aZLBC0321s Biochemistry I - seminar

Faculty of Medicine
autumn 2023
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
RNDr. Hana Paulová, CSc. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: MUDr. Michaela Králíková, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Wed 16:00–17:40 A16/215
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to practice basic metabolic processes and pathways occurring at the cellular level.
Understanding these processes is the basis for understanding metabolism at the tissue and organ level, which is studied in the follow-up course Biochemistry II.
Learning outcomes
In the end of the course students will able to:
  • understand the properties and function of enzymes.
  • describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism.
  • understand the principles of energy production, utilization and deposition at the cellular level.
  • explain the function of cell membranes, the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
  • describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
  • understand the relationship between protein structure and function.
  • explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
  • discuss the principles of some diseases at the molecular level.
    • Syllabus
    • Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell).
    • Membrane structure and assembly. Transport across membranes.
    • Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types.
    • Enzymes - reaction rate, progress curve, the Michaelis plot and Michaelis constant, enzyme inhibition.
    • Coenzymes, their relationship to vitamins.
    • The citric acid cycle. The respiratory chain and oxidative phosphorylation.
    • Digestion of saccharides. Metabolism of glucose - glycolysis, gluconeogenesis. Glycogenesis and glycogenolysis.
    • Digestion of proteins. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance.
    • Important reactions in amino acid catabolism. li>Digestion of lipids. Biosynthesis and desaturation of fatty acids. Ketogenesis. Synthesis of triacylglycerols.
    • Desaturation of fatty acids. Metabolism of phospholipids. Metabolism of cholesterol and bile acids.
    • Replication, transcription.
    Literature
      required literature
    • Interactive Syllabus of the course in IS MUNI.
    • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
      recommended literature
    • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013, ix, 495. ISBN 9783131003737. info
    • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
    • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017, xiii, 289. ISBN 9789352701148. info
    Teaching methods
    Active work in seminars, problem solving, discussions.
    Assessment methods
    Credit. Conditions for giving the course-unit credit:
    1) completion of all seminars and 2) completion of in-term tests.
    Failure to meet the requirements of in-term tests requires a resit test, which may be repeated only once. All absences must be made up before a resit test.
    Detailed conditions are published in Study materials posted under the course/Interactive Syllabus.
    Language of instruction
    English
    Further comments (probably available only in Czech)
    The course is taught annually.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    The course is also listed under the following terms autumn 2020, autumn 2021, autumn 2022, autumn 2024.
    • Enrolment Statistics (autumn 2023, recent)
    • Permalink: https://is.muni.cz/course/med/autumn2023/aZLBC0321s