LF:BLIM0411p Clinical imunology-lecture - Course Information

BLIM0411p Clinical imunology-lecture

Extent and Intensity

4/0/0. 3 credit(s). Type of Completion: zk (examination).

Teacher(s)

prof. MUDr. Jiří Litzman, CSc. (lecturer)
Miroslava Bučková (assistant)

Guaranteed by

prof. MUDr. Jiří Litzman, CSc.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Jiří Litzman, CSc.

Prerequisites (in Czech)

BLFY0222p Physiology II-lec.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• Laboratory Assistant (programme LF, B-SZ)

Course objectives

The course will give a basic information about structural and functional characteristics of the immune system, about physiology and pathology of immunity, immunological treatment and prophylaxis and about possibilities of laboratory immunological approaches to asses the immune status of a patient. After finishing the course the students will understand the mechanisms of the immune response in physiology, and the knowledge will enable them to understand the immune system disturbances leading to immunopathological diseases, such as possibilities of immunological laboratory diagnostic.

Syllabus

• Immunology in medicine. Medical subject allergology and clinical immunology. Physiology and pathology of the immune system. Immunological concept of “own”, “foreign”, “dangerous”. Anatomy and cellular elements of the immune system. Immune mechanisms. Innate and acquired immunity. Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation. B lymphocytes and immunoglobulins. Genetic basis of immunoglobulin heterogeneity. Biological properties of antibodies. Monoclonal antibodies as diagnostic and therapeutic tools. T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (T1, T2, Th17). Cytotoxicity. Cytokines. Major histocompatibility complex: structure, function. Activation of T and B cells by antigen. Interactions between antigen-presenting cells and T- and B-lymphocytes. Regulation of the immune reaction. Mucosal immunity. Immunity against infectious agents. Microbial antigens. Active and passive immunisation. Imunology of pregnancy. Age factor and immune system in humans Primary and secondary immunodeficiency disorders. HIV disease. Active and passive immunisation. Immunoglobulin therapy. Immunostimulation. Autoimmunity and disease. Immunological tolerance. Autoantibodies and their laboratory detection. Clinically significant organ specific and organ non-specific autoantibodies. Hypersensitivity reactions - anaphylactic, cytotoxic, immune complex, T-cell-mediated. Clinical allergology. Allergic skin and exposition tests. Prevention and treatment of allergic diseases. Transfusion immunology. ABO system. Rh system. Transfusion reactions. Immunology of organ and bone marrow transplantation. Graft vs. host reaction Tumor immunology. Tumor antigens. Immune response to tumors. Immunodiagnosis of tumors. Immune-related malignancies. Paraproteins, detection, clinical significancy. Clinical significance of paraproteinemia.

Literature

• HOŘEJŠÍ, Václav and Jiřina BARTŮŇKOVÁ. Základy imunologie. 3. vyd. Praha: Triton, 2005, 279 s. ISBN 8072546864. info
• ABBAS, Abul K. and Andrew H. LICHTMAN. Basic immunology : functions and disorders of the immune system. Illustrated by David L. Baker - Alexandra Baker. 2nd ed. Philadelphia: Saunders, 2004, ix, 322. ISBN 072160241X. info

Assessment methods

The subject is given in a form of lectures and is finihed by an oral exam.

Language of instruction

Czech

• Enrolment Statistics (Autumn 2009, recent)
  
• Permalink: https://is.muni.cz/course/med/autumn2009/BLIM0411p