BKBC011p Biochemistry - lecture

Faculty of Medicine
Autumn 2013
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
Ing. Jana Simonová, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Thu 26. 9. to Fri 20. 12. Thu 16:00–17:50 B11/114; and Thu 19. 9. 17:00–18:50 B22/116 aula
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The subject follows secondary school chemistry and broadens the content considerably to the level required for the study of successive subjects. After the completition of the subject student will understand physico-chemical processes important for biological systems, will know the structures and names pf biochemically important inorganic and organic compounds and explain their significance. He/she decribes the structure and properties of saccharides, lipids, steroids, amino acids, proteins, nucleotides and nucleic acids. He/she will be able to explain the metabolism of nutrients and principles of its regulation.He/she understands how energy is generated, used, and stored by the various organs of the body. He/she will describe the biochemical proceses typical for main organs and tissues in the body.
Syllabus
  • Basic terms. Solutions, concentrations. Electrolytes.osmotic pressure.
  • Protolytic reactions, acids, bases, pH, Hydrolysis of salts, buffers.
  • macrobiogenic and microbiogenic elements.Biochemically important inorganic compounds.
  • Organic compounds, hydrocarbonds and their deriatives.Alcohols, phenols, ethers. Carbonyl compounds. keton bodies.Carboxylic acids and their deivatives.Amines, heterocycles and their biochemically important derivatives.tnsides.
  • The chemistry of saccharides. Important monosaccharides and their derivatives.
  • Aminoacids, peptides, proteins.
  • Enzymes, structure, mechanism of action. Enzyme classification and nomenclature.Enzymes important in clinical biochemistry.
  • Lipids, phospholipids, glycolipids. Eicosanoids, steroids overview.Cholesterol.
  • Nucleosides and nucleotides, types of nucleic acids.replication, transcription.
  • Hemoproteins. Hem. Bile pigments.
  • General principles of metabolism. High-energy compounds. Citric acid cycle. Respiration chain, aerobic phosphorylation.
  • Saccharide metabolism, glycolysis, gluconeogenesis, synthesis of glycogen.
  • Metabolism of proteins and aminoacids. Proteins in food and their digestion. Intracellular degradation of proteins. Common features of amino acid degradation.Synthesis of urea.
  • Digestion and resorption of lipids. Fatty acid metabolism, ketogenesis. Cholesterol.
  • Characteristic features of metabolism at various conditions. metabolic aspects of diabetes.
  • Hormones, mechanism of their action. Neuron, neurotransmitters.
  • Biochemistry of liver.
  • Biochemistry of blood. Proteins in blood. Blood coagulation.
  • Water and ions in organism.
  • Biochemistry of kidneys.
  • Muscle proteins, molecular principles of contraction and relaxation.Smooth muscle. Biochemical markers of infarction.
  • Metabolism of xenobiotics.
  • Structure and metabolism of connective tissue.
  • Biochemistry of vision, rhodopsine cycle. Metabolism of the cornea and the lens.
Literature
Teaching methods
Teaching form are lectures, 2 hours per week.
Assessment methods
The course is concluded by the oral examination.Examination is composed of two parts. First part is a simple test on a computer, the second part is oral.The test includes 25 basal questions from the whole content of the recommended book, including chapters 1-4, calculations of concentration, pH and osmolarity. Only those students who gain 13 correct answers at a minimum will be permitted to sit for the oral examination.The model test is available on IS MUNI in the ROPOT section. List of questions and other instructions you will find in the section Study materials of the course.
Language of instruction
Czech
Further Comments
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (Autumn 2013, recent)
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