aBFBC011p Biochemistry - lecture

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
RNDr. Hana Paulová, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Biochemistry for bachelors follows secondary school chemistry and biochemistry broadens the subject considerably to the level required for the study of successive subjects. The aim of the subject is to provide a comprehensive view of the basic metabolic processes in the human body related to the functioning of the human organism. Course will provide information on the production and use of energy in the human body, the structure and synthesis of the main molecules, the main regulatory mechanisms that maintain homeostasis. Students will obtain knowledge about the biochemical nature of the most important disorders of metabolism and bases of their clinico-biochemical examination, taking into account their specialization.
Learning outcomes
After the completion of the course student will:
- understand physico-chemical processes important for biological systems,
- be able to explain basic principles of nutrient metabolism, discusses the principles of regulation.
- understand how energy is generated, used, and stored by the various organs of the body.
- describe the biochemical processes typical for main organs and tissues in the body (heart, liver, kidney, muscle, nerve tissue).
- be able to explain the basic principles of homeostasis.
- be familiar with the effects of major hormones and the principle of their action through receptors.
- characterize the composition and function of the main body fluids. Understands the processes of hemocoagulation.
Syllabus
  • Basic terms. Solutions, concentrations. Electrolytes.osmotic pressure.
  • Protolytic reactions, acids, bases, pH, Hydrolysis of salts, buffers.
  • macrobiogenic and microbiogenic elements.Biochemically important inorganic compounds.
  • Organic compounds, hydrocarbonds and their deriatives.Alcohols, phenols, ethers. Carbonyl compounds. keton bodies.Carboxylic acids and their deivatives.Amines, heterocycles and their biochemically important derivatives.tnsides.
  • The chemistry of saccharides. Important monosaccharides and their derivatives.
  • Aminoacids, peptides, proteins.
  • Enzymes, structure, mechanism of action. Enzyme classification and nomenclature.Enzymes important in clinical biochemistry.
  • Lipids, phospholipids, glycolipids. Eicosanoids, steroids overview.Cholesterol.
  • Nucleosides and nucleotides, types of nucleic acids.replication, transcription.
  • Hemoproteins. Hem. Bile pigments.
  • General principles of metabolism. High-energy compounds. Citric acid cycle. Respiration chain, aerobic phosphorylation.
  • Saccharide metabolism, glycolysis, gluconeogenesis, synthesis of glycogen.
  • Metabolism of proteins and aminoacids. Proteins in food and their digestion. Intracellular degradation of proteins. Common features of amino acid degradation.Synthesis of urea.
  • Digestion and resorption of lipids. Fatty acid metabolism, ketogenesis. Cholesterol.
  • Characteristic features of metabolism at various conditions. metabolic aspects of diabetes.
  • Hormones, mechanism of their action. Neuron, neurotransmitters.
  • Biochemistry of liver.
  • Biochemistry of blood. Proteins in blood. Blood coagulation.
  • Water and ions in organism.
  • Biochemistry of kidneys.
  • Muscle proteins, molecular principles of contraction and relaxation.Smooth muscle. Biochemical markers of infarction.
  • Metabolism of xenobiotics.
  • Structure and metabolism of connective tissue.
  • Biochemistry of vision, rhodopsine cycle. Metabolism of the cornea and the lens.
Literature
    required literature
  • FRY, Mitchell. Essential Biochemistry for Medicine. 1st Ed. Wiley-Blackwell, 2010, 308 pp. ISBN 978-0-470-74328-7. info
Teaching methods
Teaching form lectures, 2 hours per week.
Assessment methods
The course is concluded by the oral examination. Examination is composed of two parts. The first part is a simple test on a computer, the second part is oral. The test includes 25 basal questions from the whole content of the recommended book, including chapters 1-4, calculations of concentration, pH and osmolarity. Only those students who gain 13 correct answers at a minimum will be permitted to sit for the oral examination. The model test is available on IS MUNI in the ROPOT section. List of questions and other instructions you will find in the section Study materials of the course.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020.
  • Enrolment Statistics (recent)
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