aZLPF0521p Pathophysiology I - lecture

Faculty of Medicine
autumn 2022
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
doc. RNDr. Sabina Ševčíková, Ph.D. (lecturer)
MUDr. Jan Máchal, Ph.D. (lecturer)
Mgr. Katarína Chalásová, Ph.D. (assistant)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 14:00–15:40 B22/116 aula
Prerequisites (in Czech)
aZLFY0422p Physiology II - lecture && ( aZLBC041c Biochemistry II - pract. || aZLBC0422c Biochemistry II - pract. ) && ( aZLBC041s Biochemistry II sem || aZLBC0422s Biochemistry II sem )&& ( aZLAN0222s Anatomy II - sem. || aZLAN0333s Anatomy III - seminar ) && ( aZLAN0222c Anatomy II - dissection || aZLAN0333c Anatomy III-dissect. ) && aZLHE0322c Histology and Embryol.II -prac && aZLLT0222s Bas.Med.Terminology II -sem.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Pathophysiology is a subject focusing on causes (aetiology) and mechanisms of disease development (pathogenesis) incl. changes inflicted by diseases on the level of the whole organism. Disease is usually (with exception of sudden events) a long terms process hidden (asymptomatic) for some time and only later and under certain circumstances might become clinically apparent illness. We aim to help the students to understand WHY and HOW are the changes unfolded. We also aspire to facilitate understanding disease etiopathogenesis complexly, i.e. from initial molecular and/or genetic alterations, via cellular, tissue and organ or event. systemic process. Pathophysiology represents an integrating discipline in medical curriculum bridging the theoretical/preclinical and clinical phase. Inextricably, despite the predominantly theoretical nature of the subject, we want to contribute to the building of the „evidence based medicine“ paradigm accompanied by the appreciation of the „precision medicine“ concept.
Learning outcomes
General pathophysiology
Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student demonstrates understanding of an influence of external factors on disease development, especially in oral cavity
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances, especially those of Ca++, Mg++ and K+
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing, especially in oral cavity
Student explains an importance of micronutrients abnormalities, especially considering oral cavity state
Student knows results of abnormal vitamin levels, especially in oral cavity
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes
Syllabus
  • Detailed syllabus is provided in IS - Study materials - instructions
Literature
    recommended literature
  • Pathophysiology of disease : an introduction to clinical medicine. Edited by Gary D. Hammer - Stephen J. McPhee. Eight edition. New York: McGraw-Hill Education, 2018, xiv, 814. ISBN 9781260288513. info
  • KUMAR, Vinay, Abul K. ABBAS and Jon C. ASTER. Robbins & Cotran pathologic basis of disease. Illustrated by James A. Perkins. Ninth edition. Philadelphia: Elsevier Saunders, 2015, xvi, 1391. ISBN 9780808924500. info
Teaching methods
Lecture.
Assessment methods
Pathophysiology course is finalised by an oral exam. Student will select questions from 4 different topics and he/she is given time to prepare answers (up to 120 min). Following topics will be represented by 1 question in oral exam: • A: circulatory, respiratory systems and kidney pathophysiology • B: gastrointestinal, endocrine, hematopoietic, musculoskeletal and nervous system pathophysiology • C: general pathophysiology • Study materials include practical tutorials, recommended literature and handouts provided for lectures.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
Information on the extent and intensity of the course: 30.
Teacher's information
http://www.med.muni.cz/patfyz
Lectures are scheduled at UCB Auditorium B22/116, Tuesdays 14-15.40
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2022, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2022/aZLPF0521p