VLIM051 Immunology

Faculty of Medicine
Autumn 2001
Extent and Intensity
2/1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Jindřich Lokaj, CSc. (lecturer)
prof. MUDr. Jiří Litzman, CSc. (seminar tutor)
prof. MUDr. Jindřich Lokaj, CSc. (seminar tutor)
MUDr. Ivo Nentwich, Ph.D. (seminar tutor)
prof. MUDr. Vojtěch Thon, Ph.D. (seminar tutor)
Guaranteed by
prof. MUDr. Jindřich Lokaj, CSc.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Jindřich Lokaj, CSc.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus
  • Immunology in medicine.
  • Anatomy and cellular elements of the immune system.
  • Immune mechanisms. Innate and acquired immunity.
  • Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation.
  • B lymphocytes and immunoglobulins.
  • Genetic basis of immunoglobulin heterogeneity.
  • Biological properties of antibodies.
  • Monoclonal antibodies as diagnostic and therapeutic tools.
  • T-lymphocytes, their development and effector functions.
  • Polarisation of T-lymphocytes (T1, T2). Cytotoxicity. Cytokines.
  • Major histocompatibility complex: structure, function.
  • Activation of T and B cells by antigen.
  • Interactions between antigen-presenting cells and T- and B-lymphocytes.
  • Regulation of the immune reaction.
  • Mucosal immunity.
  • Immunity against infection agents. Microbial antigens.
  • Active and passive immunisation.
  • Primary and secondary immunodeficiency disorders.
  • HIV disease.
  • Immunoglobulin therapy. Immunostimulation.
  • Autoimmunity and disease. Immunological tolerance.
  • Autoantibodies and their laboratory detection.
  • Hypersensitivity reactions - anaphylactic, cytotoxic, immune complex, T-cell-mediated.
  • Clinical allergology. Allergic skin and exposition tests.
  • Ontogenesis of the immune system. Immunity in pregnancy. Reproduction immunology.
  • Immunologic disorders in infants and children. Immunity in elderly.
  • Tumor immunology. Tumor antigens. Immune response to tumors. Immunodiagnosis of tumors. Immune-related malignancies.
  • Transfusion immunology. ABO system. Rh system. Transfusion reactions.
  • Immunology of organ and bone marrow transplantation. Graft vs. host reaction.
Literature
  • LITZMAN, Jiří, Martin PETŘEK and Vojtěch THON. Vyšetřovací metody v klinické imunologii (Investigation methods in clinical immunology). 1st ed. Brno: Masarykova universita, 1998, 45 pp. ISBN 80-210-1807-0. info
  • HOŘEJŠÍ, Václav and Jiřina BARTŮŇKOVÁ. Základy imunologie. Vyd. 1. V Praze: Triton, 1998, 219 s. ISBN 80-85875-73-X. info
  • FUČÍKOVÁ, Terezie. Základy klinické imunologie :imunodeficity - autoimunita - alergie. [1. vyd.]. Praha: RDI PRESS, 1994, 148 s. ISBN 80-900674-3-3. info
  • Immunology :a short course. Edited by Eli Benjamini - Sidney Leskowitz. 2nd ed. New York: Wiley-Liss, 1991, xxvi, 459. ISBN 0-471-56751-5. info
Assessment methods (in Czech)
Zápočet po absolvování povinné výuky.
Závěrečná rigorózní ústní zkouška
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2000, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005.
  • Enrolment Statistics (Autumn 2001, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2001/VLIM051