on Enzyme Activity: In Silico Analysis (2011)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
A Study of Cytosine Oligonucleotides by Voltammetric and Spectral Methods (2011)
CETOCOEN project: From the Laboratory to the Field and Beyond (2011)
The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo (2011)
The new platinum anticancer agent LA-12 induces Retinol Bionding Protein 4 in vivo (2011)
An induction of Retinol Binding Protein 4 by new platinum-based anticancer agent LA-12 (2011)
Medium and protein engineering for improvement of biocatalysis in non-conventional media (2011)
Molecular mechanisms of the effects of organic solvents on activity of haloalkane dehalogenases (2011)
Molekulární podstata působení organických rozpouštědel na strukturu a funkci haloalkandehalogenáz (2011)
Physiological and proteomic approaches to evaluate the role of sterol binding in elicitin-induced resistance (2012)
Decontamination kit Yperzyme (2011)
Recombinant enzyme haloalkane dehalogenase DmxA (2011)
Recombinant enzyme haloalkane dehalogenase Spur (2011)
Recombinant enzyme haloalkane dehalogenase DpcA (2011)
Sphingobium czechense LL01 sp. nov (2011)
Novosphingobium barchaimii LL02 sp. nov (2011)
Sphingobium baderi LL03 sp. nov (2011)
CAVER 3.0 (2011)
Fluorimetr pro biosensorové měření (2011)
HaloPen (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
ZPŮSOB DETOXIKACE SULFIDICKÉHO YPERITU ÚČINKEM HALOGENALKANDEHALOGENÁZ (2007)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2009)
CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures (2012)
Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica (2012)
A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB (2012)
Biochemical Characterization of a Novel Haloalkane Dehalogenase from a Cold-Adapted Bacterium (2012)
Conjugation of 5(6)-carboxyfluorescein and 5(6)-carboxynaphthfluorescein with bovine serum albumin and their immobilization for optical pH sensing (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA57 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA61 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA63 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA80 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA82 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA85 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA88 (2012)
Are Time-Dependent Fluorescence Shifts at the Tunnel Mouth of Haloalkane Dehalogenase Enzymes Dependent on the Choice of the Chromophore? (2013)
DspA from Strongylocentrotus purpuratus: the First Biochemically Characterized Haloalkane Dehalogenase of Non-Microbial Origin. (2013)
Software tools for identification, visualization and analysis of protein tunnels and channels (2013)
Haloalkane dehalogenases: Biotechnological applications (2013)
Crystallographic Analysis of New Psychrophilic Haloalkane Dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17 (2013)
Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. (2013)
Expansion of Access Tunnels and Active-Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents. (2013)
The Effect of a Unique Halide-Stabilising Residue on the Catalytic Properties of Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 (2013)
Organic Co-solvents Affect Activity, Stability and Enantioselectivity of Haloalkane Dehalogenases (2013)
Differences in crystallization of two LinB variants from Sphingobium japonicum UT26 (2013)
Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel (2013)
Sphingobium czechense sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Novosphingobium barchaimii sp nov., isolated from hexachlorocyclohexane-contaminated soil (2013)
Sphingobium baderi sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface (2013)
Gates of Enzymes. (2013)
Immobilization of Haloalkane Dehalogenase LinB from Sphingobium japonicum UT26 for Biotechnological Applications (2013)
Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family (2013)
The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination (2013)
Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents (2013)
Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations. (2013)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents (2013)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2013)
Miniaturizovaný příruční fluorimetr (2013)
PredictSNP 1.0 (2013)
E. coli degWT upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli degWT-opt- upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31 upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
Rekombinantní enzym haloalkan dehalogenáza DatA. (2013)
Rekombinantní enzym haloalkan dehalogenáza DspA. (2013)
CAVER Analyst 1.0: Graphic tool for interactive visualization and analysis of tunnels and channels in protein structures (2014)
Stepwise Enhancement of Catalytic Performance of Haloalkane Dehalogenase LinB towards Beta-Hexachlorocyclohexane. (2014)
A Pseudomonas putida Strain Genetically Engineered for 1,2,3-Trichloropropane Bioremediation. (2014)
Maximizing the Efficiency of Multi-enzyme Process by Stoichiometry Optimization. (2014)
Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane. (2014)
Structural and Functional Analysis of a Novel Haloalkane Dehalogenase with Two Halide-Binding Sites. (2014)
Fructose 1-Phosphate is the One and Only Physiological Effector of the Cra (FruR) regulator of Pseudomonas putida. (2014)
Microscopic Monitoring Provides Information on Structure and Properties During Biocatalyst Immobilisation. (2014)
Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design. (2014)
Comparison of Catalysis by Haloalkane Dehalogenases in Aqueous Solutions of a Deep Eutectic and Organic Solvents. (2014)
PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations. (2014)
Computer-Assisted Engineering of Synthetic Pathway for Biodegradation of Toxic Persistent Pollutant. (2014)
Computational Tools for Designing and Engineering Enzymes. (2014)
Crystallographic Analysis of 1,2,3–Trichloropropane Biodegradation by Haloalkane Dehalogenase DhaA31 (2014)
Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets (2015)
Retro operation on the Trp-cage miniprotein sequence produces an unstructured molecule capable of folding similar to the original only upon 2,2,2-trifluoroethanol addition (2014)
Rekombinantní enzym haloalkane dehalogenase HTS001 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS003 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS004 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS005 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS010 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS006 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS013 (2014)
Geneticky modifikovaná bakterie degradující toxické environmentalní polutanty Ps. putida CF4 deg31 (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 deg 31 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na chromosomu (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na plasmidu. (2014)
Upravený rekombinantní enzym haloalkan dehalogenasa DbeA 01 (2014)
Upravený rekombinantní enzym haloalkan dehalogenase DbeA03 (2014)
Caver Analyst 1.0 (2014)
Upravený rekombinantní enzym haloalkan dehalogenasa DbeA 02 (2014)
Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence. (2015)
Balancing the Stability-Activity Trade-off by Fine-Tuning Dehalogenase Access Tunnels. (2015)
Instability restricts signaling of multiple fibroblast growth factors (2015)
Výuka bioinformatiky pro studenty biologických oborů na Masarykově univerzitě (2012)
CAVER: Algorithms for Analyzing Dynamics of Tunnels in Macromolecules (2016)
Nanostructured surface modifications for stem cell studie (2014)
Exacerbation of Substrate Toxicity by IPTG in Escherichia coli BL21(DE3) Carrying a Synthetic Metabolic Pathway (2015)
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants (2015)
Mechanism-Based Discovery of Novel Substrates of Haloalkane Dehalogenases using in Silico Screening (2015)
Nanostructured surfaces for studying the cellular interactions (2015)
Nanostrukturovaný povrch pro studium mezibuněčných interakcí kmenových buněk (2015)
Nanostructured surfaces as a promising tool for studying the cellular interactions (2015)
Novel approach for studying of cell interactions via nanostructured surfaces (2015)
Preparation of nanostructured molecular lawn as tool for studying the cellular interactions (2015)
Detekční proužky (2015)
PredictSNP 2.0 (2015)
HotSpot Wizard 2.0 (2015)
CaverWeb 0,2 (2015)
DsvA from Saccharomonospora viridis DSM 43017 (2015)
Enzyme haloalkane dehalogenase DmxA from Marinobacter sp. ELB17 purified to homogeneity (2015)
Recombinant ancestral enzyme ancHLD-Rluc (2015)
Recombinant ancestral enzyme ancLinB-DmbA (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD1 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD2 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD3 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD4 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD5 (2015)
Device for Detection of Halogenated Hydrocarbons (2016)
Thermostable FGF2 Polypeptide, Use Thereof (2020)
Hydrolases in Non-Conventional Media: Implications for Industrial Biocatalysis (2015)
The Position of His-Tag in Recombinant OspC and Application of Various Adjuvants Affects the Intensity and Quality of Specific Antibody Response after Immunization of Experimental Mice (2016)
Discovery of Novel Haloalkane Dehalogenase Inhibitors (2016)
Nanostrukturování povrchů jako slibný nástroj pro studium buněčných interakcí kmenových buněk (2016)
Nanostructured Surfaces for Studying the Cellular Interactions (2016)
Nanostructured molecular lawn-powerful tool for studying cellular interactions (2016)
Suppression of protein inactivation during freezing by minimizing pH changes using ionic cryoprotectants (2016)
Engineering a de Novo Transport Tunnel (2016)
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions (2016)
HotSpot Wizard 2.0: Automated Design of Site-Specific Mutations and Smart Libraries in Protein Engineering (2016)
Enzyme Based Test Stripes for the Visual or Photographic Detection and Quantitation of Gaseous Sulfur Mustard (2016)
Fluorescence-Based Biosensor for Monitoring of Environmental Pollutants: From Concept to Field Application. (2016)
Role of Tunnels and Gates in Enzymatic Catalysis (2016)
Computational Tools for Designing Smart Libraries (2014)
Mikrofluidní čip pro teplotní gradient (2016)
pqsfinder: identification of potential quadruplex forming sequences (2017)
Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells (2017)
Vliv růstových faktorů na biologickou aktivitu nanostrukturovaných vstřebatelných kožních náhrad: in-vitro a in-vivo experimentální studie (2017)
Fibroblastový růstový faktor jako dynamický regulátor morfogeneze mléčné žlázy (2017)
Direct nanopatterning of biomolecules by electron beam lithography for studying of cellular interaction (2017)
Dissecting the roles of fibroblast growth factor (FGF) signalling in mammary branching morphogenesis using hyperstable FGF2 variants (2017)
Watergate: Visual Exploration of Water Trajectories in Protein Dynamics (2017)
Fibroblast growth factor (FGF) as a dynamic regulator of mammary gland branching morphogenesis (2017)
Computational Analysis of Protein Tunnels and Channels (2018)
CaverDock 1.0 (2017)
Fibroblast growth factor (FGF) hypersignalling leads to hyperplasia of mammary epithelium through a stronger erk pathway activation (2017)
Recombinant enzyme haloalkane dehalogenase LinB116 carrying thermostabilizing mutations by FRESCO with removed disulphide bridge. (2017)
Recombinant enzyme gamma-hexachlorocyclohexane dehydrochlorinase LinA01 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA101 carrying thermostabilizing mutations by evolution-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA112 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA115 carrying thermostabilizing mutations by combine approach (2017)
Recombinant enzyme halohydrin dehalogenase HheC01 carrying thermostabilizing mutations (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT01 carrying thermostabilizing mutations. (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT02 carrying thermostabilizing mutations. (2017)
Recombinant enzyme haloalkane dehalogenase eHLD2 (2017)
Recombinant enzyme haloalkane dehalogenase eHLD3 (2017)
HTS 1.0 (2017)
Recombinant enzyme halohydrin dehalogenase HheC-DJ carrying thermostabilizing mutations. (2017)
A Haloalkane Dehalogenase From a Marine Microbial Consortium Possessing Exceptionally Broad Substrate Specificity (2018)
Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating (2017)
Gram-scale Production of Recombinant Microbial Enzymes in Shake Flasks (2018)
Bioremediation 3.0: Engineering Pollutant-Removing Bacteria in the Times of Systemic Biology (2017)
Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets (2017)
Metagenome-derived Haloalkane Dehalogenases with Novel Catalytic Properties (2017)
NewProt – a Protein Engineering Portal (2017)
Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (2017)
Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open–Solvated versus Occluded–Desolvated Active Sites (2017)
FireProt: Web Server for Automated Design of Thermostable Proteins (2017)
Kinetics of Binding of Fluorescent Ligands to Enzymes with Engineered Access Tunnels (2017)
Structure-function Relationships and Engineering of Haloalkane Dehalogenases. (2017)
Pyrazolotriazines as inhibitors of nucleases (2017)
Preparation of nanostructured surfaces to influence hPSC behavior (2018)
FGF2 hypersignalling as a tool to study mammary epithelial branched pattern formation (2018)
Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling (2017)
Enzyme Tunnels and Gates As Relevant Targets in Drug Design (2017)
High-throughput screening of haloalkane dehalogenase libraries based on a pH- sensitive assay using droplet-based microfluidics (2017)
FireProt 1.0 (2017)
CalFitter 1.0 (2017)
NewProt 1.0 (2017)
Computational Enzyme Design of Haloalkane Dehalogenases for Yperite Degradation (2018)
Impact of the access tunnel engineering on catalysis is strictly ligand-specific (2018)
Computer-assisted engineering of hyperstable fibroblast growth factor 2 (2018)
CAVER Analyst 2.0: Analysis and Visualization of Channels and Tunnels in Protein Structures and Molecular Dynamics Trajectories (2018)
Inovativní dermální kolagenová matrix s nanovlákennou vrstvou obohacená o stabilní růstový faktor pro fibroblasty 2 (FGF2): První zkušenosti na in vitro a in vivo modelech (2018)
Preliminary in vitro results of a temporary antimicrobial biopolymer hydrogel optimalization for selected growth factors in partial-thickness skin defects (2018)
Pyrazolotriazines as inhibitors of nucleases (2018)
Vývoj biopolymerní nanostrukturované dermální náhrady: In vivo studie na prasečím modelu (2018)
Vývoj biopolymerní nanostrukturované dermální náhrady: In vivo studie na prasečím modelu (2018)
Vývoj biopolymerní nanostrukturované dermální náhrady: Ex ovo a in vivo studie (2018)
First in vitro preliminary results of newly developed temporary antibacterial biopolymer hydrogels with selected growth factors (2018)
Development of stable FGF2 enriched biopolymer nanostructured dermal substitute: Ex ovo and in vivo study (2018)
Innovative collagen-based nanotechnologically modified dermal substitute containing stable fibroblast growth factor 2 (FGF2): first impression of in-vitro and in-vivo models (2018)
Pyrazolotriazines as inhibitors of nucleases (2018)
Visual Analysis of Ligand Trajectories in Molecular Dynamics (2019)
Molecular Gating of an Engineered Enzyme Captured in Real Time (2018)
Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips (2018)
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization (2018)
Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site (2018)
CalFitter: a web server for analysis of protein thermal denaturation data (2018)
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information (2018)
Sensitive operation of enzyme-based biodevices by advanced signal processing (2018)
Haloalkane Dehalogenases From Marine Organisms (2018)
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization (2018)
Computational Analysis of Protein Tunnels and Channels (2017)
CaverDock: A Novel Method for the Fast Analysis of Ligand Transport (2020)
Bilaminární kožní dermální náhrada: Vliv stabilního FGF2 na kapilární denzitu sledovanou pomocí modelů ex-ovo a in vivo (2019)
Analysis of Long Molecular Dynamics Simulations Using Interactive Focus+Context Visualization (2019)
Stable fibroblast growth factors in burn medicine research (2019)
Gastrointestinální stromální tumory rekta - hodnocení dat národního registru s ohledem na využití v klinické praxi (2019)
Development of an innovative nanostructured dermal matrix in combination with a hyperstable form of growth factor for fibroblasts (FGF2): Ex ovo and in vivo study (2019)
CaverDock: a molecular docking-based tool to analyse ligand transport through protein tunnels and channels (2019)
Caver Web 1.0: identification of tunnels and channels in proteins and analysis of ligand transport (2019)
Structural Biology and Protein Engineering of Thrombolytics (2019)
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts (2019)
Fluorescent pH Indicators for Neutral to Near-Alkaline Conditions Based on 9-Iminopyronin Derivatives (2019)
Collagen-based dermal substitute with stable fibroblast growth factor 2 (FGF2): ex ovo and in vivo impact on neovascularization (2019)
Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics (2019)
New collagen foam with nanotechnological modification as bi-layer dermal substitute: Influence of stable FGF2 on capillary density in different animal models (2019)
Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway (2019)
Testování bilaminární kožní náhrady obohacené stabilním FGF2 na ex ovo a in vivo modelech (2019)
Fast Screening of Inhibitor Binding/Unbinding using Novel Software Tool CaverDock (2019)
Nanopatterning Glass Surface For Localization Of Embryonic Stem Cells (2019)
Deaf learners' processing of English textbook material : An eye-tracking study (2020)
Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics (2019)
Computational Study of Protein-Ligand Unbinding for Enzyme Engineering (2019)
Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase (2019)
Development of Fluorescent Assay for Monitoring of Dehalogenase Activity (2019)
Computational Design of Stable and Soluble Biocatalysts (2019)
Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5 (2019)
Transhalogenation Catalysed by Haloalkane Dehalogenases Engineered to Stop Natural Pathway at Intermediate (2019)
Engineering enzyme access tunnels (2019)
Crystallization and Crystallographic Analysis of a Bradyrhizobium Elkanii USDA94 Haloalkane Dehalogenase Variant with an Eliminated Halide-Binding Site (2019)
NMDA Receptor Opening and Closing-Transitions of a Molecular Machine Revealed by Molecular Dynamics (2019)
Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17 (2019)
An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation (2020)
Machine Learning in Enzyme Engineering (2020)
Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin (2019)
OPTOFLUIDIC TECHNIQUES FOR DIRECTED EVOLUTION OF ENZYMES (2018)
Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips (2018)
Haloalkane dehalogenases as a subject for crystallographic studies (2017)
Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor (2019)
Caver web: identification of tunnels and channels in proteins and analysis of ligand transport (2019)
pqsfinder web: G-quadruplex prediction using optimized pqsfinder algorithm (2020)
Purification and characterization of nitrilase from Fusarium solani IMI196840 (2010)
DockVis: Visual Analysis of Molecular Docking Trajectories (2020)
Engineering of bacterial strains for degradation of environmental pollutants by synthetic biology (2018)
Engineering of enzyme gating driven by molecular dynamics, transient kinetics, and single molecule spectroscopy (2018)
Analyzer for Fluorescent Biosensing Application (2011)
DESIGNING RECOMBINANT MAIZE beta-GLUCOSIDASE Zm-p60.1: DEVELOPMENT OF NOVEL ENZYMES MODULATING CYTOKININ METABOLISM (2010)
Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1 (2020)
Current status and future perspectives of fibroblast growth factor 2 in wound healing (2020)
Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst (2020)
EnzymeMiner: automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities (2020)
A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability (2020)
Exploration of enzyme diversity: High-throughput techniques for protein production and microscale biochemical characterization (2020)
Online English for International Mobilities: A course for students (2020)
Fostering autonomy in learners with special needs: a specialized e-learning course (2020)
Seminář pro učitele angličtiny pracující s neslyšícími a nedoslýchavými studenty (2020)
Surface-enhanced Raman Spectroscopy in Microfluidic Chips for Directed Evolution of Enzymes and Environmental Monitoring (2019)
Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin (2020)
Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data (2021)
The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step (2020)
Fluorescent substrates for haloalkane dehalogenases: Novel probes for mechanistic studies and protein labeling (2020)
Multi-pathogen infections and Alzheimer's disease (2021)
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics (2020)
Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family (2020)
Simulation of Ligand Transport in Receptors Using CaverDock (2021)
Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance (2021)
Thermostable FGF2 Polypeptide, Use Thereof (2021)
Development and Testing of Thrombolytics in Stroke (2021)
Promiscuous Dehalogenase Activity of the Epoxide Hydrolase CorEH from Corynebacterium sp. C12 (2021)
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (2019)
Collagen/Chitosan dermal substitute enriched by hyperstable FGF2, 4 years of development (2021)
FireProt(DB): database of manually curated protein stability data (2021)
Description of Transport Tunnel in Haloalkane Dehalogenase Variant LinB D147C+L177C from Sphingobium japonicum (2021)
Substrate Anchoring and Flexibility Reduction in CYP153A(M.aq) Leads to Highly Improved Efficiency toward Octanoic Acid (2021)
Substrate inhibition by the blockage of product release and its control by tunnel engineering (2021)
The tetrameric structure of the novel haloalkane dehalogenase DpaA from Paraglaciecola agarilytica NO2 (2021)
Computational design of enzymes for biotechnological applications (2021)
SoluProt: prediction of soluble protein expression in Escherichia coli (2021)
Exploring mechanism of enzyme catalysis by on-chip transient kinetics coupled with global data analysis and molecular modeling (2021)
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors (2021)
Screening of world approved drugs against highly dynamical spike glycoprotein of SARS-CoV-2 using CaverDock and machine learning (2021)
Engineering the protein dynamics of an ancestral luciferase (2021)
Web-based tools for computational enzyme design (2021)
Stabilization of Haloalkane Dehalogenase Structure by Interfacial Interaction with Ionic Liquids (2021)
Vývoj dermální náhrady, kvalitativní testování na zvířecích modelech (2021)
Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells (2022)
Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers (2021)
FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction (2021)
Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA (2021)
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES (2021)
Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi (2021)
Thermostable FGF2 polypeptide, use thereof (2021)
PDBe-KB: collaboratively defining the biological context of structural data (2022)
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin (2022)
Deep Insights into the Specific Evolution of Fungal Hybrid B Heme Peroxidases (2022)
Tools for computational design and high-throughput screening of therapeutic enzymes (2022)
Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase (2022)
Mechanism-Based Design of Efficient PET Hydrolases (2022)
Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase (2021)
Computational enzyme design for metabolic engineering (2021)
Fast approximative methods for study of ligand transport and rational design of improved enzymes for biotechnologies (2022)
LoopGrafter: a web tool for transplanting dynamical loops for protein engineering (2022)
A Nonconventional Archaeal Fluorinase Identified by In SilicoMining for Enhanced Fluorine Biocatalysis br (2022)
CalFitter 2.0: Leveraging the power of singular value decomposition to analyse protein thermostability (2022)
Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling (2022)
Mechanism-guided tunnel engineering to increase the efficiency of a flavin-dependent halogenase (2022)
IMPACT OF ADMINISTRATION METHOD OF THROMBOLYTICS ON THEIR THROMBOLYTIC EFFECTS (2022)
Engineering CYP153A(M.aq) to Oxyfunctionalize its Inhibitor Dodecylamine Using a LC/MS Based Rapid Flow Analysis Screening (2022)
Modelling of a rare mutation in the GALNT3 gene found in patient with teeth and bone defects using genetically engineered mice (2022)
sMolBoxes: Dataflow Model for Molecular Dynamics Exploration (2023)
Geometric Control of Cell Behavior by Biomolecule Nanodistribution (2022)
Caver Web 1.2 (2022)
MAPityser 2.1 - Analyzátor dat pro mikrofluidní platformu MAPit (2022)
MicroPEX Data Analyser 1.0* (2022)
PredictSNP Onco 1.0 (2022)
SoluProtMutDB: A manually curated database of protein solubility changes upon mutations (2022)
Fully automated virtual screening pipeline of FDA-approved drugs using Caver Web (2022)
Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization (2022)
Virtual screening of potential anticancer drugs based on microbial products (2022)
Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease (2022)
Substituted aminothiazoles as inhibitors of nucleases (2022)
Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase (2022)
The future for the application of fibroblast growth factor 2 in modern wound healing (2023)
Advanced database mining of efficient haloalkane dehalogenases by sequence and structure bioinformatics and microfluidics (2022)
Droplet-Based Microfluidic Temperature-Jump Platform for the Rapid Assessment of Biomolecular Kinetics (2022)
ヌクレアーゼの阻害剤としての置換アミノチアゾール (2022)
Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus (2023)
Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase (2022)
熱安定性ＦＧＦ２ポリペプチド及びその使用 (2022)
Nástroj LoopGrafter (2022)
Substituted aminothiazoles as inhibitors of nucleases (2023)
Thermostable FGF2 polypeptide, use thereof (2023)
Catalytic mechanism for Renilla-type luciferases (2023)
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate (2023)
In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning (2023)
Identification, characterization, and engineering of glycosylation in thrombolytics (2023)
pyCaverDock: Python implementation of the popular tool for analysis of ligand transport with advanced caching and batch calculation support (2023)
Poměr plazminogen/plazmin jako ukazatel bezpečnosti trombolytické léčby (2023)
Stable Fibroblast Growth Factor 2 and its role in research from dermal regeneration to total skin substitute (2023)
SBILib: a handle for protein modeling and engineering (2023)
Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues (2023)
Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning (2023)
Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography (2023)
ChannelsDB 2.0: A Comprehensive Database of Protein Tunnels and Pores in AlphaFold Era (2023)
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase (2023)
InVADo: Interactive Visual Analysis of Molecular Docking Data (2024)
ChannelsDB 2.0: a comprehensive database of protein tunnels and pores in AlphaFold era (2024)
PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning (2024)
FireProt 2.0: web-based platform for the fully automated design of thermostable proteins (2024)
Substituted aminothiazoles as inhibitors of nucleases (2023)
Thermostable FGF2 polypeptide, use thereof (2023)
The SAP domain of Ku facilitates its efficient loading onto DNA ends (2023)
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum (2023)
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase (2023)
Computer-assisted stabilization of fibroblast growth factor FGF-18 (2023)
Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes (2024)
Machine Learning-Guided Protein Engineering (2023)
Study of Protein Conformational Dynamics Using Hydrogen/Deuterium Exchange Mass Spectrometry (2023)
Fully Automated Ancestral Sequence Reconstruction using FireProtASR (2021)
Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone (2024)
Computer-aided engineering of stabilized fibroblast growth factor 21 (2024)
Thermostable FGF2 Polypeptide, Use Thereof (2023)
Learning to design protein-protein interactions with enhanced generalization (2024)
Revealing data leakage in protein interaction benchmarks (2024)
Evaluation of viscoelastic parameters and photo-based assessment of newly developed dermal substitutes modified with thermostabilized fibroblast growth factor 2 (2024)
Visual Support for the Loop Grafting Workflow on Proteins (2024)
A computational workflow for analysis of missense mutations in precision oncology (2024)
CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules (2024)
AggreProt: a web server for predicting and engineering aggregation prone regions in proteins (2024)
Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family (2024)
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension (2024)
BenchStab: A tool for automated querying of web-based stability predictors (2024)
Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA (2024)
IDENTIFICATION OF NOVEL CYTOKININS BY MOLECULAR DOCKING (2024)
Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes (2024)

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