aVLBE05 Essentials of Human Biochemistry

Faculty of Medicine
autumn 2024
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Iva Audy (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Wed 16:00–17:40 A16/213
Prerequisites (in Czech)
aVLBC0321p Biochemistry I - lecture || aZLBC0321p Biochemisty I - lecture
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 44 student(s).
Current registration and enrolment status: enrolled: 24/44, only registered: 0/44
fields of study / plans the course is directly associated with
Course objectives
The aim is to understand the basic biochemical processes characteristic at the cell level and individual tissues and organs and the principles of their regulation.
Learning outcomes
Upon completion of the course, the student will be able to:
- Demonstrate an understanding of bioenergetics and biological oxidation, including redox reactions and their role in cellular energy production.
- Apply knowledge of enzyme kinetics and factors influencing enzyme activity to analyze and interpret biochemical pathways.
- Describe principles of the regulation of gene expression and its significance in cellular function and disease.
- Understand the basic metabolism of carbohydrates and the implications of carbohydrate-related disorders like diabetes mellitus and explain the regulation of blood glucose levels.
- Comprehend the metabolism of lipids and the relevance of lipid-related disorders such as hyperlipidemia.
- Understand cholesterol metabolism, its role in cellular processes, and the synthesis of cholesterol and steroids.
- Understand amino acid metabolism, including the urea cycle, and recognize disorders related to amino acid metabolism.
- Comprehend the metabolism of nitrogen-containing compounds, such as nucleotides and heme, and understand purine and pyrimidine metabolism, disorders related to nitrogen metabolism.
- Understand the integration of carbohydrate, lipid, and protein metabolism in various physiological states.
- Understand the regulation of water balance, electrolyte concentrations, and acid-base balance, as well as the mechanisms involved in maintaining homeostasis.
- Describe cell signalling pathways and signal transduction mechanisms, including the role of receptors, second messengers, and intracellular signalling cascades in physiological processes and diseases.
- Explain the process of blood clotting and the functions of the extracellular matrix, including collagen synthesis and bone metabolism.
Syllabus
  • Bioenergetics and biological oxidation. Enzyme kinetics
  • Nucleic acid metabolism, gene expression and regulation
  • Carbohydrate metabolism and glucose homeostasis
  • Lipid metabolism
  • Cholesterol and steroids
  • Protein and amino acid metabolism
  • Nitrogen-containing compounds
  • Integration of body fuel metabolism in various states
  • Water, electrolyte, and acid-base homeostasis
  • Signal transduction pathways, control of cell metabolism
  • Hemostasis. Extracellular matrix
  • ROPOT
Literature
    required literature
  • Seminar texts and lecture handouts from the courses Biochemistry I and II
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY and P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
Teaching methods
Problem-based learning of biochemistry, reflecting basic knowledge from previous courses of Biochemistry I and II.
The essential biochemical topics will be presented (lecture-like mode), followed by immediate discussions (seminar-like mode). Students will be encouraged to see biochemical processes and relations in a broader perspective.
Assessment methods
Credit. Conditions for giving the course-unit credit: attendance, four absences will be tolerated. ROPOT is not a prerequisite for credit.
Language of instruction
English
Further comments (probably available only in Czech)
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms autumn 2023.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2024/aVLBE05