bp4061 Patophysiology of Exercise

Faculty of Sports Studies
autumn 2022
Extent and Intensity
1/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Martina Bernaciková, Ph.D. (lecturer), prof. MUDr. Jan Novotný, CSc. (deputy)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
MUDr. Kateřina Kapounková, Ph.D. (lecturer)
MUDr. Zdeněk Pospíšil (lecturer)
prof. MUDr. Jindřich Vomela, CSc., LL.M. (lecturer)
Mgr. Martina Bernaciková, Ph.D. (seminar tutor)
Mgr. Aleš Řehoř, Ph.D. (seminar tutor)
Mgr. Julie Linhartová (assistant)
Guaranteed by
prof. MUDr. Jindřich Vomela, CSc., LL.M.
Department of Health Promotion – Faculty of Sports Studies
Supplier department: Department of Health Promotion – Faculty of Sports Studies
Timetable
Mon 7:00–7:50 B11/206
  • Timetable of Seminar Groups:
bp4061/01: Mon 12:00–12:50 E34/225 - seminární místnost, M. Bernaciková
bp4061/02: Mon 11:00–11:50 E34/225 - seminární místnost, M. Bernaciková
bp4061/03: Tue 9:00–9:50 E34/225 - seminární místnost, M. Bernaciková
bp4061/04: Tue 8:00–8:50 E34/225 - seminární místnost, M. Bernaciková
Prerequisites (in Czech)
BOZP_OK(bozp_po_stud) && BOZP_OK(bozp_po_stud_fsps)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The graduate will be able to understand the basic physiological and pathological processes of people with sedentary lifestyles. The graduate will also be able to think creatively about the possible consequences of physical activity on the human body. Not only in the field of biological effects on individual systems, but also in the area of possible pathophysiological impact of regular specific sports load (both acute and chronic).
Learning outcomes
The graduate will be able to:
1. explain the issue of hypokinesis in relation to possible system changes of the organism and their health consequences
2. recommend basic stress and biochemical examinations in relation to possible weakness resulting from   hypokinesia
3. to list and describe possible injuries and typical chronic injuries in selected sports disciplines
Syllabus
  • Syllabus of lectures:
  • Fundamentals of genetics (genetic code, replication, transcription and translation of DNA, chromosomes). DNA diagnostics.
  • Pathophysiology of cell and cell interactions (apoptosis, necrosis, disease factors).
  • General manifestations of disease (fever, pain, inflammation).
  • Pathophysiology of stress (fatigue).
  • Acidobasic equilibrium disorders.
  • Disorders of carbohydrate metabolism (DM).
  • Disorders of lipid metabolism (hyperlipoproteinemia, hypolipoproteinemia). Pathophysiology of atherosclerosis.
  • Disorders of nucleotide metabolism (arthritis uratica, tumor breakdown syndrome). Disorders of hem and iron metabolism.
  • Consequences of hypokinesia. Some systemic manifestations of lack of physical activity.
  • Metabolic syndrome (definitions, signs, causes of onset).
  • Dysregulation of food intake and body weight (with negative energy balance, positive energy balance).
  • Acute damage in sports. Types of injuries. causes and mechanisms of injuries in sport due to the specificities of selected sports disciplines.
  • Chronic damage in sports.
  • Psychosomatics
  • Syllabus of exercises:
  • Influence of genetics on physical activity and obesity (human genome, sports genes, obesity genes, epigenetics, genetic tests etc.).
  • Influenced biological factors of preanalytical variability in biochemical sampling (race, sex, genetic factors, pregnancy, biorhythms, weight, lifestyle, physical load, diet, smoking).
  • Biochemical markers of inflammation (C-reactive protein, cytokines).
  • Biological indicators of fatigue. Questionnaire for fatigue manifestations (physiological + psychological) + its evaluation.
  • Subjective feelings, speaking test (practically).
  • Biochemical indicators of acid-base balance disorders (buffer systems, BE, PH, PO2, pCO2).
  • Selected stress tests and monitoring of physiological functions of carbohydrate metabolism disorders (oral glucose tolerance test - oGTT, monitoring of glycemia in motion activity - glucometers, biosensors).
  • Monitoring of physiological functions in lipid metabolism disorders (cholesterol, triacylglycerols, adiponectin, ghrelin, leptin). Ultrasound.
  • Metabolic syndrome - risk factors (anthropometric indicators, blood pressure measurements, biochemical indicators).
  • Anthropometric indicators (fat component, muscle component, bone density).
  • Risk analysis of injuries in relation to sports disciplines. Prevention principles.
  • Physical activity during pregnancy (recommendation) and postpartum (including diastase and umbilical hernia - practical demonstration).
  • Physiology and pathophysiology of running on runway and outdoors - practically.
  • Physiology and pathophysiology during treadmill and bicycle trekking. - practically
Literature
    recommended literature
  • OTOVÁ, Berta and František SOUKUP. Základy genetiky (Obsaž.) : Biologie člověka pro bakalářské studium na lékařských fakultách. info
  • STEJSKAL, Pavel. Metabolický syndrom – mezioborový problém. 1. vyd. Brno: Masarykova univerzita, 2014, 107 pp. ISBN 978-80-210-7539-9. info
  • SILBERNAGL, Stefan and Florian LANG. Atlas patofyziologie. Translated by Miloš Langmeier. 2., české vyd. Praha: Grada, 2012, x, 406. ISBN 9788024735559. info
  • KOHLÍKOVÁ, Eva. Patofyziologie ve schématech. 2., nezměn. vyd. Praha: Karolinum, 2012, 190 s. ISBN 9788024621715. info
  • MATĚJOVSKÁ KUBEŠOVÁ, Hana, Pavel WEBER, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ and Jana HRUBANOVÁ. Co je stárnutí z hlediska patofyziologie (Ageing from patophysiological point of view). Medical Tribune. 2010, VI, No 25, p. 5-25, 20 pp. ISSN 1214-8911. info
  • STRÁNSKÝ, Miroslav and Lydie PECHAN. Fyziologie a patofyziologie výživy. 1. vyd. České Budějovice: Jihočeská univerzita, 2010, 182 s. ISBN 9788073942410. info
  • SVAČINOVÁ, Hana. Metabolický syndrom (Metabolic syndrome). In Civilizace a nemoci. Praha: FUTURA Praha, 2009, 3 pp. 1. ISBN 978-80-86844-53-4. info
  • SVAČINA, Štěpán. Metabolický syndrom. 3. rozš. a přeprac. vyd. Praha: Triton, 2006, 282 s. ISBN 8072547828. info
  • KOHLÍKOVÁ, Eva. Cytopatologie, patobiochemie a patofyziologie : všeobecná část. 1. vyd. Praha: Karolinum, 2003, 259 s. ISBN 8024607174. info
Teaching methods
Lecture and practice. Exercises are both theoretical and practical, including laboratory testing. Teaching methods: presentation, discussion, demonstration of tests, practical measurements, homework (replenishment of worksheets).
Assessment methods
90% active participation in exercises. Student graduates. - 2 written tests. tests consist of   10 questions rated 20 points. To achieve successful mastery, it is necessary to achieve 14. - the working sheets drawn up and handed over. The whole subject is finished by an oral exam, evaluated by the A-F scale.
Language of instruction
Czech
Further Comments
Study Materials
The course is also listed under the following terms autumn 2020, autumn 2021, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2022, recent)
  • Permalink: https://is.muni.cz/course/fsps/autumn2022/bp4061