aVLKG7X1p Clinical Genetics - lecture

Faculty of Medicine
Autumn 2017
Extent and Intensity
1/0/0. 1 credit(s). Type of Completion: k (colloquium).
Teacher(s)
MUDr. Renata Gaillyová, Ph.D. (lecturer)
MUDr. Šárka Prášilová (seminar tutor)
MUDr. Jana Šoukalová (seminar tutor)
RNDr. Iveta Valášková, Ph.D. (seminar tutor)
Mgr. Marta Navaříková (seminar tutor)
Mgr. Hana Filková (seminar tutor)
Mgr. Silvie Dudová (seminar tutor)
Mgr. Kateřina Kašíková, Ph.D. (seminar tutor)
Mgr. Martina Vráblíková (assistant)
Mgr. Kateřina Vopěnková, Ph.D. (assistant)
prof. MUDr. Michael Doubek, Ph.D. (lecturer)
doc. RNDr. Lenka Fajkusová, CSc. (lecturer)
doc. MUDr. Lenka Foretová, Ph.D. (lecturer)
prof. MVDr. RNDr. Petr Hořín, CSc. (lecturer)
MUDr. Věra Hořínová (lecturer)
doc. MUDr. Hana Ošlejšková, Ph.D. (lecturer)
prof. MUDr. Marek Svoboda, Ph.D. (lecturer)
doc. Mgr. Martin Trbušek, Dr. (lecturer)
Guaranteed by
prof. MUDr. Michael Doubek, Ph.D.
Department of Internal Medicine, Hematology and Oncology – Joint workplaces with the University Hospital Brno - workplaces of the Bohunice and Mater. Hospital – Faculty of Medicine
Supplier department: Department of Internal Medicine, Hematology and Oncology – Joint workplaces with the University Hospital Brno - workplaces of the Bohunice and Mater. Hospital – Faculty of Medicine
Prerequisites (in Czech)
aVLLM0522p Medical Microbiology II - lect && aVLIM051p Immunology - lecture && aVLLP0633c Clinical Introduction III - p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of clinical genetics and its interdisciplinary character. Recent and modern concepts of genetic disorders, prevention of genetic diseases and congenital defects and relevant modern diagnostic methods are presented to students. As an extension of these topics, ethical, juridical and psychosocial issues are discussed. The subject matter presented in this course will help to better understand other medical subjects including internal medicine, neurology, surgery etc.
Learning outcomes
Student will be able to:
- to examine the patient with suspected genetic disease
- build a lineage
- to indicate the tests that will lead to the diagnosis of genetic diseases
- Have a basic overview of cytogenetic and molecular biological methods
- have a basic overview of the types of inheritance and the most important inherited diseases
Syllabus
  • Principles of clinical genetics
  • - standard karyotype and its abnormalities
  • - indication criteria for prenatal and postnatal karyotype examination
  • - prenatal cytogenetic methods
  • - prenatal screening examinations
  • – chromosomal aberrations
  • – chromosome instability
  • – principles of DNA diagnostics
  • - prenatal diagnostics using methods of molecular genetics
  • – gene therapy and mapping of the human genome – principles of oncocytogenetics
  • – genetic counseling - case reports.
Literature
  • Základem studia je látka přednášená na přednáškách a probíraná na seminářích a stážích z klinické genetiky a materiály v IS.
  • D.J.Pritchard, B.R.Korf: Základy lékařské genetiky, Galén 2007
  • Nussbaum, Mc Illnes, :Thompson & Thompson: Klinická genetika, 2004
  • SRŠEŇ, Štefan and Klára SRŠŇOVÁ. Základy klinickej genetiky. 2. preprac. a rozš. vyd. Martin: Vydavateľstvo Osveta, 1995, 259 s. ISBN 8021704772. info
  • KUČEROVÁ, Maria. Vrozené a získané poruchy lidských chromosomů. 2., dopl. vyd. Praha: Avicenum, 1988, 177 s. URL info
  • HYÁNEK, Josef. Klinické a biochemické aspekty vrozených metabolických poruch. 1. vyd. Praha: Avicenum, 1980, 280 s. info
  • MICHALOVÁ, Kyra. Úvod do lidské cytogenetiky. Vyd. 1. V Brně: Institut pro další vzdělávání pracovníků ve zdravotnictví v Brně, 1999, 172 s. ISBN 8070132817. info
  • Vojtíšková M.: Klinická molekulární genetika, IDVPZ Brno, 1999
  • ŠMARDA, Jan. Člověk v proudu dědičnosti (Geny v lidském zdraví a nemoci) (Man in the stream of heredity). Praha: Grada-Avicenum, 1999, 136 pp. ISBN 80-7169-768-0. info
  • Pokroky v lékařské genetice. Edited by Jan Kapras. 1. vyd. Praha: Avicenum, 1992, 141 s. ISBN 80-85047-10-1. info
  • ŽIŽKA, Jan. Diagnostika syndromů a malformací. 1. vyd. Praha: Galén, 1994, 414 s. ISBN 80-85824-04-3. info
  • Practical genetic counselling. Edited by Peter S. Harper. 4th ed. Oxford: Butterworth-Heinemann, 1993, 348 s. ISBN 0-7506-0928-1. info
  • Atlas klinických syndromů :pro kliniku a praxi. Edited by H.-R Wiedemann - J. Kunze - F.-R Grosse, Translated by Miloslav Navrá. 1. vyd. Martin: Osveta, 1996, xxvii, 684. ISBN 80-217-0517-5. info
  • George H. Sack, Jr. : Medical Genetics
Teaching methods
one-hour lecture per week
Assessment methods
written colloquium, for giving of course-unit credit is necessary full attendance in the lessons
Language of instruction
English
Further Comments
The course is taught: every week.
The course is also listed under the following terms Spring 2018, autumn 2018, spring 2019, autumn 2019, spring 2020, autumn 2020, spring 2021, autumn 2021, spring 2022, autumn 2022, spring 2023, autumn 2023, spring 2024, autumn 2024, spring 2025.
  • Enrolment Statistics (Autumn 2017, recent)
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