LF:STFA0722c Pharmacology I- p - Course Information

STFA0722c Pharmacology II - practice

Faculty of Medicine
Autumn 2009

Extent and Intensity

0/2/0. 4 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Alexandra Šulcová, CSc.

Prerequisites (in Czech)

STFA0621c Pharmacology I - p

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

Stomatology (programme LF, M-ST)

Course objectives

From the course on pharmacology students are expected to obtain: a) from lectures and seminars: a clarification of integration in the field of biomedical subjects such as chemistry, physiology, molecular biology, pathology and pathological physiology enabling them to understand why, what mechanism by, and what conditions on, drugs and their combinations may elicit therapeutic, adverse, and toxic effects. They will acquire an orientation in drug classes according to their main therapeutic indications with an attention paid to common drug-drug interactions, too. Information on drug development process, rules of preclinical and clinical drug testing will also be given. b) from practicals: a training in practical skills in "pharmacological thinking" in cases of need to make a choice of drug, dosing regimen, route and techniques of administration, and an elimination of adverse interactions with drugs simultaneously given.

Syllabus

SEMINARS Day 1 (Mon) - Introduction, organisatory remarks. Distribution of co-talks: Antibiotics and chemotherapeutics (6 topics). Sulfonamides, trimethoprim. Quinolones. Antituberculous drugs. Antiretroviral antivirotics. Antiherpetics. Histamine, H 1-3 receptors. Therapy of anaphylactic shock. Immunostimulation. Immunosuppression. 1 - ANALGESICS. Opioid and nonopioid analgesics. Pharmacotherapy of pain. Prescription and practical use of analgesic preparations. 2 - NON-STEROIDAL ANTIINFLAMMATORY DRUGS, DRUGS USED IN GOUT. Mechanisms of action and classification of antiinflammatory and antirheumatic drugs (NSAIDs and the 2nd-line agents). Drugs used in therapy of gout. Getting ready for the next lesson: NEW: Central neurotransmitters and sites of drug effects in CNS. Basic psychical functions. Revision: Authonomic nervous system (see spring semester). Day 2 (Tue) - 3 - PSYCHOTROPIC DRUGS. Classification and terminology of psychotropics. Pharmacology of anxiolytics and hypnosedatives. Mechanism of action of benzodiazepines. Work with PC - Microlabs, antidepressants. Prescription of hypnosedatives and psychostimulants. 4 - GENERAL ANAESTHETICS. Combined and balanced anaesthesia. Signs and stages of general anaesthesia. Inhaled and injected anaesthetics - classification and characteristics. Video-programme:General anaesthesia (cz). Getting ready for the next lesson: Revision: L 1 - 4 (analgesics and antiinflammatory drugs, classification and basic characteristics of psychotropic drugs, general anaesthetics). NEW: Pathophysiology of bronchial asthma. Co-talks: Role of histamine in the organism, receptors. Therapy of anaphylactic shock. Day 3 (Wed) - REVISING TEST I (Overhead-test with subsequent discussion) Analgesics and antiinflammatory drugs, classification and basic characteristics of psychotropic drugs, general anaesthetics. 5 - H1-ANTIHISTAMINES. Co-talk: Histamine; pathophysiological role, H1- H2 - H3 receptors. Classification and clinical use of H1-antihistamines. 6 - ANTIASTHMATICS. Pathophysiology of bronchial asthma, sites and mechanisms of action of antiasthma drugs. Co-talk: Therapy of anaphylactic shock. Prescription of antitussives, expectorants, antiasthmatics. Getting ready for the next lesson: Prescription of analgesics and hypnosedatives, respiratory tract. Day 4 (Thu) - PRESCRIPTION TEST: DRUGS ACTING IN CNS, RESPIRATORY TRACT (classified). 7 - LOCAL ANAESTHETICS. Mechanism of action, classification, practical use and prescription. 8 - SURFACE-ACTIVE DRUGS. Disinfectants, antiseptics, antifungal agents, other surface-active drugs. Prescription and use of selected surface-active preparations used in dermatology. Stomatological preparations. Getting ready for the next lesson: Revision: Authonomic nervous system. NEW: Diabetes mellitus. Peptic ulcer. Day 5 (Fri) - REVISING TEST II (Overhead-test with subsequent discussion). Autonomic nervous system (revision from the autumn semester). 9 - ANTIDIABETIC DRUGS. IDDM and NIDDM, principles of treatment. Insulin and its receptors. Insulin preparations, oral antidiabetics. 10 - DRUGS USED IN ULCER DISEASE, ANTIEMETICS. Classification, mechanisms of action and clinical use of drugs in therapy of peptic ulcer and vomiting. Getting ready for the next lesson: NEW: Adrenal corticosteroids. Anticancer agents. Co-talks: Immunosuppression, immunomodulation. Day 6 (Mon) - 11 - GLUCOCORTICOIDS Natural and synthetic adrenocorticosteroids, steroid receptors, mechanism of action, pharmacological use and side effects. 12 - PHARMACOLOGY OF ANTICANCER DRUGS. IMMUNOLOGICALLY ACTIVE SUBSTANCES. Classification, mechanisms of action, clinical use of anticancer agents. Co-talks: Immunosuppression, immunomodulation. Getting ready for the next lesson: Revision: Prescriptions of local anesthetics, selected surface-active drugs, ready-made preparations. NEW: Co-talks: Narrow-spectrum and beta-lactamase resistant penicillins. Intermediate and broad-spectrum penicillins. Cephalosporins. Aminoglycosides. Macrolides, lincosamines. Chloramphenicol and tetracyclines. Antituberculous drugs. Sulphonamides and trimethoprim. Quinolones. Antiretroviral antivirotics. Antiherpetics. Day 7 (Tue) - FINAL PRESCRIPTION TEST (classified): Local anesthetics, selected surface-active drugs, ready-made preparations Theme: 13 - ANTIMICROBIAL AGENTS Classification, mechanisms of action, combinations of antibiotics and chemotherapeutics. Co-talks. 14 - ANTIBACTERIAL CHEMOTHERAPEUTICS AND ANTIVIRAL AGENTS. Drugs acting in intestinal and urinary infections. Co-talks: Quinolones. Antiretroviral antivirotics. Antiherpetics. Antituberculous agents. Getting ready for the final test: Revision: L 9 - 14 (local anesthetics, glucocorticoids, anticancer drugs, therapy of diabetes and ulcer disease. Day 8 (Wed) - FINAL REVISING TEST (Overhead-test III, classified). Substitution tests. CREDITS.

Literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
HADAŠOVÁ, Eva, Jana NOVÁKOVÁ, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ, Alexandra ŠULCOVÁ and Olga STAROBOVÁ. Praktická cvičení z farmakologie (Practical lessons on pharmacology). 2. opravené a doplněné vyd. Brno: Vydavatelství MU Brno-Kraví Hora, 2003, 110 pp. Skripta. ISBN 80-210-2694-4. info
ZELENKOVÁ, Olga and Alexandra ŠULCOVÁ. Speciální stomatologická receptura pro praktická cvičení z farmakologie (Special stomatological prescriptions for practicals in pharmacology). 2. přepracované vydání. Brno: Masarykova univerzita v Brně, 2000, 30 pp. ISBN 80-210-2433-X. info
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993, 97 s. ISBN 80-210-0640-4. info
HYNIE, Sixtus. Farmakologie v kostce. 2., přeprac. vyd. V Praze: Triton, 2001, 520 s. ISBN 8072541811. info
LÜLLMANN, Heinz, Klaus MOHR and Lutz HEIN. Barevný atlas farmakologie. Translated by Maxmilián Wenke - Elfrída Mühlbachová. 3. vyd. Praha: Grada, 2007, xi, 372. ISBN 9788024716725. info

Assessment methods

During the studying the students have to prove active knowledge of pharmacology acquired. The students have to pass the final prescription test and multiple-choice test.

Language of instruction

Czech

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: in blocks.

The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007.

Enrolment Statistics (recent)
Permalink: https://is.muni.cz/course/med/autumn2009/STFA0722c

LF:STFA0722c Pharmacology I- p - Course Information

STFA0722c Pharmacology II - practice

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