ZLBC041s Biochemistry II - seminar

Faculty of Medicine
spring 2019
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
Ing. Martina Čarnecká, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (seminar tutor)
MUDr. Miroslava Hlaváčová, Ph.D. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
doc. Mgr. Ondřej Peš, Ph.D. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
PharmDr. Kristýna Šebrlová, Ph.D. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
Lenka Nerudová (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
ZLBC041s/21: Fri 12:00–13:40 A16/213, J. Slanina
ZLBC041s/22: Fri 12:00–13:40 A16/215, H. Paulová
ZLBC041s/23: Fri 12:00–13:40 A16/213, J. Slanina
ZLBC041s/24: Fri 12:00–13:40 A16/215, H. Paulová
Prerequisites (in Czech)
ZLLC011p Medical Chemistry - lecture && ZLBF011p Med.Physics and Informat.-lect && ZLBI0222p Biology II-lect. && ZLBC0221s Biochemistry I - seminar && ZLFY0321c Physiology I - pract. && ZLFY0321s Physiology I - sem.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry lecture (ZLBC041p). The knowledge of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome)are thoroughly practiced during Biochemistry seminars.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Laboratory tests in clinical biochemistry. Sources of error, assessing the significance of a test result. Enzyme assays in clinical diagnostics. Plasma lipoproteins, interconversion of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion. Blood glucose (sources, comsumption, regulation). Diabetes mellitus. 1st written test (Sources of error of biochemical tests, assessing the significance of results. Digestion, absorption and transport of lipids, lipoproteins, cholesterol, metabolism of lipids at the tissue and organ level, metabolism of steroid hormones, metabolism of glucose in the absorptive, postabsorptive state, and in prolonged fasting (the liver, adipose tissue, and muscle), diabetes and impairments of saccharide metabolism). Catabolism of proteins and of amino acid nitrogen. Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of fixed ammonia, the glutamine cycle. Nitrogenous compounds excreted into the urine. Protein intake and nitrogen balance. Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, postabsorptive state, and prolonged starvation. The liver functions – the role in metabolism of nutrients, hormones, and vitamins. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinaemia. Biotransformation of xenobiotics. 2nd written test (Proteins in nutrition, nitrogen metabolism, integration of intermediary metabolism of nutrients, biochemical functions of the liver, catabolism of haemoglobin, metabolism of xenobiotics). Neurotransmitter and hormone receptors. Water and mineral metabolism. Electrolyte composition of blood plasma, buffer bases. Respiration – transport of oxygen and CO2. The role of the kidney and the liver in acid-base balance. Blood acid-base parameters, the values indicating particular type of disturbance. 3rd written test (Immunochemical techniques, neurotransmitter and hormone receptors, water and mineral metabolism, iontograms, acid-base balance.) Major functions of the kidney. Glomerular filtration. Tubular resorption and secretion. Urine - normal constituents, amounts of nitrogenous compounds excreted per 24 h. The proteinuria types. Urinary sediment, renal stones. Biochemistry of Ca, P, F. Composition of bones and teeth, saliva.
Literature
    required literature
  • Podklady pro semináře jsou k dispozici v IS, studijní materiály předmětu ZLBC041s. Seminar files are available in IS, study materials of ZLBC041s.
Teaching methods
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Assessment methods
Conditions for giving the course-unit credit: Three short tests are written during the semester. Students that will obtain 52/75 points or more during the semester are not obliged to write the credit test. The other students will write the credit test with the 30 questions in the last week of the semester. The limit for passing the credit test is 14 points. Students that will not fulfill this limit will be allowed to repeat the test once. Remedial dates for writing the credit test will be scheduled in IS. Students that will not fulfill this requirement will not be given the course-unit credit. Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to the examination of Biochemistry II
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2020.
  • Enrolment Statistics (spring 2019, recent)
  • Permalink: https://is.muni.cz/course/med/spring2019/ZLBC041s