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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX (2007)
Analysis of MDM2 and MDMX domains involved in p53 ubiquitylation and degradation (2007)
Regulation of the P53 tumour suppressor protein by MDM2 and MDMX (2008)
Oncoproteins Mdm2 and MdmX: Their roles in the regulation of the p53 tumour suppressor protein (2009)
Identification and functional analysis of novel binding partners for oncoprotein Mdm2 (2009)
Analysis of Mdm2 domains involved in p53 degradation (2009)
Regulation of cellular stress response pathways by interactions between Mdm2 and transcription factor GTF2I (2009)
Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs (2010)
Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins (2009)
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use (2010)
Function analysis of two newly identified Mdm2-interacting proteins in cellular stress response pathways (2010)
Insight into the structural and functional differences of Mdm2 and MdmX RING finger domains (2010)
Identification and analysis of novel Mdm2/MdmX-interacting proteins involved in the regulation of the p53 tumour suppressor pathway (2010)
Small molecule inhibitors of cellular stress response pathways can modulate viability of malignant melanoma cells (2010)
Identification and analysis of two novel Mdm2-interacting proteins involved in the regulation of cellular stress response pathways (2010)
Identifikace nových vazebných partnerů pro onkoprotein Mdm2 a jejich vliv na regulaci Mdm2 a p53 v nádorových buňkách (2010)
Funkční analýza RING domén onkoproteinů mdm2 a MdmX (2010)
Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status (2011)
Benzo[c]phenanthridine alkaloids induce various types of cell death in cancer cells (2011)
The length of the extreme C-terminal tail of Mdm2 is critical for its activity towards p53 (2011)
Therapeutic potential of CDK inhibitor roscovitine in malignant melanoma (2011)
p38 MAPK - a promising target for metastatic melanoma therapy? (2011)
Role autofagie v cílené léčbě maligního melanomu (2011)
Potenciál kombinace negenotoxických látek SB202190 a gossypolu v cílené terapii maligního melanomu (2011)
Identification and functional analysis of novel binding partners for oncoprotein Mdm2 (2009)
Identifikace a funkční analýza nového regulátoru onkoproteinu Mdm2 (2011)
Studium vlivu délky C-koncové části onkoproteinu Mdm2 na jeho aktivitu vůči nádorovému supresoru p53 (2011)
Kombinace SB202190 a gossypolu významně snižuje viabilitu buněk maligního melanomu (2011)
Function analysis of newly identified regulator of oncoprotein Mdm2 (2011)
The conserved length of the C-terminal tail is essential for the activity of Mdm2 RING towards p53 (2011)
Benzo[c]phenanthridine alkaloids - compounds with high anti-proliferative activity against malignant melanoma (2011)
p38 MAPK - a potential target for metastatic melanoma therapy? (2011)
Function analysis of newly identified regulator of oncoprotein Mdm2 (2011)
The conserved length of the C-terminal tail is essential for the activitiy of Mdm2 RING towards p53 (2011)
Benzo[c]phenanthridine alkaloids - compounds with high anti-proliferative activity against malignant melanoma (2011)
p38 MAPK - a potential target for metastatic melanoma therapy? (2011)
P38 MAPK - a Potential Target for Metastatic Melanoma Therapy? (2011)
The two faces of FGF2 in metabolic pathway regulation in hESCs (2011)
Functional analysis of Mdm2 suggests differences between Mdm2 homodimers and Mdm2/MdmX heterodimers (2011)
FGF2 regulates the response of human embryonic stem cells to changes in metabolism (2011)
Benzo[c]phenanthridine alkaloids - compounds with high anti-proliferative activity against malignant melanoma (2011)
The conserved length of the C-terminal tail is essential for the activity of Mdm2 RING towards p53 (2011)
Benzo[c]phenanthridine Alkaloids - Compounds With High Anti-proliferative Activity Against Malignant Melanoma (2011)
Benzo[c]phenanthridine Alkaloids Induce Various Types of the Cell Death in Melanoma Cells (2011)
Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers (2012)
Metabolic changes in human embryonic stem cells are regulated by FGF2 (2012)
Function analysis of newly identified regulator of the MDM2-P53 pathway (2012)
Identification of differences in the primary structure of MDM2 and MDMX ring domains that render MDMX inactive (2012)
Sanguilutine induces caspase-independent type of cell death modulated by autophagy (2012)
P38 MAPK inhibitors cooperates with endoplasmic reticulum stress-inducing agents to promote apoptosis and modulate ERK pathway activity in melanoma cells (2012)
The glycolysis inhibitor 2-deoxy-D-glucose prmotes survival of melanoma cells through the activation of the adenylate cyclase/camp/PKA pathway (2012)
Salicylate and aspirin combined with PI3Ks inhibitor LY294002 or with natural pro-aptotic agent gossypol promote melanoma cell death (2012)
Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine (2012)
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability (2012)
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs (2013)
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex (2015)
Epigenetické reprogramování buněk vybraných neuroektodermálních nádorů (2014)
A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity (2015)
Evolution of the NSE1-NSE3-NSE4 subcomplex of the human SMC5/6 complex (2015)
Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux (2016)
Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity (2017)
Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma (2018)
A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein (2017)
Modulation of melanoma metabolism and viability with hexokinase and mitochondrial complex I inhibitors (2014)
Combination of mitochondrial oxidative phosphorylation and hexokinase inhibitors activates pro-survival pathways in melanoma (2013)
Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480 (2017)
Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization (2018)
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway (2019)
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells (2019)
A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize (2019)
BENZIMIDAZOLES DOWNREGULATE MDM2 AND MDMX AND ACTIVATE P53 IN MDMX OVEREXPRESSING TUMOR CELL (2019)
ALBENDAZOL A FENBENDAZOL SNIŽUJÍ EXPRESI MDM2 A MDMX A AKTIVUJÍ P53 V NÁDOROVÝCH LINIÍCH SE ZVÝŠENOU EXPRESÍ MDMX (2020)
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds (2020)
CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells (2020)
Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance (2021)
RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment (2021)
Lékařská biologie I. Buněčná a molekulární biologie (2022)
Kolaterálna cirkulácia zlepšuje rekanalizáciu pôsobením alteplázy: in vitro štúdia (2022)
Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture (2022)
Medical biology I. Cell and Molecular Biology (2022)
Lékařská biologie I. Buněčná a molekulární biologie (2023)
Lékařská biologie II. Genetika a molekulární medicína (2023)
Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis (2023)
A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset (2023)
Plazmatické hladiny FSTL1 a FSLT5 predikují obnovu funkce levé komory u pacientů s nově zjištěnou dilatační kardiomyopatií (2023)
Generation and validation of a high-throughput screening system for the identification of eIF4F inhibitors with anti-melanoma activity (2023)
A novel thrombocytopenia-4-causing CYCS gene variant decreases caspase activity: Three-generation study (2024)
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations (2024)
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