LF:ZLFA0621p Pharmacology I - lect. - Course Information
ZLFA0621p Pharmacology I - lecture
Faculty of Medicinespring 2025
- Extent and Intensity
- 1/0/0. 1 credit(s). Type of Completion: z (credit).
In-person direct teaching - Teacher(s)
- doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Alena Máchalová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
PharmDr. Mária Hricková (seminar tutor)
PharmDr. Adéla Bártová (assistant)
Renata Bláblová (assistant)
Mgr. Marta Vyoralová (assistant)
doc. RNDr. Ladislava Bartošová, Ph.D. (alternate examiner)
Mgr. Barbora Říhová, Ph.D. (alternate examiner)
doc. MUDr. Regina Demlová, Ph.D. (lecturer) - Guaranteed by
- doc. PharmDr. Ondřej Zendulka, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine - Prerequisites
- ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
At the end of the course, the student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology, clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, the status of the organism (differences in paediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance. The student will know a basic pharmacological profile of selected drug groups. - Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Dentistry (programme LF, M-ZL) (2)
- Course objectives
- At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
- Learning outcomes
- At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
- Syllabus
Schedule of lectures
Spring semester 2024
- 23.2.2024
- 1. INTRODUCTION TO THE STUDY OF PHARMACOLOGY, DRUG'S LIFE CYCLE
- Lecture content: Definitions and basic pharmacologic terminology, pharmacological subdisciplines. Classification of drugs and drug's names.Types of pharmacotherapy, rational pharmacotherapy. Legislative related to the drugs use. Drug safety, types of doses. Drug's life cycle.
- 1.3.2024
- 2. BASIC OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Lecture content: Obecné zákonitosti pohybu léčiva v organismu. Absorpce, distribuce, biotransformace, vylučování. Základní farmakokinetické parametry. Specifické a nespecifické mechanismy účinků léčiv. Receptorová teorie.
- 8.3.2024
- 3. SAFETY OF DRUGS, FACTORS INFLUENCING DRUG'S EFFECT
- Lecture content: Classification and characteristic of drug's adverse effects. Pharmacovigilance and drugs' safety information databases. Classification and overview of factors influencing drug's effect. Basics of pharmacogenetics, Classification of drug interactions. Pharmacotherapy in children, pregnancy, breast-feeding and in elders.
- 15.3.2024
- 4. ANTIDIABETICS, INSULINS
- Lecture content: Inzulins and antidiabetics – classification, therapeutic use and basic pharmacological profile.
- 22.3.2024
- 5. PHARMACOLOGICALLY USED HORMONES
- Lecture content: Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens – basic pharmacological profile. Hormonal contraceptives. Drugs used in thyroid gland dysfunction. Drugs influencing bone metabolism. Overview of glucocrticoids and their therapeutic use.
- 29.3.2024
- 6. PUBLIC HOLIDAY/INTRODUCTION TO THE PHARMACOLOGY OF ANS
- Lecture content: Introduction to the pharmacology of sympathetic and parasympathetic nervous system - neurotransmission, receptors. Overview of sympathotropic and cholinotropic drugs. Record of lecture will be available in the IS.
- 5.4.2024
- 7. PHARMACOLOGY OF GIT AND HISTAMINE
- Lecture content: Drugs influencing GIT – laxatives, antidiarrhoics, antiemetics, antiulcer agents. Classification and overview of H1-antihistamines.
- 12.4.2024
- 8. INTRODUCTION OF BIOLOGICAL THERAPY
- Lecture content: Principles of biological therapy, examples of drugs and their use, pharmacokinetics of monoclonal antibodies and their specific adverse effects.
- Literature
- recommended literature
- RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN, Emma S. J. ROBINSON and James FULLERTON. Rang & Dale's pharmacology / James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEvan, Emma Robinson, James Fullerton. Tenth edition. London: Elsevier, 2024, xvii, 850. ISBN 9780323873963. info
- http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
- Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy
- NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010, 96 pp. ISSN 1801-6103. URL info
- Základy speciální receptury léčivých přípravků, Juřica a kol., 2014, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
- Soubor kazuistik z farmakologie, Zendulka a kol., 2016 http://elportal.cz/publikace/kazuistiky-farmakologie
- not specified
- ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
- MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
- Teaching methods
- Teaching is in the form of lectures, where students can raise questions on the topic directly to the lecturer. A video recording is made of the lecture, which is available to students for self-study. In addition, students have the possibility to raise questions to the lecturer of each topic using the discussion forum in IS.
- Assessment methods
- Students progress to the follow-up course in the following semester without the obligation to test their knowledge in this semester.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15. - Teacher's information
- Information for students studying in Czech:
In the spring semester, the course is completed with credit. After receiving credit, students move on to continuing education in the next semester without having to test their knowledge in that semester. Further assessment conditions in the follow-up course are published for students under the course code ZLFA0621c.
The lecture recording and discussion thread for each lecture is embedded within the interactive syllabus in IS.
- Enrolment Statistics (spring 2025, recent)
- Permalink: https://is.muni.cz/course/med/spring2025/ZLFA0621p