VLFA07212c Pharmacology I - practice

Faculty of Medicine
autumn 2021
Extent and Intensity
0/3/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
PharmDr. Adéla Bártová (seminar tutor)
MUDr. Anh Tu Bui (seminar tutor)
MVDr. Eva Dražanová, Ph.D. (seminar tutor)
PharmDr. Tomáš Hammer (seminar tutor)
PharmDr. Mária Hricková (seminar tutor)
PharmDr. Eva Klásková (seminar tutor)
PharmDr. Katarína Kostolanská (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
MUDr. Filip Šiška (assistant)
Mgr. Marta Vyoralová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Barbora Říhová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
VLFA07212c/01: Wed 22. 9. 13:00–15:30 A19/231, Wed 29. 9. 13:00–15:30 A19/231, Wed 6. 10. 13:00–15:30 A19/231, Wed 13. 10. 13:00–15:30 A19/231, Wed 20. 10. 13:00–15:30 A19/231, Wed 27. 10. 13:00–15:30 A19/231, Wed 3. 11. 13:00–15:30 A19/231, Wed 10. 11. 13:00–15:30 A19/231, Wed 24. 11. 13:00–15:30 A19/231, Wed 1. 12. 13:00–15:30 A19/231, Wed 8. 12. 13:00–15:30 A19/231, Wed 15. 12. 13:00–15:30 A19/231, Wed 5. 1. 13:00–15:30 A19/231, Wed 12. 1. 13:00–15:30 A19/231, L. Bartošová
VLFA07212c/02: Wed 22. 9. 13:00–15:30 A19/326, Wed 29. 9. 13:00–15:30 A19/326, Wed 6. 10. 13:00–15:30 A19/326, Wed 13. 10. 13:00–15:30 A19/326, Wed 20. 10. 13:00–15:30 A19/326, Wed 27. 10. 13:00–15:30 A19/326, Wed 3. 11. 13:00–15:30 A19/326, Wed 10. 11. 13:00–15:30 A19/326, Wed 24. 11. 13:00–15:30 A19/326, Wed 1. 12. 13:00–15:30 A19/326, Wed 8. 12. 13:00–15:30 A19/326, Wed 15. 12. 13:00–15:30 A19/326, Wed 5. 1. 13:00–15:30 A19/326, Wed 12. 1. 13:00–15:30 A19/326, P. Amchová, B. Říhová
VLFA07212c/03: Tue 21. 9. 13:00–15:30 A19/326, Tue 5. 10. 13:00–15:30 A19/326, Tue 12. 10. 13:00–15:30 A19/326, Tue 19. 10. 13:00–15:30 A19/326, Tue 26. 10. 13:00–15:30 A19/326, Tue 2. 11. 13:00–15:30 A19/326, Tue 9. 11. 13:00–15:30 A19/326, Tue 16. 11. 13:00–15:30 A19/326, Tue 23. 11. 13:00–15:30 A19/326, Tue 30. 11. 13:00–15:30 A19/326, Tue 7. 12. 13:00–15:30 A19/326, Tue 14. 12. 13:00–15:30 A19/326, Tue 4. 1. 13:00–15:30 A19/326, Tue 11. 1. 13:00–15:30 A19/326, L. Bartošová, B. Říhová
VLFA07212c/04: Tue 21. 9. 13:00–15:30 A19/231, Tue 5. 10. 13:00–15:30 A19/231, Tue 12. 10. 13:00–15:30 A19/231, Tue 19. 10. 13:00–15:30 A19/231, Tue 26. 10. 13:00–15:30 A19/231, Tue 2. 11. 13:00–15:30 A19/231, Tue 9. 11. 13:00–15:30 A19/231, Tue 16. 11. 13:00–15:30 A19/231, Tue 23. 11. 13:00–15:30 A19/231, Tue 30. 11. 13:00–15:30 A19/231, Tue 7. 12. 13:00–15:30 A19/231, Tue 14. 12. 13:00–15:30 A19/231, Tue 4. 1. 13:00–15:30 A19/231, Tue 11. 1. 13:00–15:30 A19/231, P. Amchová
VLFA07212c/05: Mon 20. 9. 13:00–15:30 A19/231, Mon 27. 9. 13:00–15:30 A19/231, Mon 4. 10. 13:00–15:30 A19/231, Mon 11. 10. 13:00–15:30 A19/231, Mon 18. 10. 13:00–15:30 A19/231, Mon 25. 10. 13:00–15:30 A19/231, Mon 1. 11. 13:00–15:30 A19/231, Mon 8. 11. 13:00–15:30 A19/231, Mon 15. 11. 13:00–15:30 A19/231, Mon 22. 11. 13:00–15:30 A19/231, Mon 29. 11. 13:00–15:30 A19/231, Mon 6. 12. 13:00–15:30 A19/231, Mon 13. 12. 13:00–15:30 A19/231, Mon 3. 1. 13:00–15:30 A19/231, Mon 10. 1. 13:00–15:30 A19/231, L. Bartošová
VLFA07212c/06: Thu 23. 9. 16:00–18:30 A19/326, Thu 30. 9. 16:00–18:30 A19/326, Thu 7. 10. 16:00–18:30 A19/326, Thu 14. 10. 16:00–18:30 A19/326, Thu 21. 10. 16:00–18:30 A19/326, Thu 4. 11. 16:00–18:30 A19/326, Thu 11. 11. 16:00–18:30 A19/326, Thu 18. 11. 16:00–18:30 A19/326, Thu 25. 11. 16:00–18:30 A19/326, Thu 2. 12. 16:00–18:30 A19/326, Thu 9. 12. 16:00–18:30 A19/326, Thu 16. 12. 16:00–18:30 A19/326, Thu 6. 1. 16:00–18:30 A19/326, Thu 13. 1. 16:00–18:30 A19/326, A. Máchalová, J. Pistovčáková
VLFA07212c/07: Tue 21. 9. 16:00–18:30 A19/326, Tue 5. 10. 16:00–18:30 A19/326, Tue 12. 10. 16:00–18:30 A19/326, Tue 19. 10. 16:00–18:30 A19/326, Tue 26. 10. 16:00–18:30 A19/326, Tue 2. 11. 16:00–18:30 A19/326, Tue 9. 11. 16:00–18:30 A19/326, Tue 16. 11. 16:00–18:30 A19/326, Tue 23. 11. 16:00–18:30 A19/326, Tue 30. 11. 16:00–18:30 A19/326, Tue 7. 12. 16:00–18:30 A19/326, Tue 14. 12. 16:00–18:30 A19/326, Tue 4. 1. 16:00–18:30 A19/326, Tue 11. 1. 16:00–18:30 A19/326, A. Bui, K. Kostolanská
VLFA07212c/08: Fri 24. 9. 13:00–15:30 A19/231, Fri 1. 10. 13:00–15:30 A19/231, Fri 8. 10. 13:00–15:30 A19/231, Fri 15. 10. 13:00–15:30 A19/231, Fri 22. 10. 13:00–15:30 A19/231, Fri 29. 10. 13:00–15:30 A19/231, Fri 5. 11. 13:00–15:30 A19/231, Fri 12. 11. 13:00–15:30 A19/231, Fri 19. 11. 13:00–15:30 A19/231, Fri 26. 11. 13:00–15:30 A19/231, Fri 3. 12. 13:00–15:30 A19/231, Fri 10. 12. 13:00–15:30 A19/231, Fri 17. 12. 13:00–15:30 A19/231, Fri 7. 1. 13:00–15:30 A19/231, Fri 14. 1. 13:00–15:30 A19/231, J. Kubátová, A. Máchalová
VLFA07212c/09: Mon 20. 9. 13:00–15:30 A19/326, Mon 27. 9. 13:00–15:30 A19/326, Mon 4. 10. 13:00–15:30 A19/326, Mon 11. 10. 13:00–15:30 A19/326, Mon 18. 10. 13:00–15:30 A19/326, Mon 25. 10. 13:00–15:30 A19/326, Mon 1. 11. 13:00–15:30 A19/326, Mon 8. 11. 13:00–15:30 A19/326, Mon 15. 11. 13:00–15:30 A19/326, Mon 22. 11. 13:00–15:30 A19/326, Mon 29. 11. 13:00–15:30 A19/326, Mon 6. 12. 13:00–15:30 A19/326, Mon 13. 12. 13:00–15:30 A19/326, Mon 3. 1. 13:00–15:30 A19/326, Mon 10. 1. 13:00–15:30 A19/326, K. Kostolanská, L. Landa
VLFA07212c/10: Thu 23. 9. 13:00–15:30 A19/231, Thu 30. 9. 13:00–15:30 A19/231, Thu 7. 10. 13:00–15:30 A19/231, Thu 14. 10. 13:00–15:30 A19/231, Thu 21. 10. 13:00–15:30 A19/231, Thu 4. 11. 13:00–15:30 A19/231, Thu 11. 11. 13:00–15:30 A19/231, Thu 18. 11. 13:00–15:30 A19/231, Thu 25. 11. 13:00–15:30 A19/231, Thu 2. 12. 13:00–15:30 A19/231, Thu 9. 12. 13:00–15:30 A19/231, Thu 16. 12. 13:00–15:30 A19/231, Thu 6. 1. 13:00–15:30 A19/231, Thu 13. 1. 13:00–15:30 A19/231, J. Pistovčáková
VLFA07212c/11: Tue 21. 9. 16:00–18:30 A19/231, Tue 5. 10. 16:00–18:30 A19/231, Tue 12. 10. 16:00–18:30 A19/231, Tue 19. 10. 16:00–18:30 A19/231, Tue 26. 10. 16:00–18:30 A19/231, Tue 2. 11. 16:00–18:30 A19/231, Tue 9. 11. 16:00–18:30 A19/231, Tue 16. 11. 16:00–18:30 A19/231, Tue 23. 11. 16:00–18:30 A19/231, Tue 30. 11. 16:00–18:30 A19/231, Tue 7. 12. 16:00–18:30 A19/231, Tue 14. 12. 16:00–18:30 A19/231, Tue 4. 1. 16:00–18:30 A19/231, Tue 11. 1. 16:00–18:30 A19/231, T. Hammer, J. Nováková
VLFA07212c/12: Thu 23. 9. 13:00–15:30 A19/326, Thu 30. 9. 13:00–15:30 A19/326, Thu 7. 10. 13:00–15:30 A19/326, Thu 14. 10. 13:00–15:30 A19/326, Thu 21. 10. 13:00–15:30 A19/326, Thu 4. 11. 13:00–15:30 A19/326, Thu 11. 11. 13:00–15:30 A19/326, Thu 18. 11. 13:00–15:30 A19/326, Thu 25. 11. 13:00–15:30 A19/326, Thu 2. 12. 13:00–15:30 A19/326, Thu 9. 12. 13:00–15:30 A19/326, Thu 16. 12. 13:00–15:30 A19/326, Thu 6. 1. 13:00–15:30 A19/326, Thu 13. 1. 13:00–15:30 A19/326, O. Zendulka
VLFA07212c/13: Fri 24. 9. 13:00–15:30 A19/326, Fri 1. 10. 13:00–15:30 A19/326, Fri 8. 10. 13:00–15:30 A19/326, Fri 15. 10. 13:00–15:30 A19/326, Fri 22. 10. 13:00–15:30 A19/326, Fri 29. 10. 13:00–15:30 A19/326, Fri 5. 11. 13:00–15:30 A19/326, Fri 12. 11. 13:00–15:30 A19/326, Fri 19. 11. 13:00–15:30 A19/326, Fri 26. 11. 13:00–15:30 A19/326, Fri 3. 12. 13:00–15:30 A19/326, Fri 10. 12. 13:00–15:30 A19/326, Fri 17. 12. 13:00–15:30 A19/326, Fri 7. 1. 13:00–15:30 A19/326, Fri 14. 1. 13:00–15:30 A19/326, M. Hricková, E. Klásková, K. Kostolanská
Prerequisites (in Czech)
VLPF0622p Pathophysiology II - lecture && VLPA0622c Pathology - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Learning outcomes
At the end of the course the student knows:
single pharmacoterapeutical drug clases
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Syllabus

  • VLFA07212c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2021

  • Topic 1: INFORMATION ON DRUGS
  • Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (SUKL, EMA, AISLP), ATC classification.
  • Topic 2: ROUTES OF DRUG ADMINISTRATION, DRUG DOSAGE FORMS, PRESCRIPTION OF READY-MADE MEDICINAL PRODUCTS
  • Brief characteristics of the individual drug dosage forms. Clinical significance of the way of drug administration. prescription of RMP.
  • Topic 3: PRESCRIPTION OF MEDICINAL PRODUCTS
  • Prescription of the individually prepared medicinal products.
  • Topic 4: PHARMACOKINETICS I
  • Pharmacokinetic processes, parameters and calculations.
  • Topic 5: PHARMACOKINETICS II
  • Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Topic 6: PHARMACODYNAMICS
  • MULTIPLE-CHOICE TEST 1(Topics 1-5).
  • Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Topic 7: FACTORS AFFECTING DRUG EFFECTS
  • Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Beer's list, STOPP-START, FORTA, PLLR. Pharmacogenetics.
  • Topic 8: PHARMACOVIGILANCE, ADVERSE DRUG REACTIONS
  • PRESCRIPTION TEST
  • Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety.
  • Topic 9: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Classification, basic pharmacological characteristics of drug effects on receptors of the sympathetic (alpha, beta) and parasympathetic (nicotinic, muscarinic) nervous systems. Pharmacodynamics, both direct and indirect mechanisms of action, second messenger systems. Drugs affecting sympathetic nervous system.
  • Topic 10: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM, SPASMOLYTIC DRUGS, MUSCLE RELAXANTS
  • Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs, muscle relaxants.
  • Topic 11: ANAESTHETIC DRUGS
  • MULTIPLE-CHOICE TEST 2 (Topics 6-10).
  • Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Topic 12: ANALGESICS, DRUGS USED IN GOUT
  • Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • Topic 13: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Topic 14: SEX HORMONES
  • Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs. Uterotonics and tocolytics.
  • Topic 15: GLUCOCORTICOIDS, THYROID HORMONES
  • MULTIPLE-CHOICE TEST 3 (Topics 11-14).
  • Basic pharmacological characteristics of glucocorticoids and thyroid hormones.
Literature
    required literature
  • Ritter J et al. Rang and Dale's pharmacology. 9th Edition. Edinburgh : Elsevier [2020]
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů :: Portál Lékařské fakulty Masarykovy
    recommended literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • Základy receptury léčivých přípravků. Nováková a kol., 2010, http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • Základy speciální receptury léčivých přípravků, Juřica a kol., 2013, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • Životní cyklus léčiv, Demlová a kol., 2014, http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
  • Základy farmakoekonomiky, Říhová a kol, 2016, http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
    not specified
  • Markova farmakoterapie vnitřních nemocí. Edited by Josef Marek - Michal Vrablík. 5., zcela přepracované a d. Praha: Grada, 2019, xxiv, 868. ISBN 9788024750781. info
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Farmakologie pro studenty bakalářských oborů na LF MU, Máchalová a kol., 2015, http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
  • Výzkum nových léčiv od zrodu k registraci, Starobová a kol., 2006, http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html
  • Farmakovigilance a propagace léčiv, Vršková a kol., 2007 http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
Teaching methods
practicals, class discussion
Practicals in pharmacology thematically follow the lectures, which take place regularly one week in advance. The organization of practicals assume basic knowledge of the material covered in the lecture. This knowledge is further deepened and practised on specific tasks and case studies. In the interactive syllabus of each exercise, there are materials for self-study and preparation for the practicals and a short ROPOT, which must be prepared before each lesson.
Assessment methods
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test. MCQ tests can be repeated once per semester. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of individually-made and a read-made preparations. For the individually-made preparation the Pharmacopoeial name of the main active substance, its single-therapeutic dose and the drug dosage form will be given. For the ready-made preparation the drug dosage form and the number of original packages to be prescribed will be listed. Database of registered RMP will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark of the subject.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2021, recent)
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