Publication Records

Selected publication/outcome records

Screeningové hodnocení environmentálních rizik v sedimentech regionu Zlín (2000)
Hodnocení biodostupnosti organických látek půdním mikroorganismům kontaktními testy toxicity (2000)
The use of a microbial contact toxicity test for evaluating cadmium bioavailability in soil (2001)
Bioavailability and mobility of organic contaminants in soil and sediment samples: a three-step ecotoxicology evaluation (2001)
Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product and water mediated inhibition (2002)
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis (2002)
Re-construction of mycobacterial dehalogenase Rv2579 by cumulative mutagenesis of haloalkane dehalogenase LinB (2003)
Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates (2003)
Catalytic mechanism of the haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 (2003)
Validation of Putative Enzymes from Genomic Projects: Confirmation of Dehalogenation ARv2ctivity for Mycobacterial Protein 579 (2003)
Modification of Activity and Specificity of Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26 by Engineering of its Entrance Tunnel (2003)
Mobility, bioavailability and toxic effects of cadmium in soil samples. (2003)
Substrátová specifita haloalkandehalogenáz (2004)
Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26. (2005)
Development of a microtiter plate-based method for determination of degradation profile of nitrophenolic compounds (2006)
Two Rhizobial Strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, Encode Haloalkane Dehalogenases with Novel Structures and Substrate Specificities (2005)
Mycobacterial Haloalkane Dehalogenases: Cloning, Biochemical Properties and distribution. (2005)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2005)
Způsob detoxikace sulfidického yperitu psobením halogenalkandehalogenázami (2005)
Vývoj enzymového biosenzoru pro detekci chlorovaných pesticidů (2005)
Navržení Biosenzoru pro detekci chlorovaných pesticidů (2006)
Elektrochemické stanovení chloridů na uhlíkových elektrodách (2006)
Enzymový Biosenzor pro detekci chlorovaných pesticidů (2006)
Analýza chlorovaných uhlovodíků s využitím stříbrné a uhlíkové pastové elektrody (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides (2006)
Vyvoj enzymoveho biosenzoru pro detekci chlorovanych pesticidu (2006)
High-throughput characterization of enzymes from genomic and proteomic projects-multivariate statistical approach (2006)
Protein engineering of haloalkane dehalogenase LinB: reconstruction of active site and modification of entrance tunnel (2006)
Expression of Glycosylated Haloalkane Dehalogenase LinB in Pichia pastoris. (2006)
Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. (2007)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2006)
Enzymes Fight Chemicals Weapons. (2006)
Development of biosensor for determination of chlorinated pesticides. (2006)
Engineering of enantioselective enzyme by cumulative mutagenesis. (2006)
A suggestion of enzymatic biosensor for determination of chlorinated pesticides. (2006)
Solvent Isotope Effects on Haloalkane Dehalogenase LinB. (2006)
Physical Variables as a Control of Enzyme Stereoselectivity (2006)
Engineering of Enantioselective Haloalkane Dehalogenase by Cumulative Mutagenesis (2006)
Discovery of Stereoselective Haloalkane Dehalogenases: New Tool for Asymmetric Syntheses. (2006)
Expression of Haloalkane Dehalogenase LinB in Pichia pastoris (2006)
Development of Enzymatic Biosensor for Determination of Chlorinated Pesticides (2006)
Řízení stereoselektivity enzymu fyzikálně-chemickými parametry (2006)
Natural and Engineered Enantioselective Haloalkane Dehalogenases (2006)
Structure-Based Engineering of Haloalkane Dehalogenase (2006)
Engineering of Haloalkane Dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 Towards Higher Enantioselectivity (2006)
The stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of Temperature and pH (2006)
The Identification of Catalytic Pentad in the Haloalkane Dehalogenase DhmA from Mycobacterium avium N85: Reaction Mechanism and Molecular Evolution (2007)
Characterization of Haloalkane Dehalogenases DrbA and DmbC: Representatives of Novel Subfamily. (2009)
Degradation of Beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Hexachlorocyclohexane-Utilizing Bacterium Sphingobium sp. MI1205 (2007)
Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-ray Crystallography and Microcalorimetry (2007)
Degradation of 4 Nitroguaiacol and Other Nitroaromatic Compounds by Strains of Arthrobacter nitroguajacolicus. (2007)
Enzymatic reaction coupled with flow-injection analysis with charged aerosol, coulometric, or amperometric detection for estimation of contamination of the environment by pesticides (2008)
Degradation of 4 Nitroguaiacol and Other Nitroaromatic Compounds by Strains of Arthrobacter nitroguajacolicus. (2008)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The effect of temperature and pH (2007)
Haloalkane Dehalogenases Possess Two Different Structural Bases for Their Enantioselectivity (2007)
Comparative Binding Energy (COMBINE) Analysis of the Substrate Specificity of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110. (2007)
Keyhole-Lock-Key Model of Enzymatic Catalysis: Engineering of Tunnels in Proteins with Buried Active Sites (2007)
Změna enantioselektivity a substrátové specifity haloalkan dehalogenázy proteinovým inženýrstvím (2007)
Comparative Binding Energy Analysis of Haloalkane Dehalogenase from Bradyrhizobium japonicum USDA110 (2007)
Development of Enzymatic Biosensors for Detection of Halogenated Environmental Pollutants (2007)
Stereoselektivita a konformační stabilita halogenalkan dehalogenázy DbjA z Bradyrhizobium japonicum USDA110, (2007)
Využití enzymů ve farmaceutických výrobách (2007)
Enzymatic Detoxification of Sulfur Mustard by Haloalkane Dehalogenases (2007)
LinB Enzyme for Detection of Chlorinated Pesticides- Suggestion Design of a New Biosensor (2007)
Protein Engineering of Haloalkane Dehalogenases: Towards the Change of Reaction Mechanism (2008)
Development of Enzyme Biosensors for Detection of Toxic Halogenated Compounds (2008)
Semi-Rational Engineering of Haloalkane Dehalogenases DHAA Towards Improved Activity with 1,2-Dichloroethane (2008)
Quantitative Comparison of Binding Sites within the Protein Family of Haloalkane Dehalogenases, (2008)
Characterization of Haloalkane Dehalogenase DmbC from Mycobacterium tubercul.sis H37Rv, (2008)
Inženýrství stereoselektivity enzymů pro aplikace biokatalýzy (2008)
Modulation of Enantioselectivity in Haloalkane Dehalogenase DbjA by Engineering of a Surface Loop (2008)
Thermodynamic Analysis of Enantioselectivity of Haloalkane Dehalogenase DbjA and its Variants DbjA and DbjA+H139A towards Brominated Esters and substituted Bromoalkanes (2008)
Determination of capsidiol in tobacco cells culture by HPLC (2010)
Decontamination of chemical warfare agent sulphur mustard (2008)
Recombinant enzyme haloalkane dehalogenase LinB (2008)
Recombinant enzyme haloalkane dehalogenase DhaA (2008)
Recombinant enzyme haloalkane dehalogenase DbjA (2008)
Recombinant enzyme haloalkane dehalogenase DmbA (2008)
Recombinant enzyme haloalkane dehalogenase DhmA (2008)
Recombinant enzyme haloalkane dehalogenase DmbB (2008)
Recombinant enzyme haloalkane dehalogenase DmbC (2009)
Recombinant enzyme haloalkane dehalogenase DrbA (2009)
Recombinant enzyme haloalkane dehalogenase DbeA (2009)
Fluorescence spectrophotometer TUH-01 (2008)
Pathways and Mechanisms for Product Release in the Engineered Haloalkane Dehalogenases Explored using Classical and Random Acceleration Molecular Dynamics Simulations. (2009)
Chiral Aliphatic Hydroxy Compounds in Nature: a Review of Biological Functions and Practical Applications. (2009)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2007)
Early Warning Biosensors for Detection of Chemical Warfare Agents. (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
Development of an enzymatic fiber-optic biosensor for detection of halogenated hydrocarbons. (2010)
Biochemical and structural characterization of novel haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94 possesing two halide binding sites (2010)
Effect of organic solvents on structure and function of haloalkane dehalogenases (2010)
Engineering of Enzymes by Modification of Access Tunnels (2010)
Engineering of Biocatalysts by Modification of Access Tunnels (2010)
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)
CONSTRUCTION AND CHARACTERIZATION OF FIBER-OPTIC BIOSENSOR BASED ON HALOALKANE DEHALOGENASE (2010)
Optical biosensor based on haloalkane dehalogenase for detection of halogenated hydrocarbons in the environment. (2010)
Struktura a funkce haloalkándehalogenas v organických rozpouštědlech (2010)
Haloalkane dehalogenase from Agrobacterium tumefaciens C58 with new halide-stabilising residues and unique kinetics (2010)
Investigation of Ligand Passage in Proteins Investigation of Ligand Passage in Proteins (2010)
Kinetics and enantioselectivity of haloalkane dehalogenase from Agrobacterium tumefaciens c58 (2010)
Biology and Bioinformatics (2011)
Construction of pollutant-degrading bacteria by protein and metabolic engineering (2011)
In vitro protein and metabolic engineering of a biodegradation pathway (2011)
Molecular bases of enantioselectivity of haloalkane dehalogenase DbjA. (2011)
Stereoselectivity and Conformational Stability of Haloalkane Dehalogenase DbjA from Bradyrhizobium japonicum USDA110: The Effect of pH and Temperature. (2011)
Biochemical Characteristics of the Novel Haloalkane Dehalogenase DatA Isolated from the Plant Pathogen Agrobacterium tumefaciens C58. (2011)
Biodegradation of 1,2,3-Trichloropropane (2011)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
Molecular mechanisms of the effects of organic solvents on activity of haloalkane dehalogenases (2011)
Molekulární podstata působení organických rozpouštědel na strukturu a funkci haloalkandehalogenáz (2011)
Decontamination kit Yperzyme (2011)
Recombinant enzyme haloalkane dehalogenase DmxA (2011)
Recombinant enzyme haloalkane dehalogenase Spur (2011)
Recombinant enzyme haloalkane dehalogenase DpcA (2011)
Sphingobium czechense LL01 sp. nov (2011)
Novosphingobium barchaimii LL02 sp. nov (2011)
Sphingobium baderi LL03 sp. nov (2011)
Fluorimetr pro biosensorové měření (2011)
HaloPen (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
ZPŮSOB DETOXIKACE SULFIDICKÉHO YPERITU ÚČINKEM HALOGENALKANDEHALOGENÁZ (2007)
Method of Production of Optically Active Hydrocarbons and Alcohols Using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. (2009)
A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB (2012)
Conjugation of 5(6)-carboxyfluorescein and 5(6)-carboxynaphthfluorescein with bovine serum albumin and their immobilization for optical pH sensing (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA57 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA61 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA63 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA80 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA82 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA85 (2012)
Engineered recombinant enzyme haloalkane dehalogenase DhaA88 (2012)
Haloalkane dehalogenases: Biotechnological applications (2013)
Expansion of Access Tunnels and Active-Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents. (2013)
The Effect of a Unique Halide-Stabilising Residue on the Catalytic Properties of Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 (2013)
Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel (2013)
Sphingobium czechense sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Novosphingobium barchaimii sp nov., isolated from hexachlorocyclohexane-contaminated soil (2013)
Sphingobium baderi sp nov., isolated from a hexachlorocyclohexane dump site (2013)
Immobilization of Haloalkane Dehalogenase LinB from Sphingobium japonicum UT26 for Biotechnological Applications (2013)
Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents (2013)
Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations. (2013)
Způsob výroby opticky aktivních halogenalkanů a alkoholů hydrolytickou dehalogenací katalyzovanou halogenalkandehalogenázami (2009)
Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents (2013)
Method of detoxication of yperite by using haloalkane dehalogenases (2009)
Method of detoxication of yperite by using haloalkane dehalogenases (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2010)
Method of detoxication of yperite by using haloalkane dehalogenases, (2011)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2012)
Method of detoxication of yperite by using haloalkane dehalogenases (2013)
Miniaturizovaný příruční fluorimetr (2013)
E. coli degWT upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli degWT-opt- upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg90R-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31 upravená bakterie degradující toxické environmentální polutanty. (2013)
E. coli deg31-opt upravená bakterie degradující toxické environmentální polutanty. (2013)
Rekombinantní enzym haloalkan dehalogenáza DatA. (2013)
Rekombinantní enzym haloalkan dehalogenáza DspA. (2013)
CAVER Analyst 1.0: Graphic tool for interactive visualization and analysis of tunnels and channels in protein structures (2014)
Stepwise Enhancement of Catalytic Performance of Haloalkane Dehalogenase LinB towards Beta-Hexachlorocyclohexane. (2014)
Maximizing the Efficiency of Multi-enzyme Process by Stoichiometry Optimization. (2014)
Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane. (2014)
Structural and Functional Analysis of a Novel Haloalkane Dehalogenase with Two Halide-Binding Sites. (2014)
Microscopic Monitoring Provides Information on Structure and Properties During Biocatalyst Immobilisation. (2014)
Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design. (2014)
Computer-Assisted Engineering of Synthetic Pathway for Biodegradation of Toxic Persistent Pollutant. (2014)
Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets (2015)
Rekombinantní enzym haloalkane dehalogenase HTS001 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS003 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS004 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS005 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS010 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS006 (2014)
Rekombinantní enzym haloalkane dehalogenase HTS013 (2014)
Geneticky modifikovaná bakterie degradující toxické environmentalní polutanty Ps. putida CF4 deg31 (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 deg 31 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na chromosomu (2014)
Geneticky modifikovaná bakterie Pseudomonas putida CF4 pro degradaci toxického environmentálního polutantu 1,2,3-trichlorpropanu na plasmidu. (2014)
Caver Analyst 1.0 (2014)
Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence. (2015)
Balancing the Stability-Activity Trade-off by Fine-Tuning Dehalogenase Access Tunnels. (2015)
Exacerbation of Substrate Toxicity by IPTG in Escherichia coli BL21(DE3) Carrying a Synthetic Metabolic Pathway (2015)
Bioavailability and mobility of organic contaminants in soil: new three-step ecotoxicological evaluation (2016)
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants (2015)
Novel LinA Type 3 delta-Hexachlorocyclohexane Dehydrochlorinase (2015)
Mechanism-Based Discovery of Novel Substrates of Haloalkane Dehalogenases using in Silico Screening (2015)
Detekční proužky (2015)
DsvA from Saccharomonospora viridis DSM 43017 (2015)
Enzyme haloalkane dehalogenase DmxA from Marinobacter sp. ELB17 purified to homogeneity (2015)
Recombinant ancestral enzyme ancHLD-Rluc (2015)
Recombinant ancestral enzyme ancLinB-DmbA (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD1 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD2 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD3 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD4 (2015)
Recombinant ancestral enzyme ancDbjA-DbeA NOD5 (2015)
Device for Detection of Halogenated Hydrocarbons (2016)
Thermostable FGF2 Polypeptide, Use Thereof (2020)
Firmware k ovládání biosensoru (2015)
Accelerated Visualization of Transparent Molecular Surfaces in Molecular Dynamics (2016)
Imunosensory pro rychlou detekci patogenních mikroorganismů (2016)
Discovery of Novel Haloalkane Dehalogenase Inhibitors (2016)
Rapid Immunosensing of Salmonella Typhimurium Using Electrochemical Impedance Spectroscopy: the Effect of Sample Treatment (2016)
Interactive Exploration of Ligand Transportation through Protein Tunnels (2017)
Gelatin-templated Nanostructured Gold for Electrochemical Detection of Glucose in Serum (2016)
The Dynamics of Xylem Sap pH under Drought: a Universal Response in Herbs? (2016)
Engineering a de Novo Transport Tunnel (2016)
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions (2016)
HotSpot Wizard 2.0: Automated Design of Site-Specific Mutations and Smart Libraries in Protein Engineering (2016)
Enzyme Based Test Stripes for the Visual or Photographic Detection and Quantitation of Gaseous Sulfur Mustard (2016)
Fluorescence-Based Biosensor for Monitoring of Environmental Pollutants: From Concept to Field Application. (2016)
Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB (2016)
Mikrofluidní čip pro teplotní gradient (2016)
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging (2017)
Individuální rozdíly v učení se cizím jazykům: specifická situace neslyšících (2017)
Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges (2017)
Watergate: Visual Exploration of Water Trajectories in Protein Dynamics (2017)
Immunosensors for detection of pathogenic bacteria (2017)
CaverDock 1.0 (2017)
Recombinant enzyme haloalkane dehalogenase LinB116 carrying thermostabilizing mutations by FRESCO with removed disulphide bridge. (2017)
Biosensorická špička s DgpA pro detekci v nízké teplotě 10 oC (2017)
Biosensorická špička s DhmeA pro detekci v alkalických podmínkách pH 10 (2017)
Biosensorická špička s LinA a LinB pro detekci beta-HCH (2017)
Recombinant enzyme gamma-hexachlorocyclohexane dehydrochlorinase LinA01 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA101 carrying thermostabilizing mutations by evolution-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA112 carrying thermostabilizing mutations by energy-based approach (2017)
Recombinant enzyme haloalkane dehalogenase DhaA115 carrying thermostabilizing mutations by combine approach (2017)
Recombinant enzyme halohydrin dehalogenase HheC01 carrying thermostabilizing mutations (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT01 carrying thermostabilizing mutations. (2017)
Recombinant enzyme halohydrin dehalogenase HheC-LT02 carrying thermostabilizing mutations. (2017)
Recombinant enzyme haloalkane dehalogenase eHLD2 (2017)
Recombinant enzyme haloalkane dehalogenase eHLD3 (2017)
HTS 1.0 (2017)
Recombinant enzyme halohydrin dehalogenase HheC-DJ carrying thermostabilizing mutations. (2017)
A Haloalkane Dehalogenase From a Marine Microbial Consortium Possessing Exceptionally Broad Substrate Specificity (2018)
Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating (2017)
Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets (2017)
Metagenome-derived Haloalkane Dehalogenases with Novel Catalytic Properties (2017)
NewProt – a Protein Engineering Portal (2017)
Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (2017)
Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open–Solvated versus Occluded–Desolvated Active Sites (2017)
FireProt: Web Server for Automated Design of Thermostable Proteins (2017)
Kinetics of Binding of Fluorescent Ligands to Enzymes with Engineered Access Tunnels (2017)
Structure-function Relationships and Engineering of Haloalkane Dehalogenases. (2017)
Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling (2017)
Enzyme Tunnels and Gates As Relevant Targets in Drug Design (2017)
Protection of Arabidopsis Blunt-Ended Telomeres Is Mediated by a Physical Association with the Ku Heterodimer (2017)
High-throughput screening of haloalkane dehalogenase libraries based on a pH- sensitive assay using droplet-based microfluidics (2017)
FireProt 1.0 (2017)
CalFitter 1.0 (2017)
NewProt 1.0 (2017)
Computational Enzyme Design of Haloalkane Dehalogenases for Yperite Degradation (2018)
Impact of the access tunnel engineering on catalysis is strictly ligand-specific (2018)
Computer-assisted engineering of hyperstable fibroblast growth factor 2 (2018)
Sampling-based Motion Planning for Tracking Evolution of Dynamic Tunnels in Molecular Dynamics Simulations (2019)
CAVER Analyst 2.0: Analysis and Visualization of Channels and Tunnels in Protein Structures and Molecular Dynamics Trajectories (2018)
Academic mobilities of students with hearing impairment: Welcoming the challenges with specialized online course of written English (2018)
Visual Analysis of Ligand Trajectories in Molecular Dynamics (2019)
14th ESSE Conference (2018)
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing (2018)
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants (2018)
Isoform-selective HDAC1/16/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity (2018)
Molecular Gating of an Engineered Enzyme Captured in Real Time (2018)
Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips (2018)
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization (2018)
Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site (2018)
CalFitter: a web server for analysis of protein thermal denaturation data (2018)
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information (2018)
Sensitive operation of enzyme-based biodevices by advanced signal processing (2018)
Haloalkane Dehalogenases From Marine Organisms (2018)
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization (2018)
CaverDock: A Novel Method for the Fast Analysis of Ligand Transport (2020)
Bilaminární kožní dermální náhrada: Vliv stabilního FGF2 na kapilární denzitu sledovanou pomocí modelů ex-ovo a in vivo (2019)
Analysis of Long Molecular Dynamics Simulations Using Interactive Focus+Context Visualization (2019)
Stable fibroblast growth factors in burn medicine research (2019)
Gastrointestinální stromální tumory rekta - hodnocení dat národního registru s ohledem na využití v klinické praxi (2019)
Development of an innovative nanostructured dermal matrix in combination with a hyperstable form of growth factor for fibroblasts (FGF2): Ex ovo and in vivo study (2019)
CaverDock: a molecular docking-based tool to analyse ligand transport through protein tunnels and channels (2019)
Caver Web 1.0: identification of tunnels and channels in proteins and analysis of ligand transport (2019)
Structural Biology and Protein Engineering of Thrombolytics (2019)
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts (2019)
Fluorescent pH Indicators for Neutral to Near-Alkaline Conditions Based on 9-Iminopyronin Derivatives (2019)
Collagen-based dermal substitute with stable fibroblast growth factor 2 (FGF2): ex ovo and in vivo impact on neovascularization (2019)
Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics (2019)
New collagen foam with nanotechnological modification as bi-layer dermal substitute: Influence of stable FGF2 on capillary density in different animal models (2019)
Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway (2019)
Testování bilaminární kožní náhrady obohacené stabilním FGF2 na ex ovo a in vivo modelech (2019)
Fast Screening of Inhibitor Binding/Unbinding using Novel Software Tool CaverDock (2019)
Nanopatterning Glass Surface For Localization Of Embryonic Stem Cells (2019)
Deaf learners' processing of English textbook material : An eye-tracking study (2020)
Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics (2019)
A benchmark set of highly-efficient CUDA and OpenCL kernels and its dynamic autotuning with Kernel Tuning Toolkit (2020)
Computational Study of Protein-Ligand Unbinding for Enzyme Engineering (2019)
Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase (2019)
Development of Fluorescent Assay for Monitoring of Dehalogenase Activity (2019)
Computational Design of Stable and Soluble Biocatalysts (2019)
Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5 (2019)
Transhalogenation Catalysed by Haloalkane Dehalogenases Engineered to Stop Natural Pathway at Intermediate (2019)
Engineering enzyme access tunnels (2019)
Crystallization and Crystallographic Analysis of a Bradyrhizobium Elkanii USDA94 Haloalkane Dehalogenase Variant with an Eliminated Halide-Binding Site (2019)
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity (2019)
Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17 (2019)
An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation (2020)
Machine Learning in Enzyme Engineering (2020)
ACCELERATION AND GLOBAL CONVERGENCE OF A FIRST-ORDER PRIMAL-DUAL METHOD FOR NONCONVEX PROBLEMS (2019)
OPTOFLUIDIC TECHNIQUES FOR DIRECTED EVOLUTION OF ENZYMES (2018)
Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips (2018)
Foreign Language Learning Experiences of Deaf and Severely Hard-of-Hearing Czech University Students (2019)
Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor (2019)
Caver web: identification of tunnels and channels in proteins and analysis of ligand transport (2019)
DockVis: Visual Analysis of Molecular Docking Trajectories (2020)
Engineering of enzyme gating driven by molecular dynamics, transient kinetics, and single molecule spectroscopy (2018)
Transcription and Translation Inhibitors in Cancer Treatment (2020)
Exploiting historical data: Pruning autotuning spaces and estimating the number of tuning steps (2020)
Analyzer for Fluorescent Biosensing Application (2011)
ChemVA: Interactive Visual Analysis of Chemical Compound Similarity in Virtual Screening (2021)
Exploring Protein Folding Space with Neural Network Guided Simulations (2020)
Primal-Dual Proximal Splitting and Generalized Conjugation in Non-smooth Non-convex Optimization (2021)
Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst (2020)
EnzymeMiner: automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities (2020)
A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability (2020)
Predicting protein stability and solubility changes upon mutations: data perspective (2020)
Exploration of enzyme diversity: High-throughput techniques for protein production and microscale biochemical characterization (2020)
Epidemiology typing and molecular analysis of vancomycin-resistant Enterococcus foeclum in haemato-oncological patients. (2020)
Online English for International Mobilities: A course for students (2020)
Fostering autonomy in learners with special needs: a specialized e-learning course (2020)
Seminář pro učitele angličtiny pracující s neslyšícími a nedoslýchavými studenty (2020)
Surface-enhanced Raman Spectroscopy in Microfluidic Chips for Directed Evolution of Enzymes and Environmental Monitoring (2019)
The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step (2020)
Fluorescent substrates for haloalkane dehalogenases: Novel probes for mechanistic studies and protein labeling (2020)
Multi-pathogen infections and Alzheimer's disease (2021)
Primal-dual block-proximal splitting for a class of non-convex problems (2020)
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics (2020)
Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family (2020)
4D-GRAPHS (2021)
Simulation of Ligand Transport in Receptors Using CaverDock (2021)
Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance (2021)
Thermostable FGF2 Polypeptide, Use Thereof (2021)
Development and Testing of Thrombolytics in Stroke (2021)
Promiscuous Dehalogenase Activity of the Epoxide Hydrolase CorEH from Corynebacterium sp. C12 (2021)
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (2019)
Collagen/Chitosan dermal substitute enriched by hyperstable FGF2, 4 years of development (2021)
FireProt(DB): database of manually curated protein stability data (2021)
Description of Transport Tunnel in Haloalkane Dehalogenase Variant LinB D147C+L177C from Sphingobium japonicum (2021)
Substrate Anchoring and Flexibility Reduction in CYP153A(M.aq) Leads to Highly Improved Efficiency toward Octanoic Acid (2021)
Substrate inhibition by the blockage of product release and its control by tunnel engineering (2021)
The tetrameric structure of the novel haloalkane dehalogenase DpaA from Paraglaciecola agarilytica NO2 (2021)
Computational design of enzymes for biotechnological applications (2021)
SoluProt: prediction of soluble protein expression in Escherichia coli (2021)
Kernel Tuning Toolkit 2.0 (2021)
Exploring mechanism of enzyme catalysis by on-chip transient kinetics coupled with global data analysis and molecular modeling (2021)
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors (2021)
VRdeo: Creating engaging educational material for asynchronous student-teacher exchange using virtual reality (2021)
Screening of world approved drugs against highly dynamical spike glycoprotein of SARS-CoV-2 using CaverDock and machine learning (2021)
Using hardware performance counters to speed up autotuning convergence on GPUs (2022)
Engineering the protein dynamics of an ancestral luciferase (2021)
Web-based tools for computational enzyme design (2021)
Stabilization of Haloalkane Dehalogenase Structure by Interfacial Interaction with Ionic Liquids (2021)
Searching CUDA code autotuning spaces with hardware performance counters: data from benchmarks running on various GPU architectures (2021)
Vývoj dermální náhrady, kvalitativní testování na zvířecích modelech (2021)
Úskalí laboratorních metod v ovariálním skríninku - doba "-omická"? (2020)
The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination (2021)
Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers (2021)
FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction (2021)
Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA (2021)
Complex simulation workflows in containerized high-performance environment (2021)
Property Map Collective Variable as a Useful Tool for a Force Field Correction (2022)
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2 (2021)
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES (2021)
Vliv IFITM1 na „surfaceom“ buněk cervikálního karcinomu (2021)
Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi (2021)
Thermostable FGF2 polypeptide, use thereof (2021)
Improving ligand transport trajectory within flexible receptor in CaverDock (2022)
PDBe-KB: collaboratively defining the biological context of structural data (2022)
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin (2022)
Deep Insights into the Specific Evolution of Fungal Hybrid B Heme Peroxidases (2022)
Tools for computational design and high-throughput screening of therapeutic enzymes (2022)
Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase (2022)
Mechanism-Based Design of Efficient PET Hydrolases (2022)
Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase (2021)
Computational enzyme design for metabolic engineering (2021)
Fast approximative methods for study of ligand transport and rational design of improved enzymes for biotechnologies (2022)
IFITM PROTEINS REGULATE IMMUNE-RELATED CELL SURFACE MOLECULES IN CERVICAL CARCINOMA (2022)
IFITM PROTEINS REGULATE SENSITIVITY OF CERVICAL CANCER CELLS TO CISPLATIN (2022)
LoopGrafter: a web tool for transplanting dynamical loops for protein engineering (2022)
A Nonconventional Archaeal Fluorinase Identified by In SilicoMining for Enhanced Fluorine Biocatalysis br (2022)
CalFitter 2.0: Leveraging the power of singular value decomposition to analyse protein thermostability (2022)
Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling (2022)
Mechanism-guided tunnel engineering to increase the efficiency of a flavin-dependent halogenase (2022)
IMPACT OF ADMINISTRATION METHOD OF THROMBOLYTICS ON THEIR THROMBOLYTIC EFFECTS (2022)
DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS (2022)
Engineering CYP153A(M.aq) to Oxyfunctionalize its Inhibitor Dodecylamine Using a LC/MS Based Rapid Flow Analysis Screening (2022)
sMolBoxes: Dataflow Model for Molecular Dynamics Exploration (2023)
Geometric Control of Cell Behavior by Biomolecule Nanodistribution (2022)
Caver Web 1.2 (2022)
MAPityser 2.1 - Analyzátor dat pro mikrofluidní platformu MAPit (2022)
MicroPEX Data Analyser 1.0* (2022)
PredictSNP Onco 1.0 (2022)
SoluProtMutDB: A manually curated database of protein solubility changes upon mutations (2022)
Fully automated virtual screening pipeline of FDA-approved drugs using Caver Web (2022)
Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization (2022)
Virtual screening of potential anticancer drugs based on microbial products (2022)
Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease (2022)
Follistatin-like 1 and its paralogs in heart development and cardiovascular disease (2022)
Substituted aminothiazoles as inhibitors of nucleases (2022)
Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase (2022)
The future for the application of fibroblast growth factor 2 in modern wound healing (2023)
Advanced database mining of efficient haloalkane dehalogenases by sequence and structure bioinformatics and microfluidics (2022)
Droplet-Based Microfluidic Temperature-Jump Platform for the Rapid Assessment of Biomolecular Kinetics (2022)
ヌクレアーゼの阻害剤としての置換アミノチアゾール (2022)
Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus (2023)
Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase (2022)
熱安定性ＦＧＦ２ポリペプチド及びその使用 (2022)
Nástroj LoopGrafter (2022)
Substituted aminothiazoles as inhibitors of nucleases (2023)
Thermostable FGF2 polypeptide, use thereof (2023)
Catalytic mechanism for Renilla-type luciferases (2023)
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate (2023)
Comparison of Fungal Thermophilic and Mesophilic Catalase-Peroxidases for Their Antioxidative Properties (2023)
In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning (2023)
Identification, characterization, and engineering of glycosylation in thrombolytics (2023)
pyCaverDock: Python implementation of the popular tool for analysis of ligand transport with advanced caching and batch calculation support (2023)
Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples (2024)
Poměr plazminogen/plazmin jako ukazatel bezpečnosti trombolytické léčby (2023)
Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues (2023)
Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning (2023)
In cellulo and in vivo assays for compound testing against Trypanosoma cruzi (2023)
Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography (2023)
ChannelsDB 2.0: A Comprehensive Database of Protein Tunnels and Pores in AlphaFold Era (2023)
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase (2023)
InVADo: Interactive Visual Analysis of Molecular Docking Data (2024)
ChannelsDB 2.0: a comprehensive database of protein tunnels and pores in AlphaFold era (2024)
PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning (2024)
FireProt 2.0: web-based platform for the fully automated design of thermostable proteins (2024)
Substituted aminothiazoles as inhibitors of nucleases (2023)
Thermostable FGF2 polypeptide, use thereof (2023)
The SAP domain of Ku facilitates its efficient loading onto DNA ends (2023)
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum (2023)
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase (2023)
Computer-assisted stabilization of fibroblast growth factor FGF-18 (2023)
Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes (2024)
Machine Learning-Guided Protein Engineering (2023)
Study of Protein Conformational Dynamics Using Hydrogen/Deuterium Exchange Mass Spectrometry (2023)
Fully Automated Ancestral Sequence Reconstruction using FireProtASR (2021)
Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone (2024)
Computer-aided engineering of stabilized fibroblast growth factor 21 (2024)
Thermostable FGF2 Polypeptide, Use Thereof (2023)
CRISPR CAS9 ENGINEERED TETRASPANIN DEFICIENT CELL LINES FOR THE ANALYSIS OF EXTRACELLULAR VESICLES (2023)
Learning to design protein-protein interactions with enhanced generalization (2024)
Revealing data leakage in protein interaction benchmarks (2024)
Special Issue on Artificial Intelligence for Synthetic Biology (2024)
Nano-enabled pesticides: a comprehensive toxicity assessment of tebuconazole nanoformulations with nematodes at single species and community level (2024)
N-glycan profiling of tissue samples to aid breast cancer subtyping (2024)
Investigation of long non-coding RNAs in extracellular vesicles from low-volume blood serum specimens of colorectal cancer patients (2024)
Changes of serum protein N-glycosylation in cancer (2022)
Determination of PPAR gamma agonistic activity of mimulone and diplacone in nanoparticle formulations (2024)
Visual Support for the Loop Grafting Workflow on Proteins (2024)
A computational workflow for analysis of missense mutations in precision oncology (2024)
GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening (2024)
CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules (2024)
AggreProt: a web server for predicting and engineering aggregation prone regions in proteins (2024)
Effects of three tebuconazole nanopesticides on the survival of <i>Daphnia magna</i> (2024)
Release and stability of two tebuconazole nanoformulations in different aquatic media (2024)
Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1 (2024)
Identification of new endocrine disruptive transthyretin ligands in polluted waters using pull-down assay coupled to non-target mass spectrometry (2024)
Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family (2024)
Lipidomic analysis of tetraspanin-deficient extracellular vesicles (2024)
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension (2024)
BenchStab: A tool for automated querying of web-based stability predictors (2024)
Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA (2024)
Lipidomic profiling of extracellular vesicles from tetraspanin-deficient cell lines (2024)
Proteomic analysis of tetraspanin-deficient extracellular vesicles (2024)
IDENTIFICATION OF NOVEL CYTOKININS BY MOLECULAR DOCKING (2024)
Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes (2024)

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